Liver Metastasis

  • Michelle Stinauer
  • Rachelle Lanciano
  • Tracey E. Schefter
  • Brian Kavanagh
  • Julie A. Carlson
  • Alan W. Katz
Part of the Medical Radiology book series (MEDRAD)


With its dual portal and arterial blood supply, the liver is a common site for metastatic disease. Traditionally the liver has been viewed as a difficult organ to irradiate due to both normal tissue constraints as well as organ motion. New devices for patient immobilization, better imaging techniques, and advanced treatment delivery methods such as stereotactic body radiation therapy (SBRT), have made radiation therapy a viable therapeutic option for liver metastases. Oligometastatic disease from several solid primary cancers is now considered a potentially curable state. As such, ablative therapies such as SBRT offer a non-invasive alternative to surgery and radiofrequency ablation (RFA). This chapter will review the technical and clinical aspects of SBRT for liver metastases.


Liver Metastasis Stereotactic Body Radiation Therapy Gross Tumor Volume Local Control Rate Isodose Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Definitions of Abbreviations Used


Stereotactic body radiation therapy


Radiofrequency ablation


Planning target volume


Gross tumor volume


Computed tomography


Positron emission tomography


Clinical tumor volume


Internal target volume


Magnetic resonance imaging


Digitally reconstructed radiograph


Biological equivalent dose


Transarterial chemo-embolization


Radiation induced liver disease


Hepatocellular carcinoma


Veno-occlusive disease


Quantitative analysis of normal tissue effect in the clinic


Conflict of Interest

There are no potential conflicts of interest among the authors and this manuscript. There are no financial or non-financial competing interests. This manuscript has been seen, read, and agreed upon in its content by all designated authors. This manuscript has not been submitted or published elsewhere.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Michelle Stinauer
    • 1
  • Rachelle Lanciano
    • 2
  • Tracey E. Schefter
    • 1
  • Brian Kavanagh
    • 1
  • Julie A. Carlson
    • 1
  • Alan W. Katz
    • 3
  1. 1.Department of Radiation OncologyUniversity of Colorado DenverAuroraUSA
  2. 2.Department of Radiation OncologyDelaware County Memorial HospitalDrexel HillUSA
  3. 3.Department of Radiation OncologyUniversity of Rochester Medical CenterRochesterUSA

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