Imaging Techniques

  • Robert Hermans
  • Frederik De Keyzer
  • Vincent Vandecaveye
  • Laurens Carp
Part of the Medical Radiology book series (MEDRAD)


Various imaging techniques are used to investigate the presence and extent of head and neck neoplasms, including ultrasound, computed tomography, magnetic resonance imaging and nuclear imaging techniques. To obtain the most optimal results, close attention should be paid to a correct technical execution of the imaging study. This chapter provides information on the relative advantages and disadvantages of each of the available imaging techniques, as well as on patient preparation, contrast agent or tracer injection, data acquisition, and image reconstruction, reformatting and display. The possible value of some newer imaging techniques, such as diffusion-weighted MRI and dynamic contrast-enhanced MRI is also reviewed.


Positron Emission Tomography Susceptibility Artifact Salivary Gland Cancer Extravascular Extracellular Space Signal Intensity Curve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407:249–257PubMedCrossRefGoogle Scholar
  2. Curtin HD, Ishwaran H, Mancuso AA et al (1998) Comparison of CT and MR imaging in staging of neck metastases. Radiology 207:123–130PubMedGoogle Scholar
  3. De Foer B, Vercruysse JP, Bernaerts A et al (2008) Detection of postoperative residual cholesteatoma with non-echo-planar diffusion-weighted magnetic resonance imaging. Otol Neurotol 29:513–517PubMedCrossRefGoogle Scholar
  4. Goshen E, Davidson T, Yahalom R et al (2006) PET/CT in the evaluation of patients with squamous cell cancer of the head and neck. Int J Oral Maxillofac Surg 35:332–336PubMedCrossRefGoogle Scholar
  5. Henrot P, Blum A, Toussaint B, Troufleau P, Stines J, Roland J (2003) Dynamic maneuvers in local staging of head and neck malignancies with current imaging techniques: principles and clinical applications. Radiographics 23:1201–1213PubMedCrossRefGoogle Scholar
  6. Higashi K, Clavo AC, Wahl RL (1993) In vitro assessment of 2-fluoro-2-deoxy-d-glucose, l-methionine and thymidine as agents to monitor the early response of a human adenocarcinoma cell line to radiotherapy. J Nucl Med 34:773–779PubMedGoogle Scholar
  7. Jones T (1996) The imaging science of positron emission tomography. Eur J Nucl Med 23:807–813PubMedCrossRefGoogle Scholar
  8. Keberle M, Tschammler A, Hahn D (2002) Single-bolus technique for spiral CT of laryngopharyngeal squamous cell carcinoma: comparison of different contrast material volumes, flow rates, and start delays. Radiology 224:171–176PubMedCrossRefGoogle Scholar
  9. Kubota R, Yamada S, Kubota K et al (1992) Intratumoural distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med 33:1972–1980PubMedGoogle Scholar
  10. Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497–505PubMedGoogle Scholar
  11. Lell MM, Greess H, Hothorn T, Janka R, Bautz WA, Baum U (2004) Multiplanar functional imaging of the larynx and hypopharynx with multislice spiral CT. Eur Radiol 14:2198–2205PubMedCrossRefGoogle Scholar
  12. Magnano M, Bongioannini G, Cirillo S et al (2005) Virtual endoscopy of laryngeal carcinoma: is it useful? Otolaryngol Head Neck Surg 13:776–782CrossRefGoogle Scholar
  13. McCabe KJ, Rubinstein D (2005) Advances in head and neck imaging. Otolaryngol Clin North Am 38:307−319 viiGoogle Scholar
  14. Padhani AR (2003) MRI for assessing antivascular cancer treatments. Br J Radiol 76:S60–S80PubMedCrossRefGoogle Scholar
  15. Pauwels E, McCready VR, Stoot JH et al (1998) The mechanism of accumulation of tumour-localising radiopharmaceuticals. Eur J Nucl Med 25:277–305PubMedCrossRefGoogle Scholar
  16. Port RE, Knopp MV, Brix G (2001) Dynamic contrast-enhanced MRI using Gd-DTPA: interindividual variability of the arterial input function and consequences for the assessment of kinetics in tumors. Magn Reson Med 45:1030–1038PubMedCrossRefGoogle Scholar
  17. Robert YH, Chevalier D, Rocourt NL et al (1993) Dynamic maneuver acquired with spiral CT in laryngeal disease. Radiology 189:298–299Google Scholar
  18. Rodrigues RS, Bozza FA, Christian PE et al (2009) Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck. J Nucl Med 50:1205–1213PubMedCrossRefGoogle Scholar
  19. Schöder H, Fury M, Lee N, Kraus D (2009) PET monitoring of therapy response in head and neck squamous cell carcinoma. J Nucl Med 50 Suppl 1:74S−88SGoogle Scholar
  20. Sigal R, Vogl T, Casselman J et al (2002) Lymph node metastases from head and neck squamous cell carcinoma: MR imaging with ultrasmall superparamagnetic iron oxide particles (Sinerem MR)––results of a phase-III multicenter clinical trial. Eur Radiol 12:1104–1113PubMedCrossRefGoogle Scholar
  21. Silverman PM, Zeiberg AS, Sessions RB, Troost TR, Zeman RK (1995) Three-dimensional imaging of the hypopharynx and larynx by means of helical (spiral) computed tomography. Comparison of radiological and otolaryngological evaluation. Ann Otol Rhinol Laryngol 104:425–431PubMedGoogle Scholar
  22. Takahara T, Imai Y, Yamashita T, Yasuda S, Nasu S, Van Cauteren M (2004) Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med 22:275–282PubMedGoogle Scholar
  23. Takes RP, Knegt P, Manni JJ et al (1996) Regional metastasis in head and neck squamous cell carcinoma: revised value of US with US-guided FNAB. Radiology 198:819–823PubMedGoogle Scholar
  24. Takes RP, Righi P, Meeuwis CA et al (1998) The value of ultrasound with ultrasound-guided fine-needle aspiration biopsy compared to computed tomography in the detection of regional metastases in the clinically negative neck. Int J Radiat Oncol Biol Phys 40:1027–1032PubMedCrossRefGoogle Scholar
  25. Thoeny HC, De Keyzer F, Vandecaveye V et al (2005) Effect of vascular targeting agent in rat tumor model: dynamic contrast-enhanced versus diffusion-weighted MR imaging. Radiology 237:492–499PubMedCrossRefGoogle Scholar
  26. Tofts PS, Kermode AG (1991) Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn Reson Med 17:357–367PubMedCrossRefGoogle Scholar
  27. Townsend D (2008) Dual-modality imaging: combining anatomy, function. J Nucl Med 49:938–955PubMedCrossRefGoogle Scholar
  28. van den Brekel MW, Castelijns JA, Stel HV et al (1991) Occult metastatic neck disease: detection with US and US-guided fine-needle aspiration cytology. Radiology 180:457–461PubMedGoogle Scholar
  29. Vandecaveye V, De Keyzer F, Dirix P et al (2010) Applications of diffusion-weighted magnetic resonance imaging in head and neck squamous cell carcinoma. Neuroradiology 52:773–784PubMedCrossRefGoogle Scholar
  30. Vogel WV, Wensing BM, van Dalen JA et al (2005) Optimised PET reconstruction of the head and neck area: improved diagnostic accuracy. Eur J Nucl Med Mol Imaging. 32:1276–1282PubMedCrossRefGoogle Scholar
  31. Warburg O (1956) On the origin of cancer cells. Science 123:309–314PubMedCrossRefGoogle Scholar
  32. Wirth S, Meindl T, Treitl M, Pfeifer KJ, Reiser M (2006) Comparison of different patient positioning strategies to minimize shoulder girdle artifacts in head and neck CT. Eur Radiol 16:1757–1762PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Robert Hermans
    • 1
  • Frederik De Keyzer
    • 1
  • Vincent Vandecaveye
    • 1
  • Laurens Carp
    • 2
  1. 1.Department of RadiologyUniversity Hospitals LeuvenLeuvenBelgium
  2. 2.Service of Nuclear MedicineUniversity Hospital AntwerpEdegemBelgium

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