There is Evidence for the Superiority of Protons or Heavy Ions, Contra
Photon therapy is a safe and effective treatment for localised prostate cancer. It is used widely and has a strong evidence base. For three decades, proponents of proton and heavy ion therapy have claimed that these modalities have theoretical advantages which will translate into clinical benefit. However, there is no current evidence to support this. In this chapter we will assess the theoretical and clinical evidence for proton and heavy ion therapy and compare this with that for photon therapy. The health economic perspective will also be examined. We will show that there is no evidence for the superiority of protons or heavy ions over photon therapy.
KeywordsPlanning Target Volume Localise Prostate Cancer Stereotactic Body Radiotherapy Late Toxicity Relative Biological Effectiveness
- Jensen A.D, Munter, MW et al (2011). Review of clinical experience with ion beam radiotherapy. Br J Radiol 84 Spec No 1: S35–47Google Scholar
- Joiner M, Kogel Avd (2009). Basic clinical radiobiology. London, Hodder ArnoldGoogle Scholar
- Katz A (2012). Five-year biochemical control rates for stereotactic body radiotherapy for organ confined prostate cancer: a multi-institutional pooled analysis.Oral presentation at ASTRO annual meeting 2012Google Scholar
- Spratt DE, Pei X et al (2012). Long-term survival and toxicity in patients treated with high-dose intensity modulated radiation therapy for localized prostate cancer. Int J Radiat Oncol Biol PhysGoogle Scholar
- Zietman AL, Bae K et al (2010) Randomized trial comparing conventional-dose with high-dose conformal radiation therapy in early-stage adenocarcinoma of the prostate: long-term results from proton radiation oncology group/american college of radiology 95–09. J Clin Oncol 28(7):1106–1111PubMedCentralPubMedCrossRefGoogle Scholar