Normal Tissue Constraints

  • Simon S. Lo
  • Arjun Sahgal
  • Lijun Ma
  • Ben J. Slotman
  • Zhibin Huang
  • Nina A. Mayr
  • Charles A. Kunos
  • Bin S. Teh
  • Mitchell Machtay
  • Eric L. Chang
Part of the Medical Radiology book series (MEDRAD)


The use of SBRT for the treatment of various primary and metastatic tumors has increased exponentially in the past 10 years. To achieve a favorable therapeutic ratio, it is crucial to respect the tolerance of various organs-at-risk (OARs). There is a fair amount of studies with dosimetric correlation to toxicities of various organs in the literature. This chapter will provide an overview of normal tissue constraints for ablative radiation dose range based on studies with dosimetric parameters correlating with toxicities in the literature. The dose constraints used in clinical trials being conducted in the North America and Europe will also be reviewed.


Stereotactic Body Radiation Therapy Radiation Therapy Oncology Group Radiation Pneumonitis Normal Tissue Complication Probability Dosimetric Parameter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Simon S. Lo
    • 1
  • Arjun Sahgal
    • 2
  • Lijun Ma
    • 3
  • Ben J. Slotman
    • 4
  • Zhibin Huang
    • 5
  • Nina A. Mayr
    • 6
  • Charles A. Kunos
    • 1
  • Bin S. Teh
    • 7
  • Mitchell Machtay
    • 1
  • Eric L. Chang
    • 8
  1. 1.Department of Radiation OncologyUniversity Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve UniversityClevelandUSA
  2. 2.Department of Radiation Oncology, Princess Margaret Hospital and Toronto Sunnybrook HospitalUniversity of TorontoTorontoCanada
  3. 3.Department of Radiation OncologyUniversity of California San FranciscoSan FranciscoUSA
  4. 4.Department of Radiation OncologyVU University Medical CenterAmsterdamThe Netherlands
  5. 5.Department of Radiation OncologyEast Carolina UniversityGreenvilleUSA
  6. 6.Department of Radiation OncologyArthur G. James Cancer Hospital, The Ohio State UniversityColumbusUSA
  7. 7.Department of Radiation OncologyWeill Cornell College of Medicine The Methodist Hospital Cancer CenterHoustonUSA
  8. 8.Department of Radiation Oncology, Keck School of Medicine and Norris Cancer HospitalUniversity of Southern CaliforniaLos AngelesUSA

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