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Lung Cancer

  • Branislav Jeremić
  • Francesc Casas
  • Sherif Abdel-Wahab
  • Nikola Cihoric
  • Pavol Dubinsky
  • Ana Mena Merino
  • Luhua Wang
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

In spite of recent advances in both biology and technology of diagnosis and treatment of lung cancer, the overall results remain dismal. After initial treatment, irrespective of stage and histology of the disease, local/regional recurrence is a frequent type of failure. While it is virtually unknown which proportion of patients initially treated with chest radiotherapy undergo reirradiation during the natural course of the disease, there are more reports documenting outcome of reirradiation in recent years. The majority of available studies are retrospective in nature and of limited size. External beam radiation therapy has been used to treat local/regional intrathoracic recurrences after previous radiation therapy for lung cancer, mostly non-small cell histology. In most cases, the aim of the treatment was palliation of symptoms. However, the increasing availability of new technology such as intensity-modulated and stereotactic radiotherapy has resulted in promising outcome after these more aggressive regimens. While endobronchial brachytherapy remains useful in palliating symptomatic recurrences, it is used less frequently in recent years. Although no guideline exists, likely due to considerable variety in first-line radiation therapy parameters, different planning and retreatment characteristics, and lack of validated prognostic factors, current wisdom calls for setting up objectives upfront and making prudent use of available technology.

Keywords

Small Cell Lung Cancer Median Survival Time External Beam Radiation Therapy Bronchial Stump Biologically Equivalent Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Agolli L, Valeriani M, Carnevale A, Falco T, Bracci S, De Sanctis V, Minniti G, Enrici RM, Osti MF (2015) Role of salvage stereotactic body radiation therapy in post-surgical loco-regional recurrence in a selected population of non-small cell lung cancer patients. Anticancer Res 35:1783–1789PubMedGoogle Scholar
  2. Beavis AW, Abdel-Hamid A, Upadhyay S (2005) Re-treatment of a lung tumour using a simple intensity-modulated radiotherapy approach. Br J Radiol 78:358–361CrossRefPubMedGoogle Scholar
  3. Bedwinek J, Petty A, Bruton C, Sofield J, Lee L (1991) The use of high dose rate endobronchial brachytherapy to palliate symptomatic endobronchial recurrence of previously irradiated bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 22:23–30CrossRefGoogle Scholar
  4. Berman AT, Ciunci, CA, Lin H, Both S, Langer CJ, Varillo K, Rengan R, Hahn SM, Fagundes MD, Hartsell W (2013) Multi-institutional prospective study of reirradiation with proton beam radiotherapy for non-small cell lung cancer. J Clin Oncol 31(suppl; abstr 7578)Google Scholar
  5. Binkley MS, Hiniker SM, Chaudhuri A, Maxim PG, Diehn M, Loo BW Jr, Shultz DB (2015) Dosimetric factors and toxicity in highly conformal thoracic reirradiation. Int J Radiat Oncol Biol Phys. pii: S0360-3016(15)26844-7. doi: 10.1016/j.ijrobp.2015.12.007
  6. Cetingoz R, Arikan-Alicikus Z, Nur-Demiral A, Durmak-Isman B, Bakis-Altas B, Kinay M (2009) Is re-irradiation effective in symptomatic local recurrence of non small cell lung cancer patients? A single institution experience and review of the literature. J BUON 14:33–40PubMedGoogle Scholar
  7. Chang JY, Balter PA, Dong L, Yang Q, Liao Z, Jeter M, Bucci MK, McAleer MF, Mehran RJ, Roth JA, Komaki R (2008) Stereotactic body radiation therapy in centrally and superiorly located stage I or isolated recurrent non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 72:967–971CrossRefPubMedPubMedCentralGoogle Scholar
  8. Coon D, Gokhale AS, Burton SA, Heron DE, Ozhasoglu C, Christie N (2008) Fractionated stereotactic body radiation therapy in the treatment of primary, recurrent, and metastatic lung tumors: The role of Positron Emission Tomography/Computed Tomography-based treatment planning. Clin Lung Cancer 9:217–221CrossRefPubMedGoogle Scholar
  9. Curran WJ Jr, Herbert SH, Stafford PM, Sandler HM, Rosenthal SA, McKenna WG, Hughes E, Dougherty MJ, Keller S (1992) Should patients with post-resection locoregional recurrence of lung cancer receive aggressive therapy? Int J Radiat Oncol Biol Phys 24:25–30CrossRefPubMedGoogle Scholar
  10. Delaney G, Barton M, Jacob S, Jalaludin B (2003) A model for decision making for the use of radiotherapy in lung cancer. Lancet Oncol 4:120–128CrossRefPubMedGoogle Scholar
  11. Delclos ME, Komaki R, Morice RC, Allen PK, Davis M, Garden A (1996) Endobronchial brachytherapy with high-dose-rate remote afterloading for recurrent endobronchial lesions. Radiology 201:279–282CrossRefPubMedGoogle Scholar
  12. Drodge CS, Ghosh S, Fairchild A (2014) Thoracic reirradiation for lung cancer: a literature review and practical guide. Ann Palliat Med 3:75–91Google Scholar
  13. Ebara T, Tanio N, Etoh T, Shichi I, Honda A, Nakajima N (2007) Palliative reirradiation for in-field recurrence after definitive radiotherapy in patients with primarylung cancer. Anticancer Res 27(1):531–534Google Scholar
  14. Emami B, Graham MV, Deedy M, Shapiro S, Kucik N (1997) Radiation therapy for intrathoracic recurrence of non-small cell lung cancer. Am J Clin Oncol (CCT) 20:46–50CrossRefGoogle Scholar
  15. Estall V, Barton MB, Vinod SK (2007) Patterns of radiotherapy re-treatment in patients with lung cancer: a retrospective, longitudinal study. J Thorac Oncol 2:531–536CrossRefPubMedGoogle Scholar
  16. Faria SL, Menard S, Devic S, Sirois C, Souhami L, Lisbona R, Freeman CR (2008) Impact of FDG-PET/CT on radiotherapy volume delineation in non-small-cell lung cancer and correlation of imaging stage with pathologic findings. Int J Radiat Oncol Biol Phys 70:1035–1038CrossRefPubMedGoogle Scholar
  17. Gauwitz M, Ellerbroek N, Komaki R, Putnam JB Jr, Ryan MB, DeCaro L, Davis M, Cundiff J (1992) High dose endobronchial irradiation in recurrent bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 23:397–400CrossRefPubMedGoogle Scholar
  18. Green N, Kern W (1978) The clinical course and treatment results of patients with postresection locally recurrent lung cancer. Cancer 42:2478–2482CrossRefPubMedGoogle Scholar
  19. Green N, Melbye RW (1982) Lung cancer: Retreatment of local recurrence after definitive irradiation. Cancer 49:865–868CrossRefPubMedGoogle Scholar
  20. Gressen EL, Werner-Wasik M, Cohn J, Topham A, Curran WJ Jr (2000) Thoracic reirradiation for symptomatic relief after prior radiotherapeutic management for lung cancer. Am J Clin Oncol (CCT) 23:160–163CrossRefGoogle Scholar
  21. Grgic A, Nestle U, Schaefer-Schuler A, Kremp S, Ballek E, Fleckenstein J, Rübe C, Kirsch CM, Hellwig D (2009) Nonrigid versus rigid registration of thoracic 18F-FDG PET and CT in patients with lung cancer: an intraindividual comparison of different breathing maneuvers. J Nucl Med 50:1921–1926CrossRefPubMedGoogle Scholar
  22. Gustafson G, Vicini F, Freedman L, Johnston E, Edmudson G, Sherman S, Pursel S, Komic M, Chen P, Borrego JC, Seidman J, Martinez A (1995) High dose rate endobronchial brachytherapy in the management of primary and recurrent bronchogenic malignancies. Cancer 75:2345–2350CrossRefPubMedGoogle Scholar
  23. Hanna GG, McAleese J, Carson KJ, Stewart DP, Cosgrove VP, Eakin RL, Zatari A, Lynch T, Jarritt PH, Young VA, O’Sullivan JM, Hounsell AR (2010) (18)F-FDG PET-CT simulation for non-small-cell lung cancer: effect in patients already staged by PET-CT. Int J Radiat Oncol Biol Phys 77:24–30CrossRefPubMedGoogle Scholar
  24. Hatlevoll R, Karlsen KO, Skovlund E (1999) Endobronchial radiotherapy for malignant bronchial obstruction or recurrence. Acta Oncol 38:999–1004CrossRefPubMedGoogle Scholar
  25. Hauswald H, Stoiber E, Rochet N, Lindel K, Grehn C, Becker HD, Debus J, Harms W (2010) Treatment of recurrent bronchial carcinoma: the role of high-dose-rate endoluminal brachytherapy. Int J Radiat Oncol Biol Phys 77:373–377CrossRefPubMedGoogle Scholar
  26. Hayakawa K, Mitsuhashi N, Saito Y, Nakayama Y, Furuta M, Sakurai H, Kawashima M, Ohno T, Nasu S, Niibe H (1999) Limited field irradiation for medically inoperable patients with peripheral stage I non-small cell lung cancer. Lung Cancer 26:137–142CrossRefPubMedGoogle Scholar
  27. Hung JJ, Hsu WH, Hsieh CC, Huang BS, Huang MH, Liu JS, Wu YC (2009) Post-recurrence survival in completely resected stage I non-small cell lung cancer with local recurrence. Thorax 64:192–196CrossRefPubMedGoogle Scholar
  28. Ihde DC, Bilek FS, Cohen MH (1979) Response to thoracic radiotherapy in patients with small cell carcinoma of the lung after failure of combination chemotherapy. Radiology 132:443–446CrossRefPubMedGoogle Scholar
  29. International Agency for Research on Cancer (IARC): http://globocan.iarc.fr (2012)
  30. Jackson MA, Ball DL (1987) Palliative retreatment of locally recurrent lung cancer after radical radiotherapy. Med J Aust 147:391–394PubMedGoogle Scholar
  31. Jeremic B, Bamberg M (2002) External beam radiation therapy for bronchial stump recurrence of non-small-cell lung cancer after complete resection. Radiother Oncol 64:251–257CrossRefPubMedGoogle Scholar
  32. Jeremic B, Shibamoto Y, Acimovic LJ, Milisavljevic S (1997) Hyperfractionated radiotherapy alone for clinical stage I nonsmall cell lung cancer. Int J Radiat Oncol Biol Phys 38:521–525CrossRefPubMedGoogle Scholar
  33. Jeremic B, Shibamoto Y, Acimovic LJ, Milisavljevic S (1999a) Hyperfractionated radiotherapy for clinical Stage II nonsmall cell lung cancer. Radiother Oncol 51:141–145CrossRefPubMedGoogle Scholar
  34. Jeremic B, Shibamoto Y, Milicic B, Milisavljevic S, Nikolic N, Dagovic A, Aleksandrovic J, Radosavljevic-Asic G (1999b) External beam radiation therapy alone for loco-regional recurrence of non-small-cell lung cancer after complete resection. Lung Cancer 23:135–142CrossRefPubMedGoogle Scholar
  35. Jeremic B, Shibamoto Y, Acimovic L, Nikolic N, Dagovic A, Aleksandrovic J, Radosavljevic-Asic G (2001) Second cancers occurring in patients with early stage non-small cell lung cancer treated with chest radiation therapy alone. J Clin Oncol 19:1056–1063CrossRefPubMedGoogle Scholar
  36. Kagami Y, Nishio M, Narimatsu N, Mjoujin M, Sakurai T, Hareyama M, Saito A (1998) Radiotherapy for locoregional recurrent tumours after resection of non-small cell lung cancer. Lung Cancer 20:31–35CrossRefPubMedGoogle Scholar
  37. Kawaguchi T, Matsumura A, Iuchi K, Ishikawa S, Maeda H, Fukai S, Komatsu H, Kawahara M (2006) Second primary cancers in patients with stage III non-small cell lung cancer successfully treated with chemo-radiotherapy. Jpn J Clin Oncol 36:7–11CrossRefPubMedGoogle Scholar
  38. Kelly JF, Delclos ME, Morice RC, Huaringa A, Allen PK, Komaki R (2000) High-dose-rate endobrobchial brachytherapy effectively palliates symptoms due to airway tumors: the 10-year M.D. Anderson Cancer Center experience. Int J Radiat Oncol Biol Phys 48:697–702CrossRefPubMedGoogle Scholar
  39. Kelly P, Balter PA, Rebueno N, Sharp HJ, Liao Z, Komaki R, Chang JY (2010) Stereotactic body radiation therapy for patients with lung cancer previously treated with thoracic radiation. Int J Radiat Oncol Biol Phys 78:1387–1393Google Scholar
  40. Kelsey CR, Clough RW, Marks LB (2006) Local recurrence following initial resection of NSCLC: salvage is possible with radiation therapy. Cancer J 12:283–288CrossRefPubMedGoogle Scholar
  41. Kilburn JM, Kuremsky JG, Blackstock AW, Munley MT, Kearns WT, Hinson WH, Lovato JF, Miller AA, Petty WJ, Urbanic JJ (2014) Thoracic re-irradiation using stereotactic body radiotherapy (SBRT) techniques as first or second course of treatment. Radiother Oncol 110:505–510Google Scholar
  42. Kono K, Murakami M, Sasaki R (1998) Radiation therapy for non-small cell lung cancer with postoperative intrathoracic recurrence. Nippon Igaku Hoshasen Gakkai Zasshi 58:18–24PubMedGoogle Scholar
  43. Kopelson G, Choi NCH (1980) Radiation therapy for postoperative local-regionally recurrent lung cancer. Int J Radiat Oncol Biol Phys 6:1503–1506CrossRefPubMedGoogle Scholar
  44. Kramer GWPM, Gans S, Ullmann E, van Meerbeck JP, Legrand C, Leer JWH (2004) Hypofractionated external beam radiotherapy as retreatment for symptomatic non-small-cell lung carcinoma: an effective treatment? Int J Radiat Oncol Biol Phys 58:1388–1393CrossRefPubMedGoogle Scholar
  45. Kruser TJ, McCabe BP, Mehta MP, Khuntia D, Campbell TC, Geye HM, Cannon GM (2014) Reirradiation for locoregionally recurrent lung cancer: outcomes in small cell and non-small cell lung carcinoma. Am J Clin Oncol 37:70–76Google Scholar
  46. Law MR, Henk JM, Lennox SC, Hodson M (1982) Value of radiotherapy for tumour on the bronchial stump after resection of bronchial carcinoma. Thorax 37:496–499CrossRefPubMedPubMedCentralGoogle Scholar
  47. Leung J, Ball D, Worotniuk T, Laidlaw C (1995) Survival following radiotherapy for post-surgical locoregional recurrence of non-small cell lung cancer. Lung Cancer 13:121–127CrossRefPubMedGoogle Scholar
  48. Liu H, Zhang X, Vinogradskiy YY, Swisher SG, Komaki R, Chang JY (2012) Predicting radiation pneumonitis after stereotactic ablative radiation therapy in patients previously treated with conventional thoracic radiation therapy. Int J Radiat Oncol Biol Phys 84:1017–1023Google Scholar
  49. MacManus M, Nestle U, Rosenzweig KE, Carrio I, Messa C, Belohlavek O, Danna M, Inoue T, Deniaud-Alexandre E, Schipani S, Watanabe N, Dondi M, Jeremic B (2009) Use of PET and PET/CT for radiation therapy planning: IAEA expert report 2006-2007. Radiother Oncol 91:85–94CrossRefPubMedGoogle Scholar
  50. Martini N, Melamed MR (1975) Multiple primary lung cancers. J Thorac Cardiovasc Surg 70:606–612PubMedGoogle Scholar
  51. McAvoy SA, Ciura KT, Rineer JM, Allen PK, Liao Z, Chang JY, Palmer MB, Cox JD, Komaki R, Gomez DR (2013) Feasibility of proton beam therapy for reirradiation of locoregionally recurrent non-small cell lung cancer. Radiother Oncol 109:38–44CrossRefPubMedGoogle Scholar
  52. Mehta MP, Shahabi S, Jarjour NN, Kinsella TJ (1989) Endobronchial irradiation for malignant airway obstruction. Int J Radiat Oncol Biol Phys 17:847–851CrossRefPubMedGoogle Scholar
  53. Mendiondo OA, Dillon M, Beach LJ (1983) Endobronchial brachytherapy in the treatment of recurrent bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 9:579–582CrossRefPubMedGoogle Scholar
  54. Meijneke TR, Petit SF, Wentzler D, Hoogeman M, Nuyttens JJ (2013) Reirradiation and stereotactic radiotherapy for tumors in the lung: dose summation and toxicity. Radiother Oncol 107:423–427Google Scholar
  55. Micke O, Prott FJ, Schäfer U, Wagner W, Pötter R (1995) Endoluminal HDR brachytherapy in the palliative treatment of patients with the recurrence of a non-small-cell bronchial carcinoma after prior radiotherapy. Strahlenther Onkol 171:554–559PubMedGoogle Scholar
  56. Montebello JF, Aron BS, Manatunga AK, Horvath JL, Peyton FW (1993) The reirradiation of recurrent bronchogenic carcinoma with external beam irradiation. Am J Clin Oncol 16:482–488CrossRefPubMedGoogle Scholar
  57. Morita K, Fuwa N, Suzuki Y, Nishio M, Sakai K, Tamaki Y, Niibe H, Chujo M, Wada S, Sugawara T, Kita M (1997) Radical radiotherapy for medically inoperable non-small cell lung cancer in clinical stage I: retrospective analysis of 149 patients. Radiother Oncol 42:31–36CrossRefPubMedGoogle Scholar
  58. Mountain CF (1986) A new international staging system for lung cancer. Chest 89:225S–233SCrossRefPubMedGoogle Scholar
  59. Naruke T, Goya T, Tsuchiya R, Suemasu K (1988) Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thorac Cardiovasc Surg 96:440–447PubMedGoogle Scholar
  60. Nestle U, Walter K, Schmidt S, Licht N, Nieder C, Motaref B, Hellwig D, Niewald M, Ukena D, Kirsch CM, Sybrecht GW, Schnabel K (1999) 18F-deoxyglucose positron emission tomography (FDG-PET) for the planning of radiotherapy in lung cancer: high impact in patients with atelectasis. Int J Radiat Oncol Biol Phys 44:593–597CrossRefPubMedGoogle Scholar
  61. Nestle U, Kremp S, Grosu AL (2006) Practical integration of [18F]-FDG-PET and PET-CT in the planning of radiotherapy for non-small cell lung cancer (NSCLC): the technical basis, ICRU-target volumes, problems, perspectives. Radiother Oncol 81:209–225CrossRefPubMedGoogle Scholar
  62. Ochs JJ, Tester WJ, Cohen MH, Lichter AS, Ihde DC (1983) Salvage radiation therapy for intrathoracic small cell carcinoma of the lung progressing on combination chemotherapy. Cancer Treat Rep 67:1123–1126PubMedGoogle Scholar
  63. Ohguri T, Imada H, Yahara K, Moon SD, Yamaguchi S, Yatera K, Mukae H, Hanagiri T, Tanaka F, Korogi Y (2012) Re-irradiation plus regional hyperthermia for recurrent non- small cell lung cancer: a potential modality for inducing long-term survival in selected patients. Lung Cancer 77:140–145Google Scholar
  64. Okamoto Y, Murakami M, Yoden E, Sasaki R, Okuno Y, Nakajima T, Kuroda Y (2002) Reirradiation for locally recurrent lung cancer previously treated with radiation therapy. Int J Radiat Oncol Biol Phys 52:390–396CrossRefPubMedGoogle Scholar
  65. Ono R, Egawa S, Suemasu K, Sakura M, Kitagawa T (1991) Radiotherapy in inoperable stage I lung cancer. Jpn J Clin Oncol 21:125–128CrossRefPubMedGoogle Scholar
  66. Ornadel D, Duchesne G, Wall P, Ng A, Hetzel M (1997) Defining the roles of high dose rate endobronchial brachytherapy and laser resection for recurrent bronchial malignancy. Lung Cancer 16:203–213CrossRefPubMedGoogle Scholar
