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Late Toxicity and Quality of Life

  • Michael Geier
  • Hans Geinitz
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

As there seems to be no perceptible impact of treatment choice on overall survival of patients with localized prostate cancer, other criteria have to be taken into consideration choosing the appropriate treatment option for the individual patient. There is increasing awareness that predicted functional outcomes, including quality of life, alongside objective measures of late adverse genitourinary and gastrointestinal toxicity are essential components of the decision-making process in the management of patients with prostate cancer. Assessing the impact of available treatment modalities on health-related quality of life (HRQOL) therefore is gaining further importance. This chapter gives an overview of the main toxicity scoring instruments and HRQOL measures. It furthermore summarizes pathophysiological mechanisms of the mainly reported late toxicities after radiotherapy and gives a short overview of their possible treatment options. Due to the large amount of studies on side effects and HRQOL in prostate cancer patients it is beyond the scope of this chapter to give a comprehensive review on this issue. Instead, general aspects as well as particular problems and obstacles regarding the assessment and interpretation of HRQOL-Data will be highlighted.

Keywords

Fecal Incontinence Late Toxicity Radiation Therapy Oncology Group Dose Volume Histogram Global HRQOL 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Radiation OncologyKrankenhaus der Barmherzigen Schwestern LinzLinzAustria

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