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Complications and Side Effects

  • R. T. Hoffmann
  • Lourdes Diaz-Dorronsoro
  • José I. Bilbao
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

Radioembolization represents an effective tool for the treatment of primary and secondary liver tumors. Adequate use of this therapy requires knowledge and a multidisciplinary effort in order to obtain optimal results and avoid therapy-specific complications. A great deal of research has been undertaken in order to understand the angiographic, technical, and safety aspects concerning liver radioembolization. The most common complications of radioembolization include non-target radiation (pancreatitis, GI ulcers, cholecystitis), radiation pneumonitis, radiation-induced liver disease (radiation hepatitis), and biliary complications.

Keywords

Bile Duct Gall Bladder Bile Duct Injury Intrahepatic Bile Duct Cystic Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Ashizawa K, Matsunaga N, Aso N et al (1991) Bile lake: a complication of transcatheter hepatic arterial infusion and embolization therapy. Nipon Iagaku Hoshasen Gakkai Zasshi 51:121–126Google Scholar
  2. Carretero C, Munoz-Navas M, Betes M et al (2007) Gastroduodenal injury after radioembolization of hepatic tumors. Am J Gastroenterol 102:1–5CrossRefGoogle Scholar
  3. Covey AM, Brody LA, Maluccio MA, Getradjdman GJ, Brown KT (2002) Variant hepatic arterial anatomy revisited: digital substraction angiography performed in 600 patients. Radiology 224:542–547PubMedCrossRefGoogle Scholar
  4. De Luis E, Bilbao JI, Garcia-Jalon de Ciercoles JA et al (2008) In vivo evaluation of a new embolic spherical particle “Hepasphere” in a kidney animal model. Cardiovasc Intervent Radiol 31(2):367–376 PubMedCrossRefGoogle Scholar
  5. Kabayashi S, Nakamura Y, Terada T et al (1993) Postmortem survey of bile duct necrosis and biloma in hepatocellular carcinoma alter transcatheter arterial chemoembolization therapy: relevant to microvascular damages of peribiliary capillary plexus. Am J Gastroenterol 88:1410–1415Google Scholar
  6. Kim HK, Cheng YH, Song BC et al (2001) Ischemic bile duct injury as a serious complication after transarterial chemoembolization in patients with hepatocellular carcinoma. J Clin Gastroenterol 32:423–427PubMedCrossRefGoogle Scholar
  7. Kim HC, Cheng JW, Lee W, Jae HJ, Park JH (2005) Recognizing extrahepatic collateral vessels that supply hepatocellular carcinoma to avid complications of transcatheter arterial chemoembolization. Radiographics 25:S25–S39PubMedCrossRefGoogle Scholar
  8. Lau WY, Ho S, Leung TW et al (1998) Selective internal radiation therapy for nonresectable hepatocellular carcinoma with intraarterial infusion of 90yttrium microspheres. Int J Radiat Oncol Biol Phys 40:583–592PubMedCrossRefGoogle Scholar
  9. Leung WT, Lau WY, Ho SK et al (1994) Measuring lung shunting in hepatocellular carcinoma with intrahepatic-arterial technetium-99 m macroaggregated albumin. J Nucl Med 35:70–73PubMedGoogle Scholar
  10. Leung TW, Lau WY, Ho SK et al (1995) Radiation pneumonitis after selective internal radiation treatment with intraarterial 90yttrium-microspheres for inoperable hepatic tumors. Int J Radiat Oncol Biol Phys 33:919–924PubMedCrossRefGoogle Scholar
  11. Lewandosky RJ, Sato KT, Atassi B et al (2007) Radioembolization with 90Y microspheres: angiographic and technical considerations. Cadiovasc Intervent Radiol 30:571–592CrossRefGoogle Scholar
  12. Liu DM, Salem R, Bui JT et al (2005) Angiographic considerations in patients undergoing liver-directed therapy. J Vasc Interv Radiol 16:911–935PubMedCrossRefGoogle Scholar
  13. Makuchi M, Sukigara M, Mori T et al (1985) Bile duct necrosis: complication of transcatheter hepatic arterial embolization. Radiology 156:331–334Google Scholar
  14. Mantravadi RV, Spigos DG, Tan WS et al (1982) Intraarterial yttrium 90 in the treatment of hepatic malignancy. Radiology 142:783–786PubMedGoogle Scholar
  15. Nakamura H, Kondoh H (1986) Emphysematous cholecystitis: complications of hepatic arterial embolization. Cardiovasc Intervent Radiol 9:152–153PubMedCrossRefGoogle Scholar
  16. Northover JMA, Terblanche J (1979) A new look a the arterial supply of the bile duct in man and its surgical implications. Br J Surg 66:379–384PubMedCrossRefGoogle Scholar
  17. Park WK, Chang JC, Lee HZ, Kim HJ, Choi JH, Gu MJ (2002) A case of resection of biloma with hepatocellular carcinoma after embolization. TaehanKan Hakhoe Chi 8:331–335Google Scholar
  18. Sakamoto I, Iwanaga S, Nagaoki K et al (2003) Intrahepatic biloma formation (bile duct necrosis) after transcatheter arterial chemoembolization. AJR Am J Roentgenol 181:79–87PubMedCrossRefGoogle Scholar
  19. Salem R, Thurston KG (2006) Radioembolization with 90Yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. Part 1: technical and methodologic considerations. J Vasc Interv Radiol 17:1251–1278PubMedCrossRefGoogle Scholar
  20. Salem R, Lewandosky RJ, Atassi B et al (2005) Treatment of unresectable hepatocellular carcinoma with intrahepatic yttrium 90 microspheres: factors associated with liver toxicities. J Vasc Interv Radiol 16:1627–1639PubMedCrossRefGoogle Scholar
  21. Szyszko T, Al-Nahhas A, Tait P et al (2007) Management and prevention of adverse effects related to treatment of liver tumours with 90Y microspheres. Nucl Med Commun 28:21–24PubMedCrossRefGoogle Scholar
  22. Wollner IS, Knutsen CA, Ullrich KA et al (1987) Effects of hepatic arterial yttrium-90 microsphere administration alone and combined with regional bromodeoxyuridine infusion in dogs. Cancer Res 47:3285–3290PubMedGoogle Scholar
  23. Yip D, Allen R, Ashton C et al (2004) Radiation-induced ulceration of the stomach secondary to hepatic embolization with radioactive yttrium microspheres in the treatment of metastatic colon cancer. J Gastroenterol Hepatol 19:347–349PubMedCrossRefGoogle Scholar
  24. Yu JS, Kim KW, Jeong MG et al (2002) Predisposing factors of bile duct injury after transcatheter arterial chemoembolization for hepatic malignancy. Cardiovasc Intervent Radiol 25:270–274PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • R. T. Hoffmann
    • 1
  • Lourdes Diaz-Dorronsoro
    • 1
  • José I. Bilbao
    • 1
  1. 1.University Hospital DresdenDresdenGermany

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