Biological Subtypes of Breast Cancer
Breast cancer is no longer thought of as a single disease, but rather as collection of subtypes characterized by molecular signatures. The use of gene array analysis has provided insights into the dominant driver pathways that effect individual tumors and translate into clinical manifestations of the disease, response to treatment and overall clinical outcome.
KeywordsBreast Cancer Molecular Subtype HER2 Receptor Adjuvant Trastuzumab Luminal Subtype
- van’t Veer LJ, Dai H et al (2002) Gene expression profiling predicts clinical outcome of breast cancer. Nature 415(6871):530–6Google Scholar