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Radioimmunotherapy in Metastatic Colorectal Cancer

  • Johannes Meller
  • Torsten Liersch
  • Birgit Meller
  • Kia Homayounfar
  • Carsten-Oliver Sahlmann
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

Based on the recent results from first-line treatment of metastatic colorectal cancer that clearly display the limits of intensifying systemic 5FU-based chemotherapy, at least on the basis of established drugs like oxaliplatin and irinotecan in combination with biological agents, alternative anti-cancer strategies like radioimmunotherapy (RAIT) are needed to be evaluated. However, in contrast to the encouraging results of RAIT in several preclinical colorectal cancer models, the efficacy of this method in patients with metastatic disease remains disappointing. Therefore, our group has focused on anti-CEA RAIT with 131I-Labetuzumab in patients post-salvage resection of CEA-expressing colorectal cancer liver metastases (CRC-LM). In phase I/II-trials both, the single and repeated application of 131I-Labetuzumab has been proven to be safe and feasible with acceptable side effects and high patient compliance. The disease-free survival and overall survival were significantly prolonged compared to matched contemporaneous control groups without RAIT treated at the same institution by identical surgeons during the same time period. Anti-CEA RAIT with 131I-Labetuzumab, as a targeted systemic therapy, offers a new, potent strategy for the “pseudoadjuvant” treatment of patients with CRC-LM. In the near future, further improvement is awaited by the implementation of pretargeting strategies.

Keywords

Overall Survival Maximum Tolerate Dose Medullary Thyroid Cancer Epithelial Cell Adhesion Molecule Murine Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Johannes Meller
    • 1
  • Torsten Liersch
    • 2
  • Birgit Meller
    • 3
  • Kia Homayounfar
    • 2
  • Carsten-Oliver Sahlmann
    • 4
  1. 1.Abteilung Nuklearmedizin, Zentrum RadiologieGeorg-August-Universität GöttingenGöttingenGermany
  2. 2.Abteilung Allgemein- und Viszeralchirurgie, Zentrum ChirurgieGeorg-August-Universität GöttingenGöttingenGermany
  3. 3.Klinik für NuklearmedizinZentrum Radiologie; Georg-August-Universität Göttingen and Martin-Luther-Universität Halle/SaaleGöttingenGermany
  4. 4.Abteilung Nuklearmedizin, Zentrum RadiologieGeorg-August-Universität GöttingenGöttingenGermany

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