SPECT and PET
Ictal perfusion single photon emission computed tomography and positron emission tomography of brain metabolism are functional nuclear imaging modalities that are useful in the presurgical evaluation of patients with refractory focal epilepsy, and provide information on the ictal onset zone, seizure propagation pathways, and functional deficit zones. Combined with electrophysiological and coregistered MRI data, these techniques allow a noninvasive presurgical evaluation in a growing number of patients with refractory focal epilepsy, and are particularly useful in patients with normal MRI findings, focal dysplastic lesions, dual pathology and discordant seizure symptoms, and electrophysiology and morphological data. In addition, these techniques may provide crucial information in the planning of invasive electroencephalography studies.
KeywordsPositron Emission Tomography Single Photon Emission Compute Tomography Temporal Lobe Epilepsy Epilepsy Surgery Hippocampal Sclerosis
- Chang EF, Wang DD, Barkovich AJ et al (2011) Predictors of seizure freedom after surgery for malformations of cortical development. Ann Neurol 70:151–162Google Scholar
- Goffin K, Van Paesschen W, Dupont P et al (2010) Anatomy-based reconstruction of FDG-PET images with implicit partial volume correction improves detection of hypometabolic regions in patients with epilepsy due to focal cortical dysplasia diagnosed on MRI. Eur J Nucl Med Mol Imaging 37:1148–1155PubMedCrossRefGoogle Scholar