Acute Adverse Reactions to Contrast Media: Mechanisms and Prevention

  • Olivier Clement
  • Judith A. W. Webb
Part of the Medical Radiology book series (MEDRAD)


Acute adverse reactions are defined as reactions occurring within the hour following contrast medium injection. They may occur after any of the contrast agents used for radiography, ultrasound, or magnetic resonance imaging. The majority of reactions are mild, and some of the mild symptoms reported are not even caused by the contrast agent. However, severe and life threatening reactions may still occur. Hypersensitivity reactions after contrast medium may be allergic or non-allergic. The factors predisposing to acute reactions and the methods to reduce the incidence of acute reactions to both iodine- and gadolinium-based reactions are discussed in this chapter. The use of premedication is controversial, as the limited scientific basis for its use is now recognized. Even after premedication, adverse reactions may still occur.


Contrast Medium Ionic Agent Contrast Medium Injection Acute Reaction Weber Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Service de RadiologieHôpital Européen Georges PompidouParisFrance
  2. 2.Consultant Emeritus, Diagnostic Radiology DepartmentSt. Bartholomew’s Hospital, University of LondonLondonUK

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