Endovascular Brachytherapy to Prevent Restenosis After Percutaneous Coronary Intervention

  • Jörg Kotzerke
  • Sigmund Silber
Part of the Medical Radiology book series (MEDRAD)


Radiation can prevent not only keloid scar formation at the skin but also an excess of intraluminal neointimal proliferation following injury of balloon angioplasty. This was demonstrated in animal models of restenosis and was validated in multiple clinical trials. Beta irradiation was as effective as gamma irradiation, however, low dose radioactive stents caused edge stenosis. Filling a balloon catheter with a radioactive solution (e.g. rhenium-188-perrhenate) restenosis could be prevented or at least delayed which was demonstrated in in-stent restenosis as well as in de novo stenosis. Late thrombosis of irradiated bare metal stents has been overcome by dual antiplatelet treatment for 12 months. Recommendations and standardizations for vascular brachytherapy were developed to secure this highly interdisciplinary approach. However, the interest in this technique vanished when drug-eluting stents were available which can be delivered by the interventionalist alone without the limitations and expenditure from application of irradiation. Nevertheless, intracoronary brachytherapy with isotope-filled balloons or beta radiation is still applied in some specialized centers.


Percutaneous Coronary Intervention Balloon Catheter Major Adverse Cardiac Event Bare Metal Stents Target Lesion Revascularization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg  2012

Authors and Affiliations

  1. 1.Klinik und Poliklinik für NuklearmedizinUniversitätsklinikum DresdenDresdenGermany
  2. 2.Kardiologische Praxis und Praxisklinik, Heart Center at the IsarMünchenGermany

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