Spinal Metastasis

  • Simon S. Lo
  • Andrew E. Sloan
  • Mitchell Machtay
  • Bin S. Teh
  • Arjun Sahgal
  • Samuel T. Chao
  • Eric L. Chang
Part of the Medical Radiology book series (MEDRAD)


Spinal metastasis can cause pain and neurologic dysfunction as a result of compression of spinal cord, cauda equina, or nerve roots. In patients with spinal cord compression, surgical resection with postoperative radiotherapy is offered. Otherwise, radiotherapy is often given alone for the palliation of these symptoms. However, the amount of radiation that can be given to the spine is limited by the spinal cord tolerance, especially in cases of re-irradiation for recurrent disease. Stereotactic body radiation therapy (SBRT) or stereotactic ablative radiation therapy (SABR) can potentially provide a favorable therapeutic window by allowing the delivery of an ablative dose of radiation to spinal metastases while limiting the spinal cord dose to within the constraints. In the recent years, abundant data on the use of SBRT/SABR for spinal metastasis have emerged in the literature. This chapter will provide an overview of the technical and clinical aspects of SBRT/SABR for spinal metastasis.


Intensity Modulate Radiation Therapy Clinical Target Volume Spinal Cord Compression Stereotactic Body Radiation Therapy Gross Tumor Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Simon S. Lo
    • 1
  • Andrew E. Sloan
    • 2
  • Mitchell Machtay
    • 1
  • Bin S. Teh
    • 3
  • Arjun Sahgal
    • 4
  • Samuel T. Chao
    • 5
  • Eric L. Chang
    • 6
  1. 1.Department of Radiation OncologyUniversity Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve UniversityClevelandUSA
  2. 2.Brain Tumor and Neuro-Oncology Center, University Hospitals Seidman Cancer Center Case Western Reserve UniversityClevelandUSA
  3. 3.Department of Radiation Oncology, Weill Cornell College of MedicineThe Methodist Hospital Cancer CenterHoustonUSA
  4. 4.Department of Radiation Oncology, Princess Margaret Hospital and Toronto Sunnybrook HospitalUniversity of TorontoTorontoCanada
  5. 5.Department of Radiation OncologyCleveland Clinic FoundationClevelandUSA
  6. 6.Department of Radiation OncologyKeck School of Medicine and Norris Cancer Hospital, University of Southern CaliforniaLos AngelesUSA

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