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Heart Failure and Heart Transplantation

  • S. Dymarkowski
  • J. Bogaert
Part of the Medical Radiology book series (MEDRAD)

Abstract

Heart failure (HF) may be the result of all forms of cardiac disease. Therefore, the development of accurate diagnostic tools for proper selection of therapeutic options is necessary to achieve good response rates in revascularization or resynchronization therapies. The same statement is true for implantation of cardioverter/defibrillators (ICD). Quantification of LV and RV function by MR imaging in patients with HF is quite routinely performed as a surrogate biomarker of baseline status or as a treatment follow-up tool, and can be considered as the standard of reference for quantification of LV and RV volumes and function. Further in this chapter, the role of cardiac MR imaging in resynchronization therapy (CRT) will be discussed, related to imaging of and quantification of the amount of scar tissue and the spatial relation of the myocardial scar to the site of LV pacing, since these are considered important parameters for CRT response. Finally, we will show that a comprehensive MRI exam may be used to noninvasively detect transplant vasculopathy and transplant-related complications.

Keywords

Cardiac Resynchronization Therapy Heart Failure Patient Fabry Disease Constrictive Pericarditis Myocardial Scar 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Abdel-Aty H, Boye P, Zagrosek A et al (2005) Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches. J Am Coll Cardiol 45:1815–1822PubMedCrossRefGoogle Scholar
  2. Adelstein EC, Saba S (2007) Scar burden by myocardial perfusion imaging predicts echocardiographic response to cardiac resynchronization therapy in ischemic cardiomyopathy. Am Heart J 153:105–112PubMedCrossRefGoogle Scholar
  3. Almenar L, Iguala B, Martínez-Dolza L et al (2003) Utility of cardiac magnetic resonance imaging for the diagnosis of heart transplant rejection. Transpl Proc 35:1962–1964CrossRefGoogle Scholar
  4. Anderson LJ, Holden S, Davis B et al (2001) Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 22:2171–2179PubMedCrossRefGoogle Scholar
  5. Barkhausen J, Ruehm SG, Goyen M et al (2001) MR evaluation of ventricular function: true fast imaging with steady-state precession versus fast low-angle shot cine MR imaging: feasibility study. Radiology 219:264–269PubMedGoogle Scholar
  6. Beer M, Stamm H, Machann W et al (2010) Free breathing cardiac real-time cine MR without ECG triggering. Int J Cardiol 145(2):380–382PubMedCrossRefGoogle Scholar
  7. Bengel FM, Ueberfuhr P, Schiepel N et al (2001) Effect of sympathetic reinnervation on cardiac performance after heart transplantation. N Engl J Med 345:731–738PubMedCrossRefGoogle Scholar
  8. Billingham ME (1982) Diagnosis of cardiac rejection by endomyocardial biopsy. Heart Transpl 1:25–30Google Scholar
  9. Birnie DH, Tang AS (2006) The problem of nonresponse to cardiac resynchronization therapy. Curr Opin Cardiol 21:20–26PubMedCrossRefGoogle Scholar
  10. Bleeker GB, Kaandorp TA, Lamb HJ et al (2006) Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy. Circulation 113:969–976PubMedCrossRefGoogle Scholar
  11. Bogaert J, Bosmans H, Rademakers FE et al (1995) Left ventricular quantification with breath-hold MR imaging: comparison with echocardiography. MAGMA 3:5–12PubMedCrossRefGoogle Scholar
  12. Caus T, Kober F, Marin P et al (2006) Non-invasive diagnostic of cardiac allograft vasculopathy by 31P magnetic resonance chemical shift imaging. Eur J Cardiothorac Surg 29(1):45–49PubMedCrossRefGoogle Scholar
  13. Caves PK, Stinson EB, Graham AF et al (1973) Percutaneous transvenous endomyocardial biopsy. JAMA 225:288–291PubMedCrossRefGoogle Scholar
  14. Chung ES, Leon AR, Tavazzi L et al (2008) Results of the predictors of response to CRT (PROSPECT) trial. Circulation 117:2608–2616PubMedCrossRefGoogle Scholar
  15. Cleland JG, Daubert JC, Erdmann E et al (2005) The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 352:1539–1549PubMedCrossRefGoogle Scholar
  16. Cotts WG, Oren RM (1997) Function of the transplanted heart: unique physiology and therapeutic implications. Am J Med Sci 314:164–172PubMedCrossRefGoogle Scholar
  17. Delgado V, Bax JJ (2011) Assessment of Systolic Dyssynchrony for Cardiac Resynchronization Therapy Is Clinically Useful. Circulation 123(6):640–655PubMedCrossRefGoogle Scholar
  18. Doornbos J, Verwey H, Essed CE, Balk AH, de Roos A (1990) MR imaging in assessment of cardiac transplant rejection in humans. J Comput Assist Tomogr 14(1):77–81PubMedCrossRefGoogle Scholar
  19. Gabriel RS, Bakshi TK, Scott AG et al (2007) Reliability of echocardiographic indices of dyssynchrony. Echocardiography 24:40–46PubMedCrossRefGoogle Scholar
  20. Gassis SA, Delurgio DB, Leon AR (2006) Progress in cardiovascular disease: Technical considerations in cardiac resynchronization therapy. Prog Cardiovasc Dis 48:239–255PubMedCrossRefGoogle Scholar
  21. He T, Gatehouse PD, Kirk P et al (2007) Black-blood T2* technique for myocardial iron measurement in thalassemia. J Magn Reson Imaging 25:1205–1209PubMedCrossRefGoogle Scholar
  22. Hudsmith LE, Petersen SE, Tyler DJ et al (2006) Determination of cardiac volumes and mass with FLASH and SSFP cine sequences at 1.5 vs. 3 Tesla: a validation study. J Magn Reson Imaging 24(2):312–318PubMedCrossRefGoogle Scholar
  23. Johansson L, Johnsson C, Penno E, Björnerud A, Ahlström H (2002) Acute cardiac transplant rejection: detection and grading with MR imaging with a blood pool contrast agent—experimental study in the rat. Radiology 225(1):97–103PubMedCrossRefGoogle Scholar
  24. Kirk P, Roughton M, Porter JB et al (2009) Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation 120:1961–1968PubMedCrossRefGoogle Scholar
  25. Kurland RJ, West J, Kelley S et al (1989) Magnetic resonance imaging to detect heart transplant rejection: sensitivity and specificity. Transpl Proc 21:2537–2543Google Scholar
  26. Lardo AC, Abraham TP, Kass DA (2005) Magnetic resonance imaging assessment of ventricular dyssynchrony: current and emerging concepts. J Am Coll Cardiol 46:2223–2228PubMedCrossRefGoogle Scholar
  27. Maceira AM, Joshi J, Prasad SK et al (2005) Cardiovascular magnetic resonance in cardiac amyloidosis. Circulation 111:186–193PubMedCrossRefGoogle Scholar
  28. Mahrholdt H, Wagner A, Judd RM et al (2005) Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies. Eur Heart J 26:1461–1474PubMedCrossRefGoogle Scholar
  29. Marie PY, Angioi M, Carteaux JP et al (2001) Detection and prediction of acute heart transplant rejection with the myocardial T2 determination provided by a black-blood magnetic resonance imaging sequence. J Am Coll Cardiol 37:825–831PubMedCrossRefGoogle Scholar
  30. Marsan NA, Westenberg JJ, Ypenburg C et al (2009) Magnetic resonance imaging and response to cardiac resynchronization therapy: relative merits of left ventricular dyssynchrony and scar tissue. Eur Heart J 30:2360–2367PubMedCrossRefGoogle Scholar
  31. Marwick TH (2010) Echocardiography in the era of multimodality imaging. Heart Lung Circ 19(3):175–184PubMedCrossRefGoogle Scholar
  32. McMurray JJ, Pfeffer MA (2005) Heart failure. Lancet 365(9474):1877–1889PubMedCrossRefGoogle Scholar
  33. Mischi M, Van Den Bosch HM, Jansen AM et al (2008) Quantification of regional left ventricular dyssynchrony by magnetic resonance imaging. IEEE Trans Biomed Eng 55:985–995PubMedCrossRefGoogle Scholar
  34. Mollet NR, Dymarkowski S, Volders W et al (2002) Visualization of ventricular thrombi with contrast-enhanced magnetic resonance imaging in patients with ischemic heart disease. Circulation 106:2873–2876PubMedCrossRefGoogle Scholar
  35. Moon JC, Sachdev B, Elkington AG et al (2003a) Gadolinium enhanced cardiovascular magnetic resonance in Anderson-Fabry disease. Evidence for a disease specific abnormality of the myocardial interstitium. Eur Heart J 24:2151–2155PubMedCrossRefGoogle Scholar
  36. Moon JC, McKenna WJ, McCrohon JA et al (2003b) Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnetic resonance. J Am Coll Cardiol 41:1561–1567PubMedCrossRefGoogle Scholar
  37. Mousseaux E, Farge D, Guillemain R et al (1993) Assessing human cardiac allograft rejection using MRI with Gd-DOTA. J Comput Assist Tomogr 17:237–244PubMedCrossRefGoogle Scholar
  38. Muehling OM, Wilke NM, Panse P et al (2003) Reduced myocardial perfusion reserve and transmural perfusion gradient in heart transplant arteriopathy assessed by magnetic resonance imaging. J Am Coll Cardiol 42:1054–1060PubMedCrossRefGoogle Scholar
  39. Nishimura T, Sada M, Sasaki H et al (1987) Cardiac transplantation in dogs: evaluation with gated MRI and Gd-DTPA contrast enhancement. Heart Vessels 3:141–145PubMedCrossRefGoogle Scholar
  40. Nishimura T, Sada M, Sasaki H et al (1988) Assessment of severity of cardiac rejection in heterotopic heart transplantation using indium-111 antimyosin and magnetic resonance imaging. Cardiovasc Res 22:108–112PubMedCrossRefGoogle Scholar
  41. Ordas S, Frangi A (2005) Automatic quantitative analysis of myocardial wall motion and thickening from long-and short-axis cine MRI studies. Conf Proc IEEE Eng Med Biol Soc 7:7028–7031PubMedGoogle Scholar
  42. Osman NF, Sampath S, Atalar E (2001) Imaging longitudinal cardiac strain on short-axis images using strain-encoded MRI. Magn Reson Med 46:324–334PubMedCrossRefGoogle Scholar
  43. Paulus WJ, Tschope C, Sanderson JE et al (2007) How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J 28:2539–2550PubMedCrossRefGoogle Scholar
  44. Rathi VK, Doyle M, Yamrozik J et al (2008) Routine evaluation of left ventricular diastolic function by cardiovascular magnetic resonance: a practical approach. J Cardiovasc Magn Reson 10:36PubMedCrossRefGoogle Scholar
  45. Remme WJ, Swedberg K (2001) Guidelines for the diagnosis and treatment of chronic heart failure. Eur Heart J 22:1527–1560PubMedCrossRefGoogle Scholar
  46. Rosamond W, Flegal K, Furie K et al (2008) Heart disease and stroke statistics–2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 117(4):e25–e146PubMedCrossRefGoogle Scholar
  47. Sanders GD, Kong MH, Al-Khatib SM et al (2010) Cost-effectiveness of implantable cardioverter defibrillators in patients over 65 years of age. Am Heart J 160:122–131PubMedCrossRefGoogle Scholar
  48. Sasaki H, Sada M, Nishimura T et al (1987) The expanded scope of effectiveness of nuclear magnetic resonance imaging to determine cardiac allograft rejection. Transpl Proc 19:1062–1064Google Scholar
  49. Scott GE, Nath RL, Friedlich JA et al (1983) Usefulness of myocardial edema to assess heterotopic allograft rejection in dogs. Heart Transpl 2:232–237Google Scholar
  50. Singh JP, Houser S, Heist EK et al (2005) The coronary venous anatomy: A segmental approach to aid cardiac resynchronization therapy. J Am Coll Cardiol 46:68–74PubMedCrossRefGoogle Scholar
  51. Smart FW, Young JB, Weilbaecher D et al (1993) Magnetic resonance imaging for assessment of tissue rejection after heterotopic heart transplantation. J Heart Lung Transpl 12:403–410Google Scholar
  52. Sohn DW (2011) Heart failure due to abnormal filling of the heart. J Cardiol 57(2):148–159PubMedCrossRefGoogle Scholar
  53. Steen H, Merten C, Refle S et al (2008) HA. Prevalence of different gadolinium enhancement patterns in patients after heart transplantation. J Am. Coll Cardiol 52(14):1160–1167CrossRefGoogle Scholar
  54. Stewart S, Jenkins A, Buchan S et al (2002) The current cost of heart failure to the National Health Service in the UK. Eur J Heart Fail 4(3):361–371PubMedCrossRefGoogle Scholar
  55. Sung RK, Foster E (2011) Assessment of systolic dyssynchrony for cardiac resynchronization therapy is not clinically useful. Circulation 123(6):656–662PubMedCrossRefGoogle Scholar
  56. Taylor AJ, Cerqueira M, Hodgson JM et al (2010) ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 appropriate use criteria for cardiac computed tomography: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance. J Am Coll Cardiol 56(22):1864–1894PubMedCrossRefGoogle Scholar
  57. Vardas PE, Auricchio A, Blanc JJ et al (2007) Guidelines for cardiac pacing and cardiac resynchronization therapy: the task force for cardiac pacing and cardiac resynchronization therapy of the European society of cardiology. developed in collaboration with the European heart rhythm association. Eur Heart J 28:2256–2295PubMedCrossRefGoogle Scholar
  58. Walpoth BH, Lazeyras F, Tschopp A et al (1995) Assessment of cardiac rejection and immunosuppression by magnetic resonance imaging and spectroscopy. Transpl Proc 27:2088–2091Google Scholar
  59. White JA, Yee R, Yuan X et al (2006) Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony. J Am Coll Cardiol 48:1953–1960PubