Effects of Music on the Psyche of Neuroendocrine Tumour Patients Undergoing Peptide Receptor Radionuclide Therapy

  • Remigius Orjiukwu
  • Margot Staudinger
  • Daniel Putzer
  • Dietmar Waitz
  • Michael Gabriel
  • Irene J. Virgolini
Part of the Medical Radiology book series (MEDRAD)


Radionuclide peptide receptor-based therapy (PRRT) is an established therapeutic option in inoperable metastatic neuroendocrine tumours (NETs), who show somatostatin receptor (SSTR) expression in SSTR scintigraphy. According to the Innsbruck protocol for performing PRRT our department for PRRT only few side effects are observed. PRRT is generally very well tolerated, and the results favour the combined use of radiolabeled SST analogues providing a customised therapy strategy for tumour control in advanced stages. Overall response rates (minor response, partial remission, stable disease) to PRRT are more than 75 %, and even in patients with progressive disease palliation of tumour-related symptoms may be observed. In patients with advanced disease stages, older age, poor Karnovsky performance index and diminished organ function due to pre-treatment with chemotherapy, radioactivity doses should be adapted to the individual situation. An improvement of quality of life parameters is documented in many of the NET patients reported by the EORTC questionnaire which covers the global well-being of the patient. PRRT is well established in the treatment of NET patients suffering progressive, metastatic disease. These patients are often confronted with the diagnosis of a growing tumor and only few well established treatment options. However, the treatment with high dose radioactivity is not commonly known and may cause a certain anxiety level. A correlation between music and human biology has been described and “music therapy” has been applied in different medical treatments. In a randomised controlled study, we examined the influence of systematic application of music via MP3 players on the psyche of NET patients undergoing PRRT. In both groups of patients receiving music or not, a statistically significant difference could be measured for the global severity index (i.e. a measure for the self-reported clinically relevant psychological symptoms) between the day of admittance and the day of remission from our therapy unit, but the effect was more pronounced in the music group. Furthermore, during application of PRRT a significant reduction of the acute anxiety level was observed in both groups, and this effect was more pronounced in the patient group receiving music, and was statistically significant after application of radioactivity between the music group and the control group. We conclude that selected music positively influences patient care by reducing the acute anxiety level during application of PRRT as well as by reducing clinically relevant psychological symptoms.


Religious Experience Music Therapy Peptide Receptor Radionuclide Therapy Global Severity Index Amino Acid Solution 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Remigius Orjiukwu
    • 1
  • Margot Staudinger
    • 1
  • Daniel Putzer
    • 1
  • Dietmar Waitz
    • 1
  • Michael Gabriel
    • 1
  • Irene J. Virgolini
    • 1
    • 2
  1. 1.Department of Nuclear MedicineMedical University of InnsbruckInnsbruckAustria
  2. 2.Universitätsklinik für NuklearmedizinInnsbruckAustria

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