Skip to main content

CT Scanning in Pregnancy

  • Chapter
  • 2242 Accesses

Part of the Medical Radiology book series (Med Radiol Diagn Imaging)

Abstract

CT evaluation of pregnant patients with medical conditions not related to pregnancy is a valuable and reliable tool, but poses a recurring dilemma on the other hand due to radiation exposure concern for both mother and fetus. Maternal exposure is substantial including the exposure of breast tissue, highly sensitive during radiation, with a potential to increase relative risk for breast cancer over lifetime. Fetal exposure may theoretically lead to congenital malformations, and despite no known risks for development of congenital malformations or mental retardation in a fetus exposed to ionizing radiation at the MDCT levels typically used for diagnostic imaging, there is still a theoretical risk of carcinogenesis. An understanding of fetal and maternal effects of ionizing radiation by different CT protocols at different stages of gestation is essential for proper administration of the CT examinations in patients with non-obstetric conditions. Understanding of basic principles of maternal and fetal dosimetry is also essential for quality assurance. The approach to the informed consent and administration of iodinated intravenous contrast are also essential and discussed in this chapter. Available MDCT protocols and effective methods for radiation dose reduction are discussed for specific clinical conditions such as: pulmonary embolism, acute appendicitis, urolithiasis, and trauma.

Keywords

  • Pregnant Patient
  • Adaptive Statistical Iterative Reconstruction
  • Automatic Exposure Control
  • Suspected Pulmonary Embolism
  • Metal Oxide Semiconductor Field Effect Transistor

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • American College of Radiology (2004) Committee on Drugs and Contrast Media. Manual on contrast media, 6th ed. Reston, VA, pp 61–66

    Google Scholar 

  • American College of Radiology (2008) ACR practice guideline for imaging pregnant or potentially pregnant adolescents and women with ionizing radiation. American College of Radiology, Reston

    Google Scholar 

  • Ames Castro M, Shipp TD, Castro EE, Ouzounian J, Rao P (2001) The use of helical computed tomography in pregnancy for the diagnosis of acute appendicitis. Am J Obstet Gynecol 184:954–957

    CrossRef  PubMed  CAS  Google Scholar 

  • Andreou AK, Curtin JJ, Wilde S, Clark A (2008) Does pregnancy affect vascular enhancement in patients undergoing CT pulmonary angiography? Eur Radiol 18:2716–2722

    CrossRef  PubMed  Google Scholar 

  • Angel E, Wellnitz CV, Goodsitt MM et al (2008) Radiation dose to the fetus for pregnant patients undergoing multidetector CT imaging: Monte Carlo simulations estimating fetal dose for a range of gestational age and patient size. Radiology 249:220–227

    CrossRef  PubMed  Google Scholar 

  • Angel E, Yaghmai N, Jude CM et al (2009a) Monte Carlo simulations to assess the effects of tube current modulation on breast dose for multidetector CT. Phys Med Biol 54:497–512

    CrossRef  PubMed  Google Scholar 

  • Angel E, Yaghmai N, Jude CM et al (2009b) Dose to radiosensitive organs during routine chest CT: effects of tube current modulation. AJR 193:1340–1345

    CrossRef  PubMed  Google Scholar 

  • Atwell TD, Lteif AN, Brown DL, McCann M, Townsend JE, Leroy AJ (2008) Neonatal thyroid function after administration of IV iodinated contrast agent to 21 pregnant patients. AJR 191:268–271

    CrossRef  PubMed  Google Scholar 

  • Baerga-Varela Y, Zietlow SP, Bannon MP, Harmsen WS, Ilstrup DM (2000) Trauma in pregnancy. Mayo Clin Proc 75:1243–1248

    CrossRef  PubMed  CAS  Google Scholar 

  • Bankier AA, Tack D (2010) Dose reduction strategies for thoracic multidetector computed tomography: background, current issues, and recommendations. J Thorac Imaging 25:278–288

