Advanced Imaging Modalities and Treatment of Gliomas: Radiation Therapy
This chapter deals with radiation therapy techniques used for treatment of malignant glioma. It shows how they have become more and more sophisticated over the past decades. Due to this achievement in the planning procedure an exact definition of the target volume has become indispensable and increased the role of imaging in radiotherapy. The pros and cons of various imaging modalities are discussed from the view of a radiation oncologist.
KeywordsPositron Emission Tomography Planning Target Volume Clinical Target Volume Radiation Therapy Oncology Group Whole Brain Radiation Therapy
- Chang CH, Horton J, Schoenfeld D et al (1983) Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A Joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. Cancer 52(6):997–1007PubMedCrossRefGoogle Scholar
- Combs SE, Kieser M, Rieken S et al (2010) Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: the CLEOPATRA trial. BMC Cancer 10:478PubMedCrossRefPubMedCentralGoogle Scholar
- Selker RG, Shapiro WR, Burger P et al (2002) The Brain Tumor Cooperative Group NIH Trial 87–01: a randomized comparison of surgery, external radiotherapy, and carmustine versus surgery, interstitial radiotherapy boost, external radiation therapy, and carmustine. Neurosurgery 51(2):343–355PubMedGoogle Scholar
- Souhami L, Seiferheld W, Brachman D et al (2004) Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93–05 protocol. Int J Radiat Oncol Biol Phys 60(3):853–860PubMedCrossRefGoogle Scholar