Haematological Bone Marrow Malignancies

  • Sung Kim
  • Kathleen Carrigan
  • Michael Mulligan
Part of the Medical Radiology book series (MEDRAD)


Lymphoproliferative disorders and myeloproliferative disorders frequently involve the skeletal system. Lymphoma of bone might occur as primary lymphoma of bone or as secondary involvement in Hodgkin or Non-Hodgkin disease. Lymphoma of bone usually occurs as an area of osteolysis or as a focal sclerotic lesion with tumor-like signal behavior in MRI. Leukemias as well as chronic myeloproliferative diseases usually show homogeneous diffuse hypercellularity with low signal intensity on T1-w SE images and diffuse hyperintensity in fat-suppressed images. Usually the lesions show marked contrast enhancement. After systemic chemotherapy or in the later stages of disease, due to myelofibrosis, the signal might become more patchy. The findings are nonspecific, however with the knowledge of the clinical data they can be interpreted correctly. Osteomyelosclerosis has a different signal behavior with low signal intensity in all sequences. However, due to enlarged sinusoids contrast enhancement might be intense.


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Chronic Lymphocytic Leukemia Acute Leukemia Polycythemia Vera 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of RadiologyUMMCBaltimoreUSA

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