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Osteoporosis and Bone Densitometry Measurements pp 5–13Cite as

Therapy of Osteoporosis

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Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

The goal of any osteoporosis therapy is the prevention of both vertebral and nonvertebral fractures, which in principle can be achieved by inhibiting bone resorption and/or by stimulating bone formation. There are currently several osteoporosis treatment options that may be suitable for various patient populations, including oral and IV bisphosphonates, SERMs, calcitonin, teriparatide, strontium ranelate, and denosumab. The choice of osteoporosis therapy should be individualized based on consideration of the efficacy, safety, cost, convenience (i.e., dosing regimen and delivery), and other non-osteoporosis-related benefits associated with each agent. Given the limitations of current antiosteoporosis drugs, a search for new therapeutics has focused in the last few years on also identifying novel antiresorptives that prevent the decrease in activation frequency and bone formation and on bone anabolics that increase bone formation directly without affecting bone resorption. It will be important to incorporate new and emerging agents into this individualized treatment paradigm to optimize clinical outcomes in patients with osteoporosis.

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  1. Department of Internal Medicine and Medical Disciplines, University of Rome “Sapienza”, Viale del Policlinico 155, 00161, Rome, Italy

    Salvatore Minisola & Elisabetta Romagnoli

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  1. Salvatore Minisola
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Correspondence to Salvatore Minisola .

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  1. , Department of Radiology, University of Foggia, Viale Luigi Pinto 1, Foggia, 71100, Italy

    Giuseppe Guglielmi

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Minisola, S., Romagnoli, E. (2013). Therapy of Osteoporosis. In: Guglielmi, G. (eds) Osteoporosis and Bone Densitometry Measurements. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_651

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