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Radioembolization-Induced Liver Disease

  • Bruno Sangro
  • Mercedes Iñarrairaegui
  • Andrew S. Kennedy
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

The aim of liver radioembolization is to deliver an effective dose of radiation to liver tumors while the nontumoral liver is only exposed to much lower, nonharmful dose. However, irradiation of the nontumoral compartment of the liver may produce cell damage that can translate into changes in laboratory tests or clinical signs of liver dysfunction. Radioembolization-induced liver disease has been recently described as a syndrome consisting in jaundice and ascites that appears 1–2 months after treatment in the absence of tumor progression or bile duct occlusion. This complication is extremely rare in the absence of cirrhosis or intense prior exposure to chemotherapeutic agents particularly if chemotherapy is continued immediately after radioembolization. Its incidence is likely to be lower than 10 % and it has a transient or stable course in most cases, but it may unusually lead to overt liver failure. A conservative dose prescription and the use of low-dose steroids or ursodeoxycholic acid have been suggested as prophylactic measures.

Keywords

External Beam Radiation Therapy Liver Volume Ursodeoxycholic Acid Normal Tissue Complication Probability Glass Microsphere 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

CIBEREHD is funded by Instituto de Salud Carlos III.

The authors wish to thank Paloma Sangro for her valuable work in the review of the literature and the preparation of the manuscript.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Bruno Sangro
    • 1
    • 2
  • Mercedes Iñarrairaegui
    • 1
    • 2
  • Andrew S. Kennedy
    • 3
    • 4
  1. 1.Clinica Universidad de NavarraPamplonaSpain
  2. 2.Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD)PamplonaSpain
  3. 3.Radiation Oncology Research, Sarah Cannon Research InstituteTennesseeUSA
  4. 4.Department of Biomedical Engineering, Department of Mechanical and Aerospace EngineeringNorth Carolina State University RaleighRaleighUSA

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