Normal Tissue Tolerance to Reirradiation

  • Carsten Nieder
  • Johannes A. Langendijk
Part of the Medical Radiology book series (MEDRAD)


As a result of longer survival times, even among patients with incurable malignancies, the prevalence of patients at risk of developing second primary tumours and/or locoregional recurrences in previously irradiated areas might increase. Consequently, the need for additional therapeutic measures providing local control and/or symptom palliation along different lines of treatment has emerged. This has resulted in increasing requests for delivering a second and sometimes even third course of radiation to target volumes within or close to previously irradiated anatomical areas. On the one hand, improved imaging and delivery techniques including image-guided and intensity-modulated radiotherapy might facilitate reirradiation of previously exposed regions of the body. On the other hand, late toxicity is of concern because it often causes serious impact on health-related quality of life. Therefore, knowledge about long-term recovery of occult radiation injury is of utmost importance. This chapter summarises available experimental and clinical data on the effects of reirradiation to various organs.


Late Toxicity Radiation Therapy Oncology Group Radiation Pneumonitis Biologically Effective Dose Priming Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Oncology and Palliative MedicineNordland HospitalBodøNorway
  2. 2.Department of Radiation OncologyUniversity Medical Center Groningen/University of GroningenGroningenThe Netherlands

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