Other Epilepsy-Associated Diseases and Differential Diagnoses

Part of the Medical Radiology book series (MEDRAD)


This chapter summarizes (1) rare diseases with epilepsy as the core feature and a specific MRI pattern, (2) common diseases with specific clinical features but without epilepsy as the core feature, and (3) MRI changes associated with antiepileptic drug therapy.


Cerebellar Atrophy Cortical Lesion Retrograde Amnesia Epilepsy Syndrome Transient Global Amnesia 


  1. Al-Asmi A, Jansen AC, Badhwar A et al (2005) Familial temporal lobe epilepsy as a presenting feature of choreoacanthocytosis. Epilepsia 46:1256–1263PubMedCrossRefGoogle Scholar
  2. Arai M, Osaka H (2011) Acute leukoencephalopathy possibly induced by phenytoin intoxication in an adult patient with methylenetetrahydrofolate reductase deficiency. Epilepsia 52:e58–e61PubMedCrossRefGoogle Scholar
  3. Bader B, Vollmar C, Ackl N, Ebert A, la Fougere C, Noachtar S, Danek A (2011) Bilateral temporal lobe epilepsy confirmed with intracranial EEG electrodes in chorea–acanthocytosis. Seizure 20:340–342PubMedCrossRefGoogle Scholar
  4. Bartsch T, Deuschl G (2010) Transient global amnesia: functional anatomy and clinical implications. Lancet Neurol 9(2):205–214PubMedCrossRefGoogle Scholar
  5. Bartsch T, Alfke K, Stingele R, Rohr A, Freitag-Wolf S, Jansen O, Deuschl G (2006) Selective affection of hippocampal CA-1 neurons in patients with transient global amnesia without long-term sequelae. Brain 129(Pt 11):2874–2884PubMedCrossRefGoogle Scholar
  6. Bilo L, Meo R, Ruosi P, de Leva MF, Striano S (2009) Transient epileptic amnesia: an emerging late-onset epileptic syndrome. Epilepsia 50(Suppl 5):58–61PubMedCrossRefGoogle Scholar
  7. Brownell B, Hughes JT (1962) The distribution of plaques in the cerebrum in multiple sclerosis. J Neurol Neurosurg Psychiatry 25:315–320PubMedCrossRefGoogle Scholar
  8. Butler CR, Graham KS, Hodges JR, Kapur N, Wardlaw JM, Zeman AZ (2007) The syndrome of transient epileptic amnesia. Ann Neurol 61:587–598PubMedCrossRefGoogle Scholar
  9. Butler CR, Bhaduri A, Acosta-Cabronero J, Nestor PJ, Kapur N, Graham KS, Hodges JR, Zeman AZ (2009) Transient epileptic amnesia: regional brain atrophy and its relationship to memory deficits. Brain 132(Pt 2):357–368PubMedGoogle Scholar
  10. Calabrese M, De Stefano N, Atzori M et al (2008) Extensive cortical inflammation is associated with epilepsy in multiple sclerosis. J Neurol 255(4):581–586PubMedCrossRefGoogle Scholar
  11. Della Marca G, Dittoni S, Pilato F, Profice P, Losurdo A, Testani E, Colicchio S, Gnoni V, Colosimo C, Di Lazzaro V (2010) Teaching neuroimages: transient epileptic amnesia. Neurology 75(10):e47–e48PubMedCrossRefGoogle Scholar
  12. Dobson-Stone C, Velayos-Baeza A, Filippone LA et al (2004) Chorein detection for the diagnosis of chorea–acanthocytosis. Ann Neurol 56:299–302PubMedCrossRefGoogle Scholar
  13. Echlin F, Battista J (1963) Epileptiform seizures from chronic isolated cortex. Arch Neurol 9:154–170PubMedCrossRefGoogle Scholar
  14. Evans MD, Shinar R, Yaari R (2011) Reversible dementia and gait disturbance after prolonged use of valproic acid. Seizure 20(6):509–511PubMedCrossRefGoogle Scholar
  15. Fisher CM, Adams RD (1964) Transient global amnesia. Acta Neurol Scand 40:1–83Google Scholar
  16. Freemann JL, Coleman LT, Smith LJ, Shield LK (2002) Hemiconvulsion–hemiplegia–epilepsy syndrome: characteristic early magnetic resonance imaging findings. J Child Neurol 17:10–16CrossRefGoogle Scholar
  17. Gastaut H, Poirier F, Payan H, Salamon G, Toga M, Vigoroux M (1960) H.H.E. syndrome; hemiconvulsions, hemiplegia, epilepsy. Epilepsia 1:418PubMedCrossRefGoogle Scholar
  18. Geurts JJ, Bo L, Pouwels PJ et al (2005) Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology. AJNR 26:572–577PubMedGoogle Scholar
  19. Grubben B, De Jonghe P, Cras P, Demey HE, Parizel PM (2004) Valproate-induced hyperammonemic encephalopathy: imaging findings on diffusion-weighted MRI. Eur Neurol 52(3):178–181PubMedCrossRefGoogle Scholar
  20. Hamer HM, Dodel R, Strzelczyk A, Balzer-Geldsetzer M, Reese JP, Schöffski O, Graf W, Schwab S, Knake S, Oertel WH, Rosenow F, Kostev K (2012) Prevalence, utilization, and costs of antiepileptic drugs for epilepsy in Germany—a nationwide population-based study in children and adults. J Neurol 2012 Apr 28 [Epub ahead of print]Google Scholar
  21. Huppertz HJ, Kröll-Seger J, Danek A, Weber B, Dorn T, Kassubek J (2008) Automatic striatal volumetry allows for identification of patients with chorea–acanthocytosis at single subject level. J Neural Transm 115:1393–1400PubMedCrossRefGoogle Scholar
  22. Iyer RS, Chaturvedi A, Pruthi S, Khanna PC, Ishak GE (2011) Medication neurotoxicity in children. Pediatr Radiol 41:1455–1464PubMedCrossRefGoogle Scholar
  23. Jokeit H, Okujava M, Woermann FG (2001) Carbamazepine reduces memory induced activation of mesial temporal lobe structures: a pharmacological fMRI-study. BMC Neurol 18:1–6Google Scholar
  24. Jung HH, Danek A, Walker RH (2011) Neuroacanthocytosis syndromes. Orphanet J Rare Dis 6:68PubMedCrossRefGoogle Scholar
  25. Kallenberg K, Dehnert C, Dörfler A, Schellinger PD, Bailey DM, Knauth M, Bärtsch PD (2008) Microhemorrhages in nonfatal high-altitude cerebral edema. J Cereb Blood Flow Metab 28:1635–1642PubMedCrossRefGoogle Scholar
  26. Kapur N (1993) Transient epileptic amnesia—a clinical update and a reformulation. J Neurol Neurosurg Psychiat 56:1184–1190PubMedCrossRefGoogle Scholar
  27. Kelley BJ, Rodriguez M (2009) Seizures in patients with multiple sclerosis: epidemiology, pathophysiology and management. CNS Drugs 23:805–815PubMedCrossRefGoogle Scholar
  28. Kim SS, Chang KH, Kim ST et al (1999) Focal lesion in the splenium of the corpus callosum in epileptic patients: antiepileptic drug toxicity? AJNR Am J Neuroradiol 20:125–129PubMedGoogle Scholar
  29. Laxer KD, Robertson LT, Julien RM, Dow RS (1980) Phenytoin: relationship between cerebellar function and epileptic discharges. Adv Neurol 27:415–427PubMedGoogle Scholar
  30. Lebrun C (2006) Epilepsy and multiple sclerosis. Epileptic Disord 8:555–558Google Scholar
  31. Luef G, Chemelli A, Birbamer G, Aichner F, Bauer G (1994) Phenytoin overdosage and cerebellar atrophy in epileptic patients: clinical and MRI findings. Eur Neurol 34(Suppl 1):79–81PubMedCrossRefGoogle Scholar
  32. Nakada T, Kwee IL, Fujii Y, Knight RT (2005) High-field, T2-reversed MRI of the hippocampus in transient global amnesia. Neurology 64:1170PubMedCrossRefGoogle Scholar
  33. Nelles M, Bien CG, Kurthen M, von Falkenhausen M, Urbach H (2006) Transient splenium lesions in presurgical epilepsy patients: incidence and pathogenesis. Neuroradiology 48:443–448PubMedCrossRefGoogle Scholar
  34. Nicholas JM, Ridsdale L, Richardson MP, Ashworth M, Gulliford MC (2012) Trends in antiepileptic drug utilisation in UK primary care 1993–2008: Cohort study using the General Practice Research Database. Seizure 21(6):466–470Google Scholar
  35. Nicoletti A, Sofia V, Biondi R et al (2003) Epilepsy and multiple sclerosis in Sicily: a population-based study. Epilepsia 44:1445–1448PubMedCrossRefGoogle Scholar
  36. Nyquist PA, Cascino GD, Rodrigue M (2001) Seizures in patients with multiple sclerosis seen at Mayo Clinic, Rochster, Minn, 1990–1998. Mayo Clin Proc 76:983–986PubMedCrossRefGoogle Scholar
  37. Nyquist PA, Cascino GD, McClelland RL et al (2002) Incidence of seizures in patients with multiple sclerosis: a population-based study. Mayo Clin Proc 77:910–912PubMedGoogle Scholar
  38. Olafsson E, Benedikz J, Hauser WA (1999) Risk of epilepsy in patients with multiple sclerosis: a population-based study in Iceland. Epilepsia 40:745–747PubMedCrossRefGoogle Scholar
  39. Pearl PL, Vezina LG, Saneto RP et al (2009) Cerebral MRI abnormalities associated with vigabatrin therapy. Epilepsia 50:184–194PubMedCrossRefGoogle Scholar
  40. Schaffer AJ (1927) The etiology of infantile acquired hemiplegia. Arch Neurol Psychiatry 18:323CrossRefGoogle Scholar
  41. Scheid R, Bader B, Ott DV, Merkenschlager A, Danek A (2009) Development of mesial temporal lobe epilepsy in chorea–acanthocytosis. Neurology 73:1419–1422Google Scholar
  42. Sedlaczek O, Hirsch JG, Grips E, Peters CNA, Gass A, Wöhrle J, Hennerici M (2004) Detection of delayed focal MR changes in the lateral hippocampus in transient global amnesia. Neurology 62:2165PubMedCrossRefGoogle Scholar
  43. Simao GN, Zarei Mahmoodabadi S, Snead OC, Go C, Widjaja E (2011) Abnormal axial diffusivity in the deep gray nuclei and dorsal brain stem in infantile spasm treated with vigabatrin. AJNR Am J Neuroradiol 32:199–203PubMedGoogle Scholar
  44. Specht U, May TW, Rohde M, Wagner V, Schmidt RC, Schütz M, Wolf P (1997) Cerebellar atrophy decreases the threshold of carbamazepine toxicity in patients with chronic focal epilepsy. Arch Neurol 54(4):427–431Google Scholar
  45. Velayos-Baeza A, Vettori A, Copley RR, Dobson-Stone C, Monaco AP (2004) Analysis of the human VPS13 gene family. Genomics 84:536–549PubMedCrossRefGoogle Scholar
  46. Viveiros CD, Alvarenga RM (2010) Prevalence of epilepsy in a case series of multiple sclerosis patients. Arq Neuropsiquiatr 68:731–736PubMedCrossRefGoogle Scholar
  47. Zeman AZ, Boniface SJ, Hodges JR (1998) Transient epileptic amnesia: a description of the clinical and neuropsychological features in 10 cases and a review of the literature. J Neurol Neurosurg Psychiatry 64:435–443PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg  2013

Authors and Affiliations

  1. 1.Department of NeuroradiologyUniversity Hospital FreiburgFreiburgGermany

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