  67. Patel NR, Lanciano R, Sura K, Yang J, Lamond J, Feng J, Good M, Gracely EJ, Komarnicky L, Brady L (2015) Stereotactic body radiotherapy for re-irradiation of lung cancer recurrence with lower biological effective doses. J Radiat Oncol 4:65–70Google Scholar
  68. Poltinnikov IM, Fallon K, Xiao Y, Reiff JE, Curran WJ Jr, Werner-Wasik M (2005) Combination of longitudinal and circumferential three-dimensional esophageal dose distribution predicts acute esophagitis in hypofractionated reirradiation of patients with non-small-cell lung cancer treated in stereotactic body frame. Int J Radiat Oncol Biol Phys 62:652–658CrossRefPubMedGoogle Scholar
  69. Riegel AC, Bucci MK, Mawlawi OR, Johnson V, Ahmad M, Sun X, Luo D, Chandler AG, Pan T (2010) Target definition of moving lung tumors in positron emission tomography: correlation of optimal activity concentration thresholds with object size, motion extent, and source-to-background ratio. Med Phys 37:1742–1752CrossRefPubMedPubMedCentralGoogle Scholar
  70. Salazar OM, Yee GJ, Slawson RG (1991) Radiation therapy for chest recurrence following induction chemotherapy in small cell lung cancer. Int J Radiat Oncol Biol Phys 21:645–650CrossRefPubMedGoogle Scholar
  71. Schaefer A, Kremp S, Hellwig D, Rübe C, Kirsch CM, Nestle U (2008) A contrast-oriented algorithm for FDG-PET-based delineation of tumour volumes for the radiotherapy of lung cancer: derivation from phantom measurements and validation in patient data. Eur J Nucl Med Mol Imaging 35:1989–1999CrossRefPubMedGoogle Scholar
  72. Seagren SL, Harrell JH, Horn RA (1985) High dose rate intraluminal irradiation in recurrent endobronchial carcinoma. Chest 88:810–814CrossRefPubMedGoogle Scholar
  73. Seung SK, Matthew SM (2011) Salvage SBRT for previously irradiated lung cancer. J Cancer Ther 2:190–195Google Scholar
  74. Shaw EG, Brindle JS, Creagan ET, Foote RL, Trastek VF, Buskirk SJ (1992) Locally recurrent non-small-cell lung cancer after complete surgical resection. Mayo Clin Proc 67:1129–1133CrossRefPubMedGoogle Scholar
  75. Sibley GS, Jamieson TA, Marks LB, Anscher MS, Prosnitz LR (1998) Radiotherapy alone for medically inoperable stage I non-small-cell lung cancer: The Duke experience. Int J Radiat Oncol Biol Phys 40:149–154CrossRefPubMedGoogle Scholar
  76. Siegel R, Ma J, Zou Z, Jemal A (2009) Cancer Statistics, 2014. CA Cancer J Clin 64:9–29CrossRefGoogle Scholar
  77. Sugimura H, Nichols FC, Yang P, Allen MS, Cassivi SD, Deschamps C, Williams BA, Pairolero PC (2007) Survival after recurrent nonsmall-cell lung cancer after complete pulmonary resection. Ann Thorac Surg 83:409–417CrossRefPubMedGoogle Scholar
  78. Sutedja G, Baris G, Schaake-Koning C, van Zandwijk N (1992) High dose rate brachytherapy in patients with local recurrences after radiotherapy of non-small cell lung cancer. Int J Radiat Oncol Biol Phys 24:551–553CrossRefPubMedGoogle Scholar
  79. Tada T, Fukuda H, Matsui K, Hirashima T, Hosono M, Takada Y, Inoue Y (2005) Non-small-cell lung cancer: reirradiation for loco-regional relapse previously treated with radiation therapy. Int J Clin Oncol 10:247–250CrossRefPubMedGoogle Scholar
  80. Tetar S, Dahele M, Griffioen G, Slotman B, Senan S (2015) High-dose conventional thoracic re-irradiation for lung cancer: updated results. Lung Cancer 88:235–236Google Scholar
  81. Trakul N, Harris JP, Le QT, Hara WY, Maxim PG, Loo BW Jr, Diehn M (2012) Stereotactic ablative radiotherapy for reirradiation of locally recurrent lung tumors. J Thorac Oncol 7:1462–1465Google Scholar
  82. Trovo M, Minatel E, Durofil E, Polesel J, Avanzo M, Baresic T, Bearz A, Del Conte A, Franchin G, Gobitti C, Rumeileh IA, Trovo MG (2014) Stereotactic body radiation therapy for re-irradiation of persistent or recurrent non-small cell lung cancer. Int J Radiat Oncol Biol Phys 88:1114–1119Google Scholar
  83. Vanuytsel LJ, Vansteenkiste JF, Stroobants SG, De Leyn PR, De Wever W, Verbeken EK, Gatti GG, Huyskens DP, Kutcher GJ (2000) The impact of (18)F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) lymph node staging on the radiation treatment volumes in patients with non-small cell lung cancer. Radiother Oncol 55:317–324CrossRefPubMedGoogle Scholar
  84. Valakh V, Miyamoto C, Micaily B, Chan P, Neicu T, Li S (2013) Repeat stereotactic body radiation therapy for patients with pulmonary malignancies who had previously received SBRT to the same or an adjacent tumor site. J Cancer Res Ther 9:680–685Google Scholar
  85. Videtic GM, Rice TW, Murthy S, Suh JH, Saxton JP, Adelstein DJ, Mekhail TM (2008) Utility of positron emission tomography compared with mediastinoscopy for delineating involved lymph nodes in stage III lung cancer: insights for radiotherapy planning from a surgical cohort. Int J Radiat Oncol Biol Phys 72:702–706CrossRefPubMedGoogle Scholar
  86. Wu KL, Jiang G-L, Qian H, Wang L-J, Yang H-J, Fu X-L, Zhao S (2003) Three-dimensional conformal radiotherapy for locoregionally recurrent lung carcinoma after external beam irradiation: a prospective phase I-II clinical trial. Int J Radiat Oncol Biol Phys 57:1345–1350CrossRefPubMedGoogle Scholar
  87. Wu K, Ung YC, Hornby J, Freeman M, Hwang D, Tsao MS, Dahele M, Darling G, Maziak DE, Tirona R, Mah K, Wong CS (2010) PET CT thresholds for radiotherapy target definition in non-small-cell lung cancer: how close are we to the pathologic findings? Int J Radiat Oncol Biol Phys 77:699–706CrossRefPubMedGoogle Scholar
  88. Yano T, Hara N, Ichinose Y, Asoh H, Yokoyama H, Ohta M, Hata K (1994) Local recurrence after complete resection for nonsmall-cell carcinoma of the lung. Significance of local control by radiation treatment. J Thorac Cardiovasc Surg 10:8–12Google Scholar
  89. Yoshitake T, Shioyama Y, Nakamura K, Sasaki T, Ohga S, Shinoto M, Terashima K, Asai K, Matsumoto K, Hirata H, Honda H (2013) Definitive fractionated re-irradiation for local recurrence following stereotactic body radiotherapy for primary lung cancer. Anticancer Res 33:5649–5653Google Scholar
  90. Zorlu AF, Selek U, Emri S, Gurkayanak M, Akyol FH (2008) Second line palliative endobronchial radiotherapy with HDR Ir 192 in recurrent lung carcinoma. Yonsei Med J 49:620–624CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Branislav Jeremić
    • 1
    • 2
  • Francesc Casas
    • 3
  • Sherif Abdel-Wahab
    • 4
  • Nikola Cihoric
    • 5
  • Pavol Dubinsky
    • 6
  • Ana Mena Merino
    • 7
  • Luhua Wang
    • 8
  1. 1.Department of Radiation OncologyInstitute of Pulmonary DiseasesSremska KamenicaSerbia
  2. 2.BioIRC Centre for Biomedical ResearchKragujevacSerbia
  3. 3.Department of Radiation OncologyUniversity ClinicBarcelonaSpain
  4. 4.Department of Clinical OncologyAin Shams UniversityCairoEgypt
  5. 5.Department of Radiation OncologyInselspitalBernSwitzerland
  6. 6.Department of Radiation OncologyEastern Slovakia UniversityKosiceSlovakia
  7. 7.Department of Radiation OncologyUniversity of Palma de MajorcaPalmaSpain
  8. 8.Department of Radiation OncologyChinese Medical Academy of ScienceBeijingChina

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