Abstract
MRI in children with epilepsies is different for mainly two reasons: 1) Children are generally unable to lie still for MRI. In order to acquire high-resolution MR images general anaesthesia is the preferred sedation method. 2) Ongoing myelination during the first two or three years of life make MR interpretation difficult. In the first 6 months of life, high resolution T2-weighted images have the highest diagnostic potential. During the phase of signal reversal (between 6 and 18 months of age) it may be difficult to detect epileptogenic lesions. If a MRI scan is “negative” at this age, it should be repeated after the age of 2 or 3.
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References
Barkovich AJ (2000) Concepts of myelin and myelination in neuroradiology. AJNR Am J Neuroradiol 21(6):1099–1109
Barkovich AJ, Kjos BO, Jackson DE Jr, Norman D (1988) Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T. Radiology 166(1 Pt 1):173–180
Bernal B, Altman NR (2003) Evidence-based medicine: neuroimaging of seizures. Neuroimaging Clin N Am 13(2):211–224
Caraballo R, Cersosimo R, Galicchio S, Fejerman N (1997a) Benign infantile familial convulsions. Rev Neurol 25 (141):682–684
Caraballo RH, Cersosimo RO, Medina CS, Tenembaum S, Fejerman N (1997b) Idiopathic partial epilepsy with occipital paroxysms. Rev Neurol 25 (143):1052–1058
Cepeda C, Andre VM, Levine MS, Salamon N, Miyata H, Vinters HV, Mathern GW (2006) Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis. Epilepsy Behav 9(2):219–235. doi:10.1016/j.yebeh.2006.05.012
Cox RG, Levy R, Hamilton MG, Ewen A, Farran P, Neil SG (2011) Anesthesia can be safely provided for children in a high-field intraoperative magnetic resonance imaging environment. Paediatr Anaesth 21(4):454–458. doi:10.1111/j.1460-9592.2011.03528.x
Elster AD, Mirza W (1991) Mr imaging in chronic partial epilepsy: role of contrast enhancement. AJNR Am J Neuroradiol 12(1):165–170
Eltze CM, Chong WK, Bhate S, Harding B, Neville BG, Cross JH (2005) Taylor-type focal cortical dysplasia in infants: some MRI lesions almost disappear with maturation of myelination. Epilepsia 46(12):1988–1992. doi:10.1111/j.1528-1167.2005.00339.x
Falconer MA, Serafetinides EA, Corsellis JA (1964) Etiology and pathogenesis of temporal lobe epilepsy. Arch Neurol 10:233–248
Gaillard WD, Chiron C, Cross JH, Harvey AS, Kuzniecky R, Hertz-Pannier L, Vezina LG (2009) Guidelines for imaging infants and children with recent-onset epilepsy. Epilepsia 50(9):2147–2153. doi:10.1111/j.1528-1167.2009.02075.x
King MA, Newton MR, Jackson GD, Fitt GJ, Mitchell LA, Silvapulle MJ, Berkovic SF (1998) Epileptology of the first-seizure presentation: a clinical, electroencephalographic, and magnetic resonance imaging study of 300 consecutive patients. Lancet 352(9133):1007–1011. doi:10.1016/S0140-6736(98)03543-0
Olafsson E, Ludvigsson P, Gudmundsson G, Hesdorffer D, Kjartansson O, Hauser WA (2005) Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. Lancet Neurol 4(10):627–634. doi:10.1016/S1474-4422(05)70172-1
Osborne JP, Lux AL, Edwards SW, Hancock E, Johnson AL, Kennedy CR, Newton RW, Verity CM, O’Callaghan FJ (2010) The underlying etiology of infantile spasms (West syndrome): information from the United Kingdom Infantile Spasms Study (UKISS) on contemporary causes and their classification. Epilepsia 51(10):2168–2174. doi:10.1111/j.1528-1167.2010.02695.x
Pinto Gama HP, da Rocha AJ, Braga FT, da Silva CJ, Maia AC Jr, de Campos Meirelles RG, Mendonca do RJI, Lederman HM (2006) Comparative analysis of MR sequences to detect structural brain lesions in tuberous sclerosis. Pediatr Radiol 36(2):119–125. doi:10.1007/s00247-005-0033-x
Rugg-Gunn FJ, Eriksson SH, Boulby PA, Symms MR, Barker GJ, Duncan JS (2003) Magnetization transfer imaging in focal epilepsy. Neurology 60(10):1638–1645
Schijns OE, Bien CG, Majores M, von Lehe M, Urbach H, Becker A, Schramm J, Elger CE, Clusmann H (2011) Presence of temporal gray-white matter abnormalities does not influence epilepsy surgery outcome in temporal lobe epilepsy with hippocampal sclerosis. Neurosurgery 68 (1):98–106; discussion 107. doi:10.1227/NEU.0b013e3181fc60ff
Schulte-Uentrop L, Goepfert MS (2010) Anaesthesia or sedation for MRI in children. Curr Opin Anaesthesiol 23(4):513–517. doi:10.1097/ACO.0b013e32833bb524
van der Knaap M, Valk J (1990) MR imaging of the various stages of normal myelination during the first year of life. Neuroradiology 31(6):459–470
van der Knaap M, Valk J (2005) Magnetic resonance of myelination and myelin disorders. Springer Berlin Heidelberg, New York, pp 1–19
Vezina LG (2011) MRI-negative epilepsy: protocols to optimize lesion detection. Epilepsia 52(Suppl 4):25–27. doi:10.1111/j.1528-1167.2011.03147.x
Woermann FG, Vollmar C (2009) Clinical MRI in children and adults with focal epilepsy: a critical review. Epilepsy Behav 15(1):40–49. doi:10.1016/j.yebeh.2009.02.032
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Sassen, R., Urbach, H. (2013). MRI of Children. In: Urbach, H. (eds) MRI in Epilepsy. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_560
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DOI: https://doi.org/10.1007/174_2012_560
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