Multiple Sclerosis and Other Demyelinating Diseases

  • Martin Bendszus
  • Brigitte Storch-Hagenlocher
Part of the Medical Radiology book series (MEDRAD)


Multiple sclerosis (MS) is the most frequent idiopathic inflammatory demyelinating disease of the central nervous system. Magnetic resonance imaging is the most important paraclinical parameter in the diagnosis of MS. If the MR criteria for dissemination in time and space are positive, the early diagnosis of MS may be established already after one clinical event; thus, MRI has an important impact on the initiation of early therapy in MS. Moreover, MRI is essential in monitoring disease activity and therapy effects. Atypical inflammatory demyelinating diseases include ADEM, neuromyelitis optica (Devic disease), Baló’s concentric sclerosis, Schilder’s disease, Marburg’s disease, tumefactive demyelinating lesions, and acute transverse myelitis. These entities may be separated from MS by a different clinical course and a particular appearance on MRI. Occasionally, these variants merge with MS.


Multiple Sclerosis Multiple Sclerosis Patient Glatiramer Acetate Cerebral Spinal Fluid Clinically Isolate Syndrome 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Martin Bendszus
    • 1
  • Brigitte Storch-Hagenlocher
    • 1
  1. 1.Division of NeuroradiologyUniversity of Heidelberg Medical CenterHeidelbergGermany

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