Oropharyngeal Carcinoma

  • Jeremy Setton
  • Ian Poon
  • Nadeem Riaz
  • Eli Scher
  • Nancy Lee
Part of the Medical Radiology book series (MEDRAD)


The oropharynx is contiguous with the oral cavity anteriorly, the larynx and hypopharynx inferiorly, and the nasopharynx superiorly. It is commonly divided into four subsites: the tonsillar region, base of the tongue, soft palate, and pharyngeal wall


Soft Palate Posterior Pharyngeal Wall Retropharyngeal Lymph Node Target Volume Delineation Pharyngeal Constrictor Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Ang KK, Harris J, Wheeler R et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363:24–35CrossRefPubMedPubMedCentralGoogle Scholar
  2. Beitler JJ, Zhang Q, Fu KK et al (2014) Final results of local-regional control and late toxicity of RTOG 9003: a randomized trial of altered fractionation radiation for locally advanced head and neck cancer. Int J Radiat Oncol Biol Phys 89:13–20CrossRefPubMedPubMedCentralGoogle Scholar
  3. Bussels B, Hermans R, Reijnders A et al (2006) Retropharyngeal nodes in squamous cell carcinoma of oropharynx: incidence, localization, and implications for target volume. Int J Radiat Oncol Biol Phys 65:733–738CrossRefPubMedGoogle Scholar
  4. Eisbruch A, Harris J, Garden AS et al (2010) Multi-institutional trial of accelerated hypofractionated intensity-modulated radiation therapy for early-stage oropharyngeal cancer (RTOG 00–22). Int J Radiat Oncol Biol Phys 76:1333–1338CrossRefPubMedGoogle Scholar
  5. Garden AS, Dong L, Morrison WH et al (2013) Patterns of disease recurrence following treatment of oropharyngeal cancer with intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys 85:941–947CrossRefPubMedGoogle Scholar
  6. Romesser PB, Qureshi MM, Shah BA et al (2012) Superior prognostic utility of gross and metabolic tumor volume compared to standardized uptake value using PET/CT in head and neck squamous cell carcinoma patients treated with intensity-modulated radiotherapy. Ann Nucl Med 26:527–534CrossRefPubMedPubMedCentralGoogle Scholar
  7. Sanguineti G, Califano J, Stafford E et al (2009) Defining the risk of involvement for each neck nodal level in patients with early T-stage node-positive oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 74:1356–1364CrossRefPubMedGoogle Scholar
  8. Setton J, Caria N, Romanyshyn J et al (2012) Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: an update of the Memorial Sloan-Kettering Cancer Center experience. Int J Radiat Oncol Biol Phys 82:291–298CrossRefPubMedGoogle Scholar
  9. Syed R, Bomanji JB, Nagabhushan N et al (2005) Impact of combined (18)F-FDG PET/CT in head and neck tumours. Br J Cancer 92:1046–1050CrossRefPubMedPubMedCentralGoogle Scholar
  10. Tam M, Riaz N, Schupak K et al (2013) Sparing Bilateral Ib and Contralateral High Level II Nodes in Node-Positive (n+) Oropharyngeal Carcinoma (OPC) Improves Quality of Life on a Prospective Self-Reported Xerostomia Questionnaire. Int J Radiat Oncol Biol Phys 87:S437–S438Google Scholar
  11. Vandecaveye V, De Keyzer F, Verslype C et al (2009) Diffusion-weighted MRI provides additional value to conventional dynamic contrast-enhanced MRI for detection of hepatocellular carcinoma. Eur Radiol 19:2456–2466CrossRefPubMedGoogle Scholar

Further Reading

  1. Adelstein DJ, Ridge JA, Brizel DM et al (2012) Transoral resection of pharyngeal cancer: summary of a National Cancer Institute Head and Neck Cancer Steering Committee Clinical Trials Planning Meeting, November 6–7, 2011, Arlington, Virginia. Head Neck 34:1681–1703CrossRefPubMedGoogle Scholar
  2. Denis F, Garaud P, Bardet E et al (2004) Final results of the 94–01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol 22:69–76CrossRefPubMedGoogle Scholar
  3. Eisbruch A, Kim HM, Feng FY et al (2011) Chemo-IMRT of oropharyngeal cancer aiming to reduce dysphagia: swallowing organs late complication probabilities and dosimetric correlates. Int J Radiat Oncol Biol Phys 81:e93–e99CrossRefPubMedPubMedCentralGoogle Scholar
  4. O’Sullivan B, Warde P, Grice B et al (2001) The benefits and pitfalls of ipsilateral radiotherapy in carcinoma of the tonsillar region. Int J Radiat Oncol Biol Phys 51:332–343CrossRefPubMedGoogle Scholar
  5. O’Sullivan B, Huang SH, Siu LL et al (2013) Deintensification candidate subgroups in human papillomavirus related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol 31:543–550CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Jeremy Setton
    • 1
  • Ian Poon
    • 2
  • Nadeem Riaz
    • 1
  • Eli Scher
    • 1
  • Nancy Lee
    • 1
  1. 1.Department of Radiation OncologyMemorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.Department of Radiation OncologyUniversity of Toronto/Sunnybrook Health Sciences CentreTorontoCanada

Personalised recommendations