Squamous Cell Carcinoma of Unknown Primary in the Head and Neck
Squamous cell carcinoma of unknown primary (SQCUP) in the head and neck is defined by malignancy in the cervical lymph nodes without identification of the primary tumor after extensive workup. Potential sites of the occult primary tumor include the nasopharynx, oropharynx, larynx, and hypopharynx (Fig. 1). The most common primary sites that are eventually identified upon workup for patients with SQCUP are the tonsils and base of the tongue (~90 %) (2009). The distribution of lymph node metastases from a SQCUP of the head and neck is shown in Fig. 2. The most common sites of involvement are levels II and III.
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