Morphometric MRI Analysis

Part of the Medical Radiology book series (MEDRAD)


Morphometric MRI analysis may facilitate the detection and visualization of focal cortical dysplasia and other potentially epileptogenic cortical malformations by highlighting structural alterations such as abnormal gyration, blurring of the gray-white matter junction, and abnormal thickness of the cortical ribbon. In this chapter, a voxel-based implementation of this kind of MRI postprocessing using algorithms of the SPM5 software is presented. The description of methods is accompanied by illustrative examples which show how this approach may aid in the detection of subtle cortical dysplasia, polymicrogyria and gray matter heterotopia, in the delineation of the extent of lesions, and in the differentiation between different types of lesions. Thereby, it increases the diagnostic yield of MRI and appears to be a useful additional tool in the diagnostics and especially presurgical evaluation of epilepsy patients.  


Focal Cortical Dysplasia Normal Database Focal Cortical Dysplasia Type Thickness Image Periventricular Nodular Heterotopia 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Swiss Epilepsy CentreZurichSwitzerland

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