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A Critical Review of Meta-Analysis of Adverse Events After Contrast Media

  • Giuseppe Biondi-Zoccai
  • Giacomo Frati
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

Systematic reviews provide a point of view on a specific clinical topic by using explicit and structured methods for study search, selection, appraisal, and data extraction. When data pooling is performed using ad hoc statistical methods, a systematic review may also be described as a meta-analysis, although this type of analysis would more appropriately be described as a systematic review with meta-analysis. Adverse events after contrast agent administration are an ideal topic for systematic reviews, as they are uncommon. Any single randomized trial is unlikely to be adequately powered to accurately assess the incidence of adverse events and to compare adverse event rates between treatment groups while at the same time focusing on clinically relevant (i.e., hard) end-points. This chapter provides a concise but comprehensive overview of systematic reviews and meta-analyses, with particular focus on their application to adverse events after contrast agent administration.

Keywords

Systematic Review Contrast Agent Critical Limb Ischemia Contrast Agent Administration Beta Error 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Medico-Surgical Sciences and BiotechnologiesSapienza University of RomeLatinaItaly
  2. 2.Department of Medico-Surgical Sciences and BiotechnologiesSapienza University of RomeLatinaItaly

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