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Genetic Basis of Normal Tissue Radiosensitivity and Late Toxicity in Breast Cancer

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Book cover Breast Cancer Biology for the Radiation Oncologist

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Individual variations in sensitivity to radiation toxicity are clinically important, but their genetic basis is poorly understood. Single nucleotide polymorphisms (SNPs) in many genes have been correlated to a higher risk of acute or late radiation toxicity. This chapter discusses cellular studies predictive of radiation sensitivity and studies of specific genes of interest, with a focus on breast cancer research. Radiogenomics studies of ATM, XRCC1, and TGFB1 are discussed, and other genes and SNPs associated with radiation toxicity are summarized. Recent results of the RAPPER study indicate that the candidate gene approach is inadequate to discover clinically useful indicators of radiation sensitivity. Genome-wide association studies (GWAS) and international collaborations may hold the key to future progress in this area.

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  1. St. Charles Cancer Treatment Center, Bend, OR, USA

    Dhara MacDermed

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  1. Dhara MacDermed
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Correspondence to Dhara MacDermed .

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  1. Department of Radiation Oncology, Northwestern University, Chicago, Illinois, USA

    Jonathan Strauss

  2. Division of Radiation Oncology, Stritch School of Medicine, Cardinal Bernardin Cancer Center, Chicago, Illinois, USA

    William Small

  3. Dept. Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

    Gayle E. Woloschak

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MacDermed, D. (2014). Genetic Basis of Normal Tissue Radiosensitivity and Late Toxicity in Breast Cancer. In: Strauss, J., Small, W., Woloschak, G. (eds) Breast Cancer Biology for the Radiation Oncologist. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2014_1045

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