Treatment of Lymphoma with 131I-Chimeric Monoclonal Antibodies

  • J. Harvey Turner
Part of the Medical Radiology book series (MEDRAD)


Radioimmunotherapy is a safe, effective treatment of low grade lymphoma and increases overall survival, whilst preserving quality of life. Efficacy is comparable with that of standard rituximab chemotherapy regimens and 131I-rituximab radioimmunotherapy is associated with less toxicity. Radioiodinated chimeric anti-CD 20 monoclonal antibody offers practical, cost-effective radioimmunotherapy for routine clinical applications where regulatory or cost constraints limit the availability of proprietary radiolabelled murine anti-CD 20 monoclonal antibodies. 131I-rituximab has, in addition, the potential for safe, effective, repeated radioimmunotherapy upon relapse of non-Hodgkin lymphoma.


Objective Response Rate Mantle Cell Lymphoma Beam Conditioning CD20 Positive Cell Line Hospital Nuclear Medicine 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.School of Medicine and Pharmacology, Department of Nuclear MedicineThe University of Western AustraliaFremantleAustralia

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