Skip to main content

Radioembolization: Identifying and Managing Anatomic Variants

  • Chapter
  • First Online:
Liver Radioembolization with 90Y Microspheres

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

Radioembolization treatment carries the risk of non-target embolization as well as of incomplete treatment. The distribution of microspheres reflects the arterial vascular territory subtended by the injected arteries. Thus, it is important to recognize anatomic variants in hepatic arterial anatomy. These variants include congenital accessory and replaced arteries supplying portions of the liver and the tumors within, as well as parasitized non-hepatic arteries recruited to supply arterial blood to intrahepatic tumors. Several different strategies allow more safe and complete radioembolization preparation and treatment in the presence of these variants. Consolidation or redistribution of flow may be performed to simplify or to increase the safety of microsphere administration. Likewise, parasitized extrahepatic vessels may be embolized to restore intrahepatic flow to tumors, thus, limiting risk for non-target embolization and increasing completeness of treatment. Both scenarios require close attention to tumor blood supply and recognition of arterial variants.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abdelmaksoud MHK, Louie JD, Kothary N et al (2011) Consolidation of hepatic arterial inflow by embolization of variant hepatic arteries in preparation for yttrium-90 radioembolization. J Vasc Interv Radiol 22(10):1364–1372

    PubMed  Google Scholar 

  • Abdelmaksoud MHK, Louie JD, Kothary N et al (2011) Embolization of parasitized extrahepatic arteries to reestablish intrahepatic arterial supply to tumors before yttrium-90 radioembolization. J Vasc Interv Radiol 22(10):1355–1362

    Article  PubMed  Google Scholar 

  • Andrews JC, Walker SC, Ackermann RJ, Cotton LA, Ensminger WD, Shapiro B (1994) Hepatic radioembolization with y-90 containing glass microspheres-preliminary-results and clinical follow-up. J Nucl Med 35(10):1637–1644

    CAS  PubMed  Google Scholar 

  • Bilbao JI, Garrastachu P, Herraiz MJ et al (2010) Safety and efficacy assessment of flow redistribution by occlusion of intrahepatic vessels prior to radioembolization in the treatment of liver tumors. Cardiovasc Interv Radiol 33(3):523–531

    Article  Google Scholar 

  • Charnsangavej C, Chuang VP, Wallace S, Soo CS, Bowers T (1982) Angiographic classification of hepatic arterial collaterals. Radiology 144(3):485–494

    CAS  PubMed  Google Scholar 

  • Chuang VP, Wallace S (1980) Hepatic arterial redistribution for intra-arterial infusion of hepatic neoplasms. Radiology 135(2):295–299

    CAS  PubMed  Google Scholar 

  • Chung JW, Park JH, Han JK, Choi BI, Kim TK, Han MC (1998) Transcatheter oily chemoembolization of the inferior phrenic artery in hepatocellular carcinoma: the safety and potential therapeutic role. J Vasc Interv Radiol 9(3):495–500

    Article  CAS  PubMed  Google Scholar 

  • Chung JW, Kim HC, Yoon JH et al (2006) Transcatheter arterial chemoembolization of hepatocellular carcinoma: prevalence and causative factors of extrahepatic collateral arteries in 479 patients. Korean J Radiol 7(4):257–266

    Article  PubMed Central  PubMed  Google Scholar 

  • Covey AM, Brody LA, Maluccio MA, Getrajdman GI, Brown KT (2002) Variant hepatic arterial anatomy revisited: digital subtraction angiography performed in 600 patients. Radiology 224(2):542–547

    Article  PubMed  Google Scholar 

  • Karunanithy N, Gordon F, Hodolic M et al (2011) Embolization of hepatic arterial branches to simplify hepatic blood flow before yttrium 90 radioembolization: a useful technique in the presence of challenging anatomy. Cardiovasc Interv Radiol 34(2):287–294

    Article  Google Scholar 

  • Kim HC, Chung JW, Lee W, Jae HJ, Park JH (2005) Recognizing extrahepatic collateral vessels that supply hepatocellular carcinoma to avoid complications of transcatheter arterial chemoembolization. Radiographics 25:S25–S40

    Article  PubMed  Google Scholar 

  • Kim HC, Chung JW, Choi SH, et al (2007) Hepatocellular carcinoma with internal mammary artery supply: feasibility and efficacy of transarterial chemoembolization and factors affecting patient prognosis. J Vasc Interv Radiol 18(5):611–619 (quiz 620)

    Google Scholar 

  • Koehler RE, Korobkin M, Lewis F (1975) Arteriographic demonstration of collateral arterial supply to liver after hepatic-artery ligation. Radiology 117(1):49–54

    CAS  PubMed  Google Scholar 

  • Lee KH, Liapi E, Vossen JA et al (2008) Distribution of iron oxide-containing embosphere particles after transcatheter arterial embolization in an animal model of liver cancer: evaluation with MR imaging and implication for therapy. J Vasc Interv Radiol 19(10):1490–1496

    Article  PubMed Central  PubMed  Google Scholar 

  • Lewandowski RJ, Sato KT, Atassi B et al (2007) Radioembolization with 90Y microspheres: angiographic and technical considerations. Cardiovasc Interv Radiol 30(4):571–592

    Article  Google Scholar 

  • Mays ET, Wheeler CS (1974) Demonstration of collateral arterial flow after interruption of hepatic arteries in man. N Engl J Med 290(18):993–996

    Article  CAS  PubMed  Google Scholar 

  • Michels NA (1966) Newer anatomy of liver and its variant blood supply and collateral circulation. Am J Surg 112(3):337–347

    Google Scholar 

  • Miyayama S, Matsui O, Akakura Y et al (2001) Hepatocellular carcinoma with blood supply from omental branches: treatment with transcatheter arterial embolization. J Vasc Interv Radiol 12(11):1285–1290

    Article  CAS  PubMed  Google Scholar 

  • Miyayama S, Yamashiro M, Okuda M et al (2010) The march of extrahepatic collaterals: analysis of blood supply to hepatocellular carcinoma located in the bare area of the liver after chemoembolization. Cardiovasc Interv Radiol 33(3):513–522

    Article  Google Scholar 

  • Park SI, Yun Lee D, Yoon Won J, Tae Lee J (2003) Extrahepatic collateral supply of hepatocellular carcinoma by the intercostal arteries. J Vasc Interv Radiol 14(4):461–468

    Article  PubMed  Google Scholar 

  • Riaz A, Lewandowski RJ, Kulik LM, et al (2009) Complications following radioembolization with yttrium-90 microspheres: a comprehensive literature review. J Vasc Interv Radiol 20(9):1121–1130 (quiz 1131)

    Google Scholar 

  • Seki H, Kimura M, Yoshimura N, Yamamoto S, Ozaki T, Sakai K (1998) Development of extrahepatic arterial blood supply to the liver during hepatic arterial infusion chemotherapy. Eur Radiol 8(9):1613–1618

    Article  CAS  PubMed  Google Scholar 

  • Tohma T, Cho A, Okazumi S et al (2005) Communicating arcade between the right and left hepatic arteries: evaluation with CT and angiography during temporary balloon occlusion of the right or left hepatic artery. Radiology 237(1):361–365

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rajesh P. Shah .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Shah, R.P., Sze, D.Y. (2013). Radioembolization: Identifying and Managing Anatomic Variants. In: Bilbao, J., Reiser, M. (eds) Liver Radioembolization with 90Y Microspheres. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2013_886

Download citation

  • DOI: https://doi.org/10.1007/174_2013_886

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-36472-3

  • Online ISBN: 978-3-642-36473-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics