Metastatic Disease

  • Patrick J. Peller
Part of the Medical Radiology book series (MEDRAD)


This chapter reviews PET/PET identification of metastatic disease, the main cause of cancer deaths. More than one‐third of newly diagnosed cancer patients have metastases detectable by PET/CT. There are three major pathways by which tumor cells disseminate: blood borne, lymphatic spread, and by seeding body cavities. The primary tumor location and histology in large part determines the most common route and frequency of metastasis. Increased FDG uptake in metastases permits identification on PET/CT. Cancer of unknown primary site is a relatively common clinical entity, resulting from a wide variety of primary sites. PET/CT identification of the primary tumor allows for focused therapy and potentially improved survival.


Liver Metastasis Brain Metastasis Pulmonary Metastasis Adrenal Metastasis Adrenal Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of RadiologyMayo ClinicRochesterUSA

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