Chronic Kidney Disease, Serum Creatinine and Estimated Glomerular Filtration Rate (eGFR)

Part of the Medical Radiology book series (MEDRAD)


Because of the nephrotoxicity of iodine-based contrast media and the more recently accepted role of gadolinium-based contrast media in the etiology of nephrogenic systemic fibrosis, the renal function of patients undergoing contrast enhanced imaging studies must be known so that, if necessary, appropriate preventive measures can be taken. The risk of these two adverse reactions increases with decreasing glomerular filtration rate, which cannot be measured directly. Measurement of serum creatinine with calculation of the glomerular filtration rate is used to identify at-risk patients. The possible methods for measuring renal function using laboratory tests and the various equations for estimating glomerular filtration rate are reviewed, and questionnaires to replace serum creatinine measurement in outpatients at low risk are discussed.


Chronic Kidney Disease Glomerular Filtration Rate Chronic Kidney Disease Stage Nephrogenic Systemic Fibrosis National Kidney Foundation 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Radiology and NuclearmedicineUniversity Hospital of BaselBaselSwitzerland
  2. 2.Department of Diagnostic RadiologyCopenhagen University Hospital HerlevHerlevDenmark

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