    CrossRef  PubMed  Google Scholar 

  • Berlin L (1996) Radiation exposure and the pregnant patient. AJR 167:1377–1379

    PubMed  CAS  Google Scholar 

  • Bona G, Zaffaroni M, Defilippi C, Gallina MR, Mostert M (1992) Effects of iopamidol on neonatal thyroid function. Eur J Radiol 14:22–25

    CrossRef  PubMed  CAS  Google Scholar 

  • Bourjeily G, Paidas M, Khalil H, Rosene-Montella K, Rodger M (2009) Pulmonary embolism in pregnancy. Lancet 375:500–512

    CrossRef  PubMed  Google Scholar 

  • Bourjeily G, Khalil H, Raker C et al (2011) Outcomes of negative multidetector computed tomography with pulmonary angiography in pregnant women suspected of pulmonary embolism. Lung 19(5):267–274

    Google Scholar 

  • Brenner DJ, Hall EJ (2007) Computed tomography—an increasing source of radiation exposure. N Engl J Med 357:2277–2284

    CrossRef  PubMed  CAS  Google Scholar 

  • Brent RL (2009) Saving lives and changing family histories: appropriate counseling of pregnant women and men and women of reproductive age, concerning the risk of diagnostic radiation exposures during and before pregnancy. Am J Obstet Gynecol 200:4–24

    CrossRef  PubMed  Google Scholar 

  • Brown MA, Sirlin CB, Farahmand N, Hoyt DB, Casola G (2005) Screening sonography in pregnant patients with blunt abdominal trauma. J Ultrasound Med 24:175–181, quiz 183–184

    PubMed  Google Scholar 

  • Chen MM, Coakley FV, Kaimal A, Laros RK Jr (2008) Guidelines for computed tomography and magnetic resonance imaging use during pregnancy and lactation. Obstet Gynecol 112:333–340

    CrossRef  PubMed  Google Scholar 

  • Cobben LP, Groot I, Haans L, Blickman JG, Puylaert J (2004) MRI for clinically suspected appendicitis during pregnancy. AJR 183:671–675

    PubMed  Google Scholar 

  • Cook JV, Kyriou J (2005) Radiation from CT and perfusion scanning in pregnancy. BMJ 331:350

    CrossRef  PubMed  Google Scholar 

  • Doshi SK, Negus IS, Oduko JM (2008) Fetal radiation dose from CT pulmonary angiography in late pregnancy: a phantom study. Br J Radiol 81:653–658

    CrossRef  PubMed  CAS  Google Scholar 

  • El-Khoury GY, Madsen MT, Blake ME, Yankowitz J (2003) A new pregnancy policy for a new era. AJR 181:335–340

    PubMed  Google Scholar 

  • Esposito TJ, Gens DR, Smith LG, Scorpio R, Buchman T (1991) Trauma during pregnancy. A review of 79 cases. Arch Surg 126:1073–1078

    CrossRef  PubMed  CAS  Google Scholar 

  • Evans HJ, Wollin TA (2001) The management of urinary calculi in pregnancy. Curr Opin Urol 11:379–384

    CrossRef  PubMed  CAS  Google Scholar 

  • Goldberg-Stein S, Liu B, Hahn PF, Lee SI (2011) Body CT during pregnancy: utilization trends, examination indications, and fetal radiation doses. AJR 196:146–151

    CrossRef  PubMed  Google Scholar 

  • Goldman SM, Wagner LK (1999) Radiologic ABCs of maternal and fetal survival after trauma: when minutes may count. Radiographics 19:1349–1357

    PubMed  CAS  Google Scholar 

  • Grossman NB (2004) Blunt trauma in pregnancy. Am Fam Physician 70:1303–1310

    PubMed  Google Scholar 

  • Groves AM, Yates SJ, Win T et al (2006) CT pulmonary angiography versus ventilation-perfusion scintigraphy in pregnancy: implications from a UK survey of doctors’ knowledge of radiation exposure. Radiology 240:765–770

    CrossRef  PubMed  Google Scholar 

  • Guttman R, Goldman RD, Koren G (2004) Appendicitis during pregnancy. Can Fam Physician 50:355–357

    PubMed  Google Scholar 

  • Halvorsen RA (2008) Which study when? Iodinated contrast-enhanced CT versus gadolinium-enhanced MR imaging. Radiology 249:9–15

    CrossRef  PubMed  Google Scholar 

  • Hartmann IJ, Wittenberg R, Schaefer-Prokop C (2010) Imaging of acute pulmonary embolism using multi-detector CT angiography: an update on imaging technique and interpretation. Eur J Radiol 74:40–49

    CrossRef  PubMed  Google Scholar 

  • Heyer CM, Mohr PS, Lemburg SP, Peters SA, Nicolas V (2007) Image quality and radiation exposure at pulmonary CT angiography with 100- or 120-kVp protocol: prospective randomized study. Radiology 245:577–583

    CrossRef  PubMed  Google Scholar 

  • Huda WSR (2009) Review of radiologic physics, 3rd edn. Lippinkott Wiliams & Wilkins, Philadelphia

    Google Scholar 

  • Hurwitz LM, Yoshizumi T, Reiman RE et al (2006a) Radiation dose to the fetus from body MDCT during early gestation. AJR 186:871–876

    CrossRef  Google Scholar 

  • Hurwitz LM, Yoshizumi TT, Reiman RE et al (2006b) Radiation dose to the female breast from 16-MDCT body protocols. AJR 186:1718–1722

    CrossRef  Google Scholar 

  • Hurwitz LM, Reiman RE, Yoshizumi TT et al (2007) Radiation dose from contemporary cardiothoracic multidetector CT protocols with an anthropomorphic female phantom: implications for cancer induction. Radiology 245:742–750

    CrossRef  PubMed  Google Scholar 

  • Hurwitz LM, Yoshizumi TT, Goodman PC et al (2009) Radiation dose savings for adult pulmonary embolus 64-MDCT using bismuth breast shields, lower peak kilovoltage, and automatic tube current modulation. AJR 192:244–253

    CrossRef  PubMed  Google Scholar 

  • Ito S (2000) Drug therapy for breast-feeding women. N Engl J Med 343:118–126

    CrossRef  PubMed  CAS  Google Scholar 

  • Jaffe TA, Yoshizumi TT, Toncheva GI, Nguyen G, Hurwitz LM, Nelson RC (2008) Early first-trimester fetal radiation dose estimation in 16-MDCT without and with automated tube current modulation. AJR 190:860–864

    CrossRef  PubMed  Google Scholar 

  • Jaffe TA, Yoshizumi TT, Toncheva G et al (2009a) Radiation dose for body CT protocols: variability of scanners at one institution. AJR 193:1141–1147

    CrossRef  PubMed  Google Scholar 

  • Jaffe TA, Neville AM, Anderson-Evans C et al (2009b) Early first trimester fetal dose estimation method in a multivendor study of 16- and 64-MDCT scanners and low-dose imaging protocols. AJR 193:1019–1024

    CrossRef  PubMed  Google Scholar 

  • Kallen JA, Coughlin BF, O’Loughlin MT, Stein B (2009) Reduced Z-axis coverage multidetector CT angiography for suspected acute pulmonary embolism could decrease dose and maintain diagnostic accuracy. Emerg Radiol 17:31–35

    CrossRef  PubMed  Google Scholar 

  • Katz DS, Venkataramanan N, Napel S, Sommer FG (2003) Can low-dose unenhanced multidetector CT be used for routine evaluation of suspected renal colic? AJR 180:313–315

    PubMed  Google Scholar 

  • King-IM JU, Freeman SJ, Boylan T, Cheow HK (2008) Quality of CT pulmonary angiography for suspected pulmonary embolus in pregnancy. Eur Radiol 18:2709–2715

    CrossRef  Google Scholar 

  • Lameris W, van Randen A, van Es HW et al (2009) Imaging strategies for detection of urgent conditions in patients with acute abdominal pain: diagnostic accuracy study. BMJ 338:b2431

    CrossRef  PubMed  Google Scholar 

  • Lazarus E, Mayo-Smith WW, Mainiero MB, Spencer PK (2007) CT in the evaluation of nontraumatic abdominal pain in pregnant women. Radiology 244:784–790

    CrossRef  PubMed  Google Scholar 

  • Lazarus E, Debenedectis C, North D, Spencer PK, Mayo-Smith WW (2009) Utilization of imaging in pregnant patients: 10-year review of 5270 examinations in 3285 patients–1997–2006. Radiology 251:517–524

    CrossRef  PubMed  Google Scholar 

  • Lechel U, Becker C, Langenfeld-Jager G, Brix G (2009) Dose reduction by automatic exposure control in multidetector computed tomography: comparison between measurement and calculation. Eur Radiol 19:1027–1034

    CrossRef  PubMed  CAS  Google Scholar 

  • Lee I, Chew FS (2009) Use of IV iodinated and gadolinium contrast media in the pregnant or lactating patient: self-assessment module. AJR 193:S70–S73

    CrossRef  PubMed  CAS  Google Scholar 

  • Leung AN, Bull TM, Jaeschke R et al (2011) An official American thoracic society/society of thoracic radiology clinical practice guideline: evaluation of suspected pulmonary embolism in pregnancy. Am J Respir Crit Care Med 184:1200–1208

    CrossRef  PubMed  Google Scholar 

  • Lim HK, Bae SH, Seo GS (1992) Diagnosis of acute appendicitis in pregnant women: value of sonography. AJR 159:539–542

    PubMed  CAS  Google Scholar 

  • Litmanovich D, Boiselle PM, Bankier AA, Kataoka ML, Pianykh O, Raptopoulos V (2009) Dose reduction in computed tomographic angiography of pregnant patients with suspected acute pulmonary embolism. J Comput Assist Tomogr 33:961–966

    CrossRef  PubMed  Google Scholar 

  • Litmanovich D, Tack D, Lin PJ, Boiselle PM, Raptopoulos V, Bankier AA (2011) Female breast, lung, and pelvic organ radiation from dose-reduced 64-MDCT thoracic examination protocols: a phantom study. AJR 197:929–934

    CrossRef  PubMed  Google Scholar 

  • Lowdermilk C, Gavant ML, Qaisi W, West OC, Goldman SM (1999) Screening helical CT for evaluation of blunt traumatic injury in the pregnant patient. Radiographics 19:S243–S255, discussion S256–S248

    PubMed  Google Scholar 

  • Maglinte DD, Gourtsoyiannis N, Rex D, Howard TJ, Kelvin FM (2003) Classification of small bowel Crohn’s subtypes based on multimodality imaging. Radiol Clin North Am 41:285–303

    CrossRef  PubMed  Google Scholar 

  • Martin JN Jr, Ridgway LE 3rd, Connors JJ, Sessums JK, Martin RW, Morrison JC (1990) Angiographic arterial embolization and computed tomography-directed drainage for the management of hemorrhage and infection with abdominal pregnancy. Obstet Gynecol 76:941–945

    PubMed  Google Scholar 

  • Mayo JR, Aldrich J, Muller NL (2003) Radiation exposure at chest CT: a statement of the Fleischner Society. Radiology 228:15–21

    CrossRef  PubMed  Google Scholar 

  • McAleer SJ, Loughlin KR (2004) Nephrolithiasis and pregnancy. Curr Opin Urol 14:123–127

    CrossRef  PubMed  Google Scholar 

  • McCollough CH, Schueler BA, Atwell TD et al (2007) Radiation exposure and pregnancy: when should we be concerned? Radiographics 27:909–917, discussion 917–918

    CrossRef  PubMed  Google Scholar 

  • Pahade JK, Litmanovich D, Pedrosa I, Romero J, Bankier AA, Boiselle PM (2009) Quality initiatives: imaging pregnant patients with suspected pulmonary embolism: what the radiologist needs to know. Radiographics 29:639–654

    CrossRef  PubMed  Google Scholar 

  • Parker MS, Hui FK, Camacho MA, Chung JK, Broga DW, Sethi NN (2005) Female breast radiation exposure during CT pulmonary angiography. AJR 185:1228–1233

    CrossRef  PubMed  Google Scholar 

  • Parulkar BG, Hopkins TB, Wollin MR, Howard PJ Jr, Lal A (1998) Renal colic during pregnancy: a case for conservative treatment. J Urol 159:365–368

    CrossRef  PubMed  CAS  Google Scholar 

  • Patel SJ, Reede DL, Katz DS, Subramaniam R, Amorosa JK (2007) Imaging the pregnant patient for nonobstetric conditions: algorithms and radiation dose considerations. Radiographics 27:1705–1722

    CrossRef  PubMed  Google Scholar 

  • Pedrosa I, Levine D, Eyvazzadeh AD, Siewert B, Ngo L, Rofsky NM (2006) MR imaging evaluation of acute appendicitis in pregnancy. Radiology 238:891–899

    CrossRef  PubMed  Google Scholar 

  • Pedrosa I, Zeikus EA, Levine D, Rofsky NM (2007) MR imaging of acute right lower quadrant pain in pregnant and nonpregnant patients. Radiographics 27:721–743, discussion 743–753

    CrossRef  PubMed  Google Scholar 

  • Peet DJ, Pryor MD (1999) Evaluation of a MOSFET radiation sensor for the measurement of entrance surface dose in diagnostic radiology. Br J Radiol 72:562–568

    PubMed  CAS  Google Scholar 

  • Protection ICoR (2000) Pregnancy and medical radiation. Ann ICRP 30:iii–viii, 1–43

    Google Scholar 

  • Protection ICoR (2003) Biological effects after prenatal irradiation (embryo and fetus). ICRP publication no 90, New York, pp 7–8

    Google Scholar 

  • Ratnapalan S, Bona N, Chandra K, Koren G (2004) Physicians’ perceptions of teratogenic risk associated with radiography and CT during early pregnancy. AJR 182:1107–1109

    PubMed  Google Scholar 

  • Revel MP, Cohen S, Sanchez O et al (2011) Pulmonary embolism during pregnancy: diagnosis with lung scintigraphy or CT angiography? Radiology 258:590–598

    CrossRef  PubMed  Google Scholar 

  • Rhea JT, Garza DH, Novelline RA (2004) Controversies in emergency radiology. CT versus ultrasound in the evaluation of blunt abdominal trauma. Emerg Radiol 10:289–295

    PubMed  Google Scholar 

  • Ridge CA, McDermott S, Freyne BJ, Brennan DJ, Collins CD, Skehan SJ (2009) Pulmonary embolism in pregnancy: comparison of pulmonary CT angiography and lung scintigraphy. AJR 193:1223–1227

    CrossRef  PubMed  Google Scholar 

  • Ridge CA, Mhuircheartaigh JN, Dodd JD, Skehan SJ (2011) Pulmonary CT angiography protocol adapted to the hemodynamic effects of pregnancy. AJR 197:1058–1063

    CrossRef  PubMed  Google Scholar 

  • Ripolles T, Errando J, Agramunt M, Martinez MJ (2004) Ureteral colic: US versus CT. Abdom Imaging 29:263–266

    CrossRef  PubMed  CAS  Google Scholar 

  • Roy C, Saussine C, LeBras Y et al (1996) Assessment of painful ureterohydronephrosis during pregnancy by MR urography. Eur Radiol 6:334–338

    PubMed  CAS  Google Scholar 

  • Schaefer-Prokop C, Prokop M (2008) CTPA for the diagnosis of acute pulmonary embolism during pregnancy. Eur Radiol 18:2705–2708

    CrossRef  PubMed  Google Scholar 

  • Schmidt B (2001) Dose calculations for computed tomography. Reports from the Institute of Medical Physics. Shaker, Aachen

    Google Scholar 

  • Schmidt B, Kalender W (2002) A fast voxel-based Monte Carlo method for scanner-abd patient-specific dose calculations in computed tomography. In: Guerra AD (ed) Physica medica: European journal of medical physics. Instituti Editoriali e Politgrafici Internzionali, Pisa, pp 43–53

    Google Scholar 

  • Schueller-Weidekamm C, Schaefer-Prokop CM, Weber M, Herold CJ, Prokop M (2006) CT angiography of pulmonary arteries to detect pulmonary embolism: improvement of vascular enhancement with low kilovoltage settings. Radiology 241:899–907

    CrossRef  PubMed  Google Scholar 

  • Sigal-Cinqualbre AB, Hennequin R, Abada HT, Chen X, Paul JF (2004) Low-kilovoltage multi-detector row chest CT in adults: feasibility and effect on image quality and iodine dose. Radiology 231:169–174

    CrossRef  PubMed  Google Scholar 

  • Smith RC, Rosenfield AT, Choe KA et al (1995) Acute flank pain: comparison of non-contrast-enhanced CT and intravenous urography. Radiology 194:789–794

    PubMed  CAS  Google Scholar 

  • Smith-Bindman R, Lipson J, Marcus R et al (2009) Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. Arch Intern Med 169:2078–2086

    CrossRef  PubMed  Google Scholar 

  • Steffer C, Protection ICoR (2007) The ICRP 2007 recommendations. Radiat Prot Dosimetry 127:2–7

    Google Scholar 

  • Stothers L, Lee LM (1992) Renal colic in pregnancy. J Urol 148:1383–1387

    PubMed  CAS  Google Scholar 

  • Tack D, Gevenois PA (2009) Body MDCT at 140 kV. AJR 192:W139–W140, author reply W141–W135

    Google Scholar 

  • Tack D, De Maertelaer V, Petit W et al (2005) Multi-detector row CT pulmonary angiography: comparison of standard-dose and simulated low-dose techniques. Radiology 236:318–325

    CrossRef  PubMed  Google Scholar 

  • Toglia MR, Weg JG (1996) Venous thromboembolism during pregnancy. N Engl J Med 335:108–114

    CrossRef  PubMed  CAS  Google Scholar 

  • Tracey M, Fletcher HS (2000) Appendicitis in pregnancy. Am Surg 66:555–559, discussion 559–560

    PubMed  CAS  Google Scholar 

  • Vollmar SV, Kalender WA (2008) Reduction of dose to the female breast in thoracic CT: a comparison of standard-protocol, bismuth-shielded, partial and tube-current-modulated CT examinations. Eur Radiol 18:1674–1682

    CrossRef  PubMed  Google Scholar 

  • Vu L, Ambrose D, Vos P, Tiwari P, Rosengarten M, Wiseman S (2009) Evaluation of MRI for the diagnosis of appendicitis during pregnancy when ultrasound is inconclusive. J Surg Res 156:145–149

    CrossRef  PubMed  Google Scholar 

  • Wagner LK, Lester RG, Saldana LR (1997) Exposure of the pregnant patient to diagnostic radiation: a guide to medical management. Medical Physics, Madison

    Google Scholar 

  • Webb JA, Thomsen HS, Morcos SK (2005) The use of iodinated and gadolinium contrast media during pregnancy and lactation. Eur Radiol 15:1234–1240

    CrossRef  PubMed  Google Scholar 

  • Wieseler KM, Bhargava P, Kanal KM, Vaidya S, Stewart BK, Dighe MK (2010) Imaging in pregnant patients: examination appropriateness. Radiographics 30:1215–1229, discussion 1230–1213

    CrossRef  PubMed  Google Scholar 

  • Winer-Muram HT, Boone JM, Brown HL, Jennings SG, Mabie WC, Lombardo GT (2002) Pulmonary embolism in pregnant patients: fetal radiation dose with helical CT. Radiology 224:487–492

    CrossRef  PubMed  Google Scholar 

  • Yousefzadeh DK, Ward MB, Reft C (2006) Internal barium shielding to minimize fetal irradiation in spiral chest CT: a phantom simulation experiment. Radiology 239:751–758

    CrossRef  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to D. E. Litmanovich .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Litmanovich, D.E., Bankier, A.A. (2012). CT Scanning in Pregnancy. In: Tack, D., Kalra, M., Gevenois, P. (eds) Radiation Dose from Multidetector CT. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_521

Download citation

  • DOI: https://doi.org/10.1007/174_2011_521

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-24534-3

  • Online ISBN: 978-3-642-24535-0

  • eBook Packages: MedicineMedicine (R0)