Target Volume Definition in Postoperative Radiotherapy

  • Martin Stuschke
Part of the Medical Radiology book series (MEDRAD)


Randomized trials on postoperative radiotherapy for prostate were reviewed. Target volume consensus guidelines were compared and discussed with respect to inter-observer variability, normal tissue exposure and size of the target volume.


Target Volume Postoperative Radiotherapy Clinical Target Volume Salvage Radiotherapy Biochemical Relapse 
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  1. Bolla M, van Poppel H, Tombal B et al (2012) Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomized controlled trial (EORTC trial 22911). Lancet 380:2018–2027PubMedCrossRefGoogle Scholar
  2. Croke J, Malone S, Roustan-Delatour N et al (2012) Postoperative radiotherapy in prostate cancer: the case of the missing target. Int J Radiat Oncol Biol Phys 83:1160–1168PubMedCrossRefGoogle Scholar
  3. Davis JB, Reiner B, Dusserre A et al (2002) Quality assurance of the EORTC trial 2291. A phase III study of post-operative external radiotherapy in pathological stage T3N0 prostatic carcinoma: the dummy run. Radiother Oncol 64:65–73PubMedCrossRefGoogle Scholar
  4. Ishiyama H, The BS, Blanco AI et al (2013) Salvage intensity modulated radiotherapy using endorectal balloon after radical prostatectomy: clinical outcomes. Int J Urol 20:1178–1183PubMedCrossRefGoogle Scholar
  5. King CR (2012) The timing of salvage radiotherapy after radical prostatectomy: a systematic review. Int J Radiat Oncol Biol Phys 84:104–111PubMedCrossRefGoogle Scholar
  6. Koontz BF, Das S, Temple K et al (2009) Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy. Med Dosim 34:256–260PubMedCrossRefGoogle Scholar
  7. Malone S, Croke J, Roustan-Delatour N et al (2012) Postoperative radiotherapy for prostate cancer: a comparison of four consensus guidelines and dosimetric evaluation of 3D-CRT versus tomotherapy IMRT. Int J Radiat Oncol Biol Phys 84:725–732PubMedCrossRefGoogle Scholar
  8. Michalski JM, Lawton C, El Naqa I et al (2010a) Development of RTOG consensus guidelines for the definition of the clinical target volume for postoperative conformal radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys 76:361–368PubMedCentralPubMedCrossRefGoogle Scholar
  9. Michalski JM, Gay H, Jackson A et al (2010b) Radiation dose-volume effects in radiation-induced rectal injury. Int J Radiat Oncol Biol Phys 76(Suppl. 3):S123–S129PubMedCentralPubMedCrossRefGoogle Scholar
  10. Mitchell DM, Perry L, Smith S et al (2009) Assessing the effect of a contouring protocol on postprostatectomy radiotherapy clinical target volumes and interphysician variation. Int J Radiat Oncol Biol Phys 75:990–993PubMedCrossRefGoogle Scholar
  11. Ost P, De Meerleer G, Vercauteren T et al (2011) Delineation of the postprostatectomy prostate bed using computed tomography: interobserver variability following the EORTC delineation guidelines. Int J Radiat Oncol Biol Phys 81:e143–e149PubMedCrossRefGoogle Scholar
  12. Postmanns P, Bossi A, Vandeputte K et al (2007) Guidelines for target volume definition in post-operative radiotherapy for prostate cancer, on behalf of the EORTC radiation oncology group. Radiother Oncol 84:121–127CrossRefGoogle Scholar
  13. Sidhom MA, Kneebone AB, Lehman M et al (2008) Post-prostatectomy radiation therapy: consensus guidelines of the Australian and NW Zealand radiation oncology genito-urinary group. Radiother Oncol 88:10–19PubMedCrossRefGoogle Scholar
  14. Swanson GP, Hussey MA, Tangen CM et al (2007) Predominant treatment failure in prostatectomy patients is local: analysis of patterns of treatment failure in SWOG 8794. J Clin Oncol 25:2225–2229PubMedCrossRefGoogle Scholar
  15. Stephenson AJ, Scardino PT, Kattan MW et al (2007) Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy. J Clin Oncol 25:2035–2041PubMedCentralPubMedCrossRefGoogle Scholar
  16. Thompson IM, Tangen CM, Paradelo J et al (2009) Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term follow up of a randomized clinical trial. J Urol 181:956–962PubMedCentralPubMedCrossRefGoogle Scholar
  17. Thompson IM, Tangen CM, Paradelo J et al (2006) Adjuvant radiotherapy for pathologically advanced prostate cancer. JAMA 296(19):2329–2335Google Scholar
  18. Wiltshire KL, Brock KK, Haider MA et al (2007) Anatomic boundaries of the clinical target volume (prostate bed) after radical prostatectomy. Int J Radiat Oncol Biol Phys 69:1090–1999PubMedCrossRefGoogle Scholar
  19. Wiegel T, Bottke D, Steiner U et al (2009) Phase III postoperative adjuvant radiotherapy after radical prostatectomy alone in pT3 prostate cancer with postoperative undetectable prostate-specific antigen: ARO 96-02/AUO AP 09/95. J Clin Oncol 27:2924–2930PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Direktor der Klinik und Poliklinik für StrahlentherapieUniversitätsklinikum EssenEssenGermany

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