Thoracic Manifestations of Systemic Diseases

  • David V. Holland
  • R. Paul Guillerman
  • Alan S. Brody
Part of the Medical Radiology book series (MEDRAD)


A wide variety of systemic diseases have manifestations in the pediatric chest. Among these systemic diseases are connective tissue diseases, granulomatous diseases, immunodeficiency disorders, vasculitis, sickle cell disease, cystic fibrosis, ciliary dyskinesia, histiocytosis, phakomatoses, and storage disorders. The primary manifestations are diverse, and may include interstitial lung disease, air space disease, pleuritis, lymphadenopathy, and skeletal abnormalities. Secondary effects, such as bronchiectasis from recurrent infection, are also common. Although the underlying systemic disease has often been previously diagnosed, it is not uncommon for pulmonary manifestations to be the first signs of a systemic disease, and knowledge of the pertinent clinical and imaging features may allow the radiologist to be the first to suggest an underlying systemic disease.


Systemic Lupus Erythematosus Cystic Fibrosis Juvenile Idiopathic Arthritis Chronic Granulomatous Disease Langerhan Cell Histiocytosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • David V. Holland
    • 1
  • R. Paul Guillerman
    • 2
  • Alan S. Brody
    • 3
  1. 1.Mallinckrodt Institute of RadiologyWashington University School of MedicineSt. LouisUSA
  2. 2.Department of Pediatric RadiologyTexas Children’s Hospital, Baylor College of MedicineHoustonUSA
  3. 3.Department of RadiologyChildren’s Hospital Medical CenterCincinnatiUSA

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