Therapy-Induced Changes in Head and Neck

Part of the Medical Radiology book series (MEDRAD)


Radiation with or without concomitant chemotherapy of the head and neck region is associated with acute and chronic toxicity and adverse effects on organ function. Therapy-induced dysphagia is a complex multifactorial disorder, constituting one of the most common and prominent problems affecting quality of life of the patients. Classical fluoroscopy is still the method of choice to search for morphologic (fistula, stricture, resection defect) and functional (impaired sensory or motor function of the pharyngoesophageal tube and larynx, xerostomia) deficits. Bone injury is another severe, although relatively rare, condition induced by radiation and specific drugs, especially bisphosphonates. While fatty replacement of the bone marrow within the radiation field is a deterministic effect without clinical significance for the patient, radiation-induced inflammation, fibrosis, disorganization of extracellular matrix, and tissue remodeling may lead to devitalized bone with mucosal ulceration, pathologic fracture, and fistula formation. Similar effects have been associated with osteoclast-inhibiting therapies, including bisphosphonates and denosumab.


Apparent Diffusion Coefficient Lower Esophageal Sphincter Pharyngeal Transit Time Free Flap Reconstruction Suprahyoid Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Apparent diffusion coefficient


American Society for Bone and Mineral Research




Cone beam computed tomography


Contrast material




Dysphagia-aspiration-related structures


Diffusion-weighted imaging


Fiber-optic endoscopic evaluation of swallowing


Modified barium swallow


Nasopharyngeal cancer


Osteonecrosis of the jaw


Oropharyngeal swallow efficiency


Oral residue




Oral transit time


Pharyngeal constrictors


Pharyngeal residue


Pharyngeal transit time




Radiation Therapy Oncology Group


Radiation therapy


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of RadiologyUniversity ErlangenErlangenGermany

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