Radionuclide Therapy for Bleeding Joints in Hemophilia

  • Emerita Andres-Barrenechea
  • Mary Chua
  • Sandra Navarra
Part of the Medical Radiology book series (MEDRAD)


Radiosynovectomy is the local intraarticular injection of radionuclides (Yttrium–90, Rhenium-186, P-32, Erbium-169), which are thought to be rapidly phagocytosed by synoviocytes, and then distributed within the surface of the synovium causing vasculitis and occluding the microvascular supply. This, in addition to the cytotoxic effect of radiation, results in ablation of the synovium. This procedure needs only 30 % coagulopathy among hemophilics. With the overall improvement of 80−92% in most studies, it must be the procedure of choice for hemophilics with repeated bleeding and in those where surgery cannot be done. It should be considered for hemophilics with joint disease not responsive to replacement therapy and for those whom surgical synovectomy pose too many risks.


Factor VIII Radionuclide Therapy Hemophilic Patient Coagulation Factor VIII Chronic Synovitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Emerita Andres-Barrenechea
    • 1
  • Mary Chua
    • 2
  • Sandra Navarra
    • 3
  1. 1.Department of Nuclear Medicine and PETSt. Luke’s Medical CenterQuezon CityPhilippines
  2. 2.Department of PediatricsCardinal Santos Medical Center..
  3. 3.Rheumatology SectionSt. Luke’s Medical Center..

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