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MRI in Inflammatory Myopathies and Autoimmune-Mediated Myositis

  • Umesh A. Badrising
  • Hermien E. Kan
  • Jan JGM Verschuuren
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

In this chapter, dermatomyositis, polymyositis, inclusion body myositis, and the necrotizing myopathies are discussed in detail with regard to their clinical features, laboratory and histopathological findings, mimics and the imaging findings with magnetic resonance imaging, computed tomography, and ultrasound. With the focus on magnetic resonance imaging, its discriminating role between disorders during the diagnostic work-up, the evaluation of the extent and activity of the disease, and the gathering of information on fat replacement of muscles are considered. Furthermore, its use to locate the best site for a muscle biopsy to enhance the diagnostic yield of a histopathologically confirmed diagnosis and its use during the follow-up of patients in assessing the therapeutic effect of immunosuppressive and immunomodulating therapies and to detect signs of relapse are outlined.

Keywords

Muscle Biopsy Spinal Muscular Atrophy Fatty Infiltration Serum Creatine Kinase Inclusion Body Myositis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ATP

Adenosine triphosphate

CK

Creatine kinase

CT

Computed tomography

DM

Dermatomyositis

DWI

Diffusion weighted imaging

EMG

Electromyography

HIV

Human immunodeficiency virus

HLTV-I

Human T cell lymphotropic virus

HMGCR

3-hydroxy-3-methylglutaryl-coenzyme A reductase

IBM

Inclusion body myositis

IIM

Idiopathic inflammatory myopathies

JDM

Juvenile dermatomyositis

MAC

Membrane attack complex

MDA5

Melanoma differentiation matrix protein

MHC

Major histocompatibility complex

MRI

Magnetic resonance imaging

MRS

Magnetic resonance spectroscopy

MSA

Myositis specific antibody

MUAP

Muscle unit action potential

NM

Necrotizing myopathy

NXP-2

Nuclear matrix protein

PCr

Phosphocreatinine

PET

Positron emission tomography

Pi

Inorganic phosphate

PM

Polymyositis

SRP

Single recognition particle

STIR

Short tau inversion recovery

Notes

Acknowledgments

The authors would like to thank Janneke van de Vlekkert for her contribution.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Umesh A. Badrising
    • 1
  • Hermien E. Kan
    • 1
  • Jan JGM Verschuuren
    • 1
  1. 1.Department of Neurology, K5-QLeiden University Medical CentreLeidenThe Netherlands

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