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MRI-Guided Stem Cell Therapy

  • Tina Ehtiati
  • Dara L. Kraitchman
Part of the Medical Radiology book series (MEDRAD)

Abstract

In the past several decades, there has been great interest in the transplantation of stem cells to recapitulate organs with limited regenerative capacity. During this same period, the ability to image stem cells by labeling with MRI-visible contrast agents has proved to be an enabling technology for determining the engraftment and fate of these cells. A natural extension of MR-labeling of stem cells is the delivery of stem cells using MR interventional techniques. While the development of these interventional techniques is hindered in part by the need to develop user-friendly imaging interfaces, MR-compatible devices, and advanced physiologic monitoring capabilities, limited clinical trials with MR-labeled stem cells have been performed that suggest MR interventional techniques will offer a safe and more effective method to deliver the stem cell therapies.

Keywords

Stem Cell Reporter Gene Stem Cell Therapy Chemical Exchange Saturation Transfer Stem Cell Delivery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Siemens Corporate ResearchCenter for Applied Medical ImagingBaltimoreUSA
  2. 2.Russell H. Morgan Department of Radiology and Radiological Science, Department of Molecular and Comparative PathobiologyJohns Hopkins UniversityBaltimoreUSA

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