Radioimmunotherapy of Brain Tumors

Part of the Medical Radiology book series (MEDRAD)


Despite many technical advances (intraoperative resection control, fluorescence guided resection, advances in external beam radiation techniques) and new consolidated findings on systemic chemotherapy, treatment of malignant gliomas with conventional modalities (surgery, radiation therapy, and chemotherapy) is still highly unfavorable. Total tumor eradication is impossible due to tumor infiltrations into the surrounding normal brain tissue and the limitations given by its limited tolerance. New treatment strategies, therefore, aim for a more selective destruction of tumor cells. Malignant gliomas express several antigens or receptors which are not or only to a minor extent present in normal brain tissue. Administration of radiolabeled monoclonal antibodies targeting these tumor-specific structures, especially when given locoregionally, offers an innovative therapeutic strategy that has demonstrated encouraging antitumor effects and acceptable toxicity in many phase I/II clinical trials. This chapter offers a comprehensive summary of own experiences and results of clinical trials reported in the literature dealing with radioimmunotherapy of malignant glioma and highlights future plans to further develop this therapeutic strategy.


Epidermal Growth Factor Receptor Malignant Glioma Anaplastic Astrocytoma Neural Cell Adhesion Molecule Normal Brain Tissue 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Nuclear MedicineKatharinenhospital—Klinikum StuttgartStuttgartGermany

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