Radionuclide Therapy of Bone Metastases Using Rhenium-188 Hydroxyethylidene Diphosphonate

  • Jan Bucerius
  • Holger Palmedo
  • Hans-Jürgen Biersack
Part of the Medical Radiology book series (MEDRAD)


Many solid malignant tumors, mainly prostate, breast, and lung cancer, generate bone metastases throughout the course of disease. They can lead to serious complications of which chronic pain syndrome is the most important and frequent one, having a negative impact on quality of life and the social environment of the patient. Radionuclide therapy of bone metastases was introduced decades ago as a therapeutic option for patients suffering from painful bone metastases. Out of several radiopharmaceuticals, which are or have been used for this purpose, Rhenium-188 hydroxyethylidene diphosphonate (Re-188 HEDP) is a relatively new and, mainly because of its physical properties, attractive alternative. It localizes in skeletal metastases and emits beta particles and was previously shown to be beneficial for the palliative treatment of metastatic bone disease. In this chapter, the methodology of Re-188 HEDP treatment as well as clinical studies and new treatment strategies involving Re-188 HEDP are discussed in order to provide a detailed overview of this treatment option for patients suffering from bone metastases.


Bone Metastasis Prostate Cancer Patient Skeletal Metastasis Radionuclide Therapy Karnofsky Performance Scale 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Jan Bucerius
    • 1
    • 2
    • 3
  • Holger Palmedo
    • 4
  • Hans-Jürgen Biersack
    • 5
  1. 1.Department of Nuclear MedicineMaastricht University Medical CenterMaastrichtThe Netherlands
  2. 2.Cardiovascular Research Institute Maastricht (CARIM)Maastricht University Medical CenterMaastrichtThe Netherlands
  3. 3.Department of Nuclear MedicineUniversity Hospital RWTH AachenAachenGermany
  4. 4.Department of Nuclear MedicineInstitute of Radiology and Nuclear Medicine Kaiserstraße BonnBonnGermany
  5. 5.Department of Nuclear MedicineUniversity of BonnBonnGermany

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