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Skeletal Muscle MR Imaging Beyond Protons: With a Focus on Sodium MRI in Musculoskeletal Applications

  • Armin M. Nagel
  • Marc-André Weber
  • Arijitt Borthakur
  • Ravinder Reddy
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

Proton MRI is the mainstay of muscle MR imaging, however with the advent of dedicated coil and sequence technology, also non-proton MRI is now possible using high-field MRI units. This chapter includes a discussion of the principles and challenges of non-proton muscle imaging with focus on the use of sodium MRI. Dedicated sequences and the benefit of higher field strength will be discussed and clinical applications within the musculoskeletal system, such as sodium MRI in muscular diseases and cartilage/joint abnormalities will be reviewed. Moreover, other nuclei that are prone to MR imaging, such as chlorine, potassium, and oxygen will also be addressed.

Keywords

Oxygen Consumption Rate Chemical Exchange Saturation Transfer Inversion Recovery Imaging Hypokalemic Periodic Paralysis Duchenne Muscle Dystrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Especially the implementation of X-nuclei MR imaging profits much from an interdisciplinary team working on this subject together. Thus we thank several physicists, radiologists, physiologists, orthopedic surgeons and neurologists with whom we worked for several years together on X-nuclei MRI. Explicitly, we would thank the following collaborators: Reiner Umathum, Manuela B. Roesler, Stefan H. Hoffmann, and Wolfhard Semmler, all Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg/Germany; Frank Lehmann-Horn and Karin Jurkat-Rott, Neurophysiology, Ulm University, Ulm/Germany. Work on Sects. 14 and 6 was funded in part by the Helmholtz Alliance ICEMED - Imaging and Curing Environmental Metabolic Diseases, through the Initiative and Networking Fund of the Helmholtz Association. Moreover, we acknowledge that Sect. 5 was performed at a NIH-NIBIB supported Biomedical Technology Research Center (P41 EB015893).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Armin M. Nagel
    • 1
  • Marc-André Weber
    • 2
  • Arijitt Borthakur
    • 3
  • Ravinder Reddy
    • 3
  1. 1.Medical Physics in RadiologyGerman Cancer Research Center (DKFZ)HeidelbergGermany
  2. 2.Diagnostic and Interventional RadiologyUniversity Hospital HeidelbergHeidelbergGermany
  3. 3.Center for Magnetic Resonance and Optical Imaging, Department of RadiologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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