Dynamic MR Imaging of the Skeletal Musculature: From Static Measures to a Dynamic Assessment of the Muscular (Loco-) Motion

  • Shantanu Sinha
  • Usha Sinha
Part of the Medical Radiology book series (MEDRAD)


The muscle–tendon is a complex structure and involves the complex interplay of passive and active elements, fiber architecture that ultimately determines the force transmission and muscle mechanics. The ability to noninvasively image the muscle–tendon complex during contractions provides an unprecedented tool to study the normal physiology and its changes under different conditions (e.g., in normal aging, sarcopenia, limb disuse and muscle atrophy, and muscle diseases such as dystrophy). We describe the development of sophisticated MR imaging sequences that can directly map muscle motion (velocity), or muscle tissue displacement. A brief overview of imaging sequences, post processing is provided as a background to the technology. The derivation of 1D, 2D and 3D strain, and strain rate maps is outlined underlying the ability to extract the complete 3D strain tensor from appropriate MR datasets. The MR-compatible device to enable different muscle motion is described in detail; this piece is critical for the successful implementation of functional muscle dynamics using MRI. Velocity and strain distributions in the normal lower leg muscles, in the forearm are presented. These studies highlight the heterogeneous strain distributions and the link to connective tissue distribution in the muscles as well as to the geometry of the fibers (fiber length, pennation angle, and curvature differences along the length the muscle aponeurosis). These studies have also identified inter- and intra-fascicular heterogeneities in strain and in novel indices such as the architectural gear ratio. Tendon dynamics can also be mapped using the velocity-encoded data and force-dependent length changes, stiffness, and the transition point from linear to nonlinear behavior of the force-length (F-L) curve in human Achilles tendon are discussed. The applications of these elegant MR techniques to altered muscle conditions are presented; however the number of studies is limited. The application of MR dynamic muscle imaging with the velocity encoded-phase contrast imaging to subjects with Achilles tendon rupture and chronic unloading under controlled conditions are presented. In both applications, the utility of the technique in identifying muscle functional and structural changes indicate that this is a valuable tool awaiting widespread clinical implementation. This chapter concludes with technical developments in this area of MR imaging where 2D and 3D strain tensor mappings are outlined. These developments offer exciting possibilities to explore muscle structure and functional relationships. Coupled with diffusion tensor imaging to extract muscle fiber architecture, dynamic 3D muscle imaging will enable the detailed understanding of muscle physiology in normal and altered conditions.


Achilles Tendon Isometric Contraction Medial Gastrocnemius Strain Rate Tensor Pennation Angle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of RadiologyUniversity of CaliforniaSan DiegoUSA
  2. 2.Department of PhysicsSan Diego State UniversitySan DiegoUSA

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