Lung Metastasis

  • Neha Amin
  • Tracey E. Schefter
  • Paul Okunieff
  • Brian Kavanagh
  • Michael T. Milano
Part of the Medical Radiology book series (MEDRAD)


Lung metastases are a common source of morbidity and mortality. Despite significant improvements in outcome with systemic therapy in recent years, it is infrequent that lung metastases or sites of macrometastatic disease are controlled permanently. Furthermore, most lung metastases are not amenable to what is considered the gold standard locally ablative therapy, surgical resection and consequently there has been a surge in interest in non-surgical ablative therapies such as stereotactic body radiation therapy (SBRT). Much of the support for SBRT for lung metastases has been extrapolated from the non-small cell lung cancer (NSCLC) experience, where SBRT has been shown to be safe and effective. In contrast to lung cancer, most patients with lung metastases have favorable lung function making treatment of multiple synchronous or metachronous metastases potentially safer and better tolerated. This chapter will provide an overview of the technical and clinical aspects of SBRT for lung metastases. Readers should also refer to the NSCLC chapter as there is considerable overlap with SBRT for lung metastases.


Lung Metastasis Stereotactic Body Radiation Therapy Gross Tumor Volume Radiation Therapy Oncology Group Biologic Effective Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Stereotactic body radiation therapy


Non-small cell lung cancer


Organ at risk


Radiation Therapy Oncology Group


Japan Clinical Oncology Group


Planning target volume


Abdominal compression plates




Active breathing control


Deep inspiration breath-hold


Four-dimensional computed tomography


Internal target volume


Maximal intensity projection


Gross tumor volume


Clinical tumor volume


Monte Carlo


Pencil beam


Collapsed cone


Biological equivalent dose


Linear quadratic


Universal survival curve




Image-guided radiation therapy


On-board imager


Megavoltage computed tomography


Digitally reconstructed radiograph


Electronic portal imaging device


Breathing synchronized delivery


Real-time tumor tracking


Real-time position management


Mean lung dose


Memorial Sloan-Kettering Cancer Center


M. D. Anderson Cancer Center


Quantitative analysis of normal tissue effect in the clinic


Conflict of Interest

There are no potential conflicts of interest among the authors and this manuscript. There are no financial or non-financial competing interests. This manuscript has been seen, read, and agreed upon in its content by all designated authors. This manuscript has not been submitted or published elsewhere.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Neha Amin
    • 1
  • Tracey E. Schefter
    • 1
  • Paul Okunieff
    • 2
  • Brian Kavanagh
    • 1
  • Michael T. Milano
    • 3
  1. 1.Department of Radiation OncologyUniversity of Colorado DenverAuroraUSA
  2. 2.Department of Radiation OncologyUniversity of FloridaGainesvilleUSA
  3. 3.Department of Radiation OncologyUniversity of RochesterRochesterUSA

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