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Liver Metastasis

  • Michelle Stinauer
  • Rachelle Lanciano
  • Tracey E. Schefter
  • Brian Kavanagh
  • Julie A. Carlson
  • Alan W. Katz
Part of the Medical Radiology book series (MEDRAD)

Abstract

With its dual portal and arterial blood supply, the liver is a common site for metastatic disease. Traditionally the liver has been viewed as a difficult organ to irradiate due to both normal tissue constraints as well as organ motion. New devices for patient immobilization, better imaging techniques, and advanced treatment delivery methods such as stereotactic body radiation therapy (SBRT), have made radiation therapy a viable therapeutic option for liver metastases. Oligometastatic disease from several solid primary cancers is now considered a potentially curable state. As such, ablative therapies such as SBRT offer a non-invasive alternative to surgery and radiofrequency ablation (RFA). This chapter will review the technical and clinical aspects of SBRT for liver metastases.

Keywords

Liver Metastasis Stereotactic Body Radiation Therapy Gross Tumor Volume Local Control Rate Isodose Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Definitions of Abbreviations Used

SBRT

Stereotactic body radiation therapy

RFA

Radiofrequency ablation

PTV

Planning target volume

GTV

Gross tumor volume

CT

Computed tomography

PET

Positron emission tomography

CTV

Clinical tumor volume

ITV

Internal target volume

MRI

Magnetic resonance imaging

DDR

Digitally reconstructed radiograph

BED

Biological equivalent dose

TACE

Transarterial chemo-embolization

RILD

Radiation induced liver disease

HCC

Hepatocellular carcinoma

VOD

Veno-occlusive disease

QUANTEC

Quantitative analysis of normal tissue effect in the clinic

Notes

Conflict of Interest

There are no potential conflicts of interest among the authors and this manuscript. There are no financial or non-financial competing interests. This manuscript has been seen, read, and agreed upon in its content by all designated authors. This manuscript has not been submitted or published elsewhere.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Michelle Stinauer
    • 1
  • Rachelle Lanciano
    • 2
  • Tracey E. Schefter
    • 1
  • Brian Kavanagh
    • 1
  • Julie A. Carlson
    • 1
  • Alan W. Katz
    • 3
  1. 1.Department of Radiation OncologyUniversity of Colorado DenverAuroraUSA
  2. 2.Department of Radiation OncologyDelaware County Memorial HospitalDrexel HillUSA
  3. 3.Department of Radiation OncologyUniversity of Rochester Medical CenterRochesterUSA

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