Coeliac Disease

  • Mirella Fraquelli
Part of the Medical Radiology book series (MEDRAD)


Celiac disease is a common immune-mediated enteropathy that occurs in genetically predisposed individuals following the ingestion of gluten, a protein found in foods processed from wheat and related grain species. In this chapter an overview is provided regarding the most frequent ultrasonographic findings observed in association with the disease.


Celiac Disease Coeliac Disease Celiac Disease Patient Small Bowel Adenocarcinoma Celiac Disease Diagnosis 
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  1. Aliotta A, Pompili M, Rapaccini GL et al (1997) Doppler ultrasonographic evaluation of blood flow in the superior mesenteric artery in celiac patients and in healthy controls in fasting conditions and after saccharose. J Ultrasound Med 16:85–91PubMedGoogle Scholar
  2. Arienti V, Califano C, Brusco G et al (1996) Doppler ultrasonographic evaluation of splanchnic blood flow in coeliac disease. Gut 39:369–373PubMedCrossRefGoogle Scholar
  3. Armstrong MJ, Hegade VS, Robins G (2012) Advances in celiac disease. Curr Opin Gastroenterol 28:104–112PubMedCrossRefGoogle Scholar
  4. Bahlouli F, Seror O, Mathieu E et al (1998) Mesenteric lymph node cavitation disclosing celiac disease in adults. J Radiol 79:431–433PubMedGoogle Scholar
  5. Bardella MT, Trovato C, Quatrini M, Conte D (1999) Mesenteric lymph node cavitation: a rare hallmark of celiac disease. Scand J Gastroenterol 34:1257–1259PubMedCrossRefGoogle Scholar
  6. Bardella MT, Fraquelli M, Peracchi M et al (2000) Gastric emptying and plasma neurotensin levels in untreated celiac patients. Scand J Gastroenterol 35:269–273PubMedCrossRefGoogle Scholar
  7. Bartusek D, Valek V, Husty J, Uteseny J (2007) Small bowel ultrasound in patients with celiac disease. Retrospective study. Eur J Radiol 63:302–306PubMedCrossRefGoogle Scholar
  8. Benini L, Sembenini C, Salandini L et al (2001) Gastric emptying of realistic meals with and without gluten in patients with coeliac disease. Effect of jejunal mucosal recovery. Scand J Gastroenterol 36:1044–1048PubMedCrossRefGoogle Scholar
  9. Benini F, Morea A, Turini D et al (2011) Slow gallbladder emptying reverts to normal but small intestine transit of a physiological meal remains slow in celiac patients during gluten-free diet. Neurogastroenterol Motil 20 (in press)Google Scholar
  10. Brown AM, Bradshaw MJ, Richardson R et al (1987) Pathogenesis of the impaired gall bladder contraction of coeliac disease. Gut 28:1426–1432PubMedCrossRefGoogle Scholar
  11. Burrell HC, Trescoli C, Chow K, Ward MJ (1994) Case report: mesenteric lymph node cavitation, an unusual complication of coeliac disease. Br J Radiol 67:1139–1140PubMedCrossRefGoogle Scholar
  12. Castiglione F, Rispo A, Cozzolino A et al (2007) Bowel sonography in adult celiac disease:diagnostic accuracy and ultrasonographic features. Abdom Imaging 32:73–77PubMedCrossRefGoogle Scholar
  13. Catassi C, Bearzi I, Holmes GK (2005) Association of celiac disease and intestinal lymphomas and other cancers. Gastroenterology 128:S79–S86PubMedCrossRefGoogle Scholar
  14. Cohen MD, Lintott DJ (1978) Transient small bowel intussusception in adult coeliac disease. Clin Radiol 29:529–534PubMedCrossRefGoogle Scholar
  15. Delamarre J, Capron JP, Joly JP et al (1984) Gallbladder inertia in celiac disease: ultrasonographic demonstration. Dig Dis Sci 29:876–877PubMedCrossRefGoogle Scholar
  16. Dell’Aquila P, Petrini L, Barone M et al (2005) Small intestine contrast ultrasonography-based scoring system: a promising approach for the diagnosis and follow-up of celiac disease. J Clin Gastroenterol 39:591–595PubMedCrossRefGoogle Scholar
  17. Dodds WJ, Groh WJ, Darweesh RMA et al (1985) Sonographic measurement of gallbladder volume. Am J Roentgenol 145:1009–1011CrossRefGoogle Scholar
  18. Farrell LJ, Kelly CP (2002) Celiac sprue. N Engl J Med 346:180–188PubMedCrossRefGoogle Scholar
  19. Fraquelli M, Colli A, Colucci A et al (2004) Accuracy of ultrasonography in predicting celiac disease. Arch Intern Med 164:169–174PubMedCrossRefGoogle Scholar
  20. Fraquelli M, Bardella MT, Peracchi M et al (1999) Gallbladder emptying and somatostatin and cholecystokinin plasma levels in celiac disease. Am J Gastroenterol 94:1866–1870PubMedCrossRefGoogle Scholar
  21. Fraquelli M, Pagliarulo M, Colucci A et al (2003) Gallbladder motility in obesity, diabetes mellitus and coeliac disease. Digest Liver Dis 35:S12–S16CrossRefGoogle Scholar
  22. Freeman HJ, Chopra A, Clandinin MT et al (2011) Recent advances in celiac disease. World J Gastroenterol 17:2259–2272PubMedCrossRefGoogle Scholar
  23. Giovagnorio F, Picarelli A, Di Giovambattista F, Mastracchio A (1998) Evaluation with Doppler sonography of mesenteric blood flow in celiac disease. Am J Roentgenol 171:629–632CrossRefGoogle Scholar
  24. Gonzalez JA, Gonzalez JB, Crespo MJ, Sancho CI (1998) Acute gallbladder distension and recurrent small bowel intussusception in a child with celiac disease. J Pediatr Gastroenterol Nutr 27:444–445PubMedCrossRefGoogle Scholar
  25. Hec F, Vernier-Massouille G, Mariette C (2012) Recurrent small bowel intussusceptions in coeliac disease (in press)Google Scholar
  26. Hin H, Bird G, Fisher P et al (1999) Coeliac disease in primary care: case finding study. BMJ 318:164–167PubMedCrossRefGoogle Scholar
  27. Holmes GK, Stokes PL, Sorahan TM et al (1976) Coeliac disease, gluten-free diet and malignancy. Gut 17:612–619PubMedCrossRefGoogle Scholar
  28. Hopman WP, Rosenbusch G, Hectors MP, Jansen JB (1995) Effect of pre-digested fat on intestinal stimulation of plasma cholecystokinin and gallbladder motility in coeliac disease. Gut 36:17–21PubMedCrossRefGoogle Scholar
  29. Lionetti E, Catassi C (2010) New clues in celiac disease epidemiology, pathogenesis, clinical manifestations, and treatment. Int Rev Immunol 30:219–231CrossRefGoogle Scholar
  30. Logan RF, Rifkind EA, Turner ID, Ferguson A (1989) Mortality in celiac disease. Gastroenterology 97:265–271PubMedGoogle Scholar
  31. Low-Beer TS, Harvey RF, Davies ER, Read AF (1975) Abnormalities of serum cholecystokinin and gallbladder emptying in celiac disease. N Engl J Med 292:961–963PubMedCrossRefGoogle Scholar
  32. Maconi G, Radice E, Greco S et al (2007) Transient small-bowel intussusceptions in adults: significance of ultrasonographic detection. Clin Radiol 62:792–797PubMedCrossRefGoogle Scholar
  33. Magalotti D, Volta U, Bonfiglioli A et al (2003) Splanchnic haemodynamics in patients with coeliac disease: effects of a gluten-free diet. Digest Liver Dis 35:262–268CrossRefGoogle Scholar
  34. Masclee AA, Jansen JB, Driessen WM et al (1991) Gallbladder sensitivity to cholecystokinin in coeliac disease. Correlation of gallbladder contraction with plasma cholecystokinin-like immunoreactivity during infusion of cerulein. Scand J Gastroenterol 26:1279–1284PubMedCrossRefGoogle Scholar
  35. Maton PN, Selden AC, Fitzpatrick ML, Chadwick VS (1985) Defective gallbladder emptying and cholecystokinin release in celiac disease. Reversal by gluten-free diet. Gastroenterology 88:391–396Google Scholar
  36. McBride OM, Skipworth RJ, Leitch D, Yalamarthi S (2010) Cavitating mesenteric lymph node syndrome in association with coeliac disease and enteropathy associated T-cell lymphoma: a case report and review of the literature. Case Report Med 2010:478269Google Scholar
  37. Mushraq N, Marven S, Walker J et al (1999) Small bowel intussusception in celiac disease. J Pediatr Surg 3:1833–1835CrossRefGoogle Scholar
  38. Peck RJ, Jackson A, Gleeson D (1997) Case report: ultrasound of coeliac disease with demonstration of response to treatment. Clin Radiol 52:244–245PubMedCrossRefGoogle Scholar
  39. Reddy D, Salomon C, Demos TC (2002) Mesenteric lymph node cavitation in celiac disease. Am J Roentgenol 178:247CrossRefGoogle Scholar
  40. Rettenbacher T, Hollerweger A, Macheiner P et al (1999) Adult celiac disease: US signs. Radiology 211:389–394PubMedGoogle Scholar
  41. Rewers M (2005) Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease? Gastroenterology 128:S47–S51PubMedCrossRefGoogle Scholar
  42. Riccabona M, Rossipal E (1993) Sonographic findings in celiac disease. J Pediatr Gastroenterol Nutr 17:198–200PubMedCrossRefGoogle Scholar
  43. Rostom A, Dube C, Cranney A et al (2005) The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology 128:S38–S46PubMedCrossRefGoogle Scholar
  44. Sackett DL, Haynes RB (2002) The architecture of diagnostic research. BMJ 324:539–541PubMedCrossRefGoogle Scholar
  45. Swinson CM, Slavin G, Coles EC, Booth CC (1983) Coeliac disease and malignancy. Lancet 8316:111–115CrossRefGoogle Scholar
  46. Soresi M, Pirrone G, Giannitrapani I et al (2011) A key role for abdominal ultrasound examination in “difficult” diagnoses of celiac disease. Ultraschall Med 32:S53–S61PubMedCrossRefGoogle Scholar
  47. Tursi A (2004) Gastrointestinal motility disturbances in celiac disease. J Clin Gastroenterol 38:642–645PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Seconda Divisione Gastroenterologia, IRCCS Fondazione Cà Granda Ospedale Maggiore, Policlinico di MilanoUniversità degli Studi di MilanoMilanoItaly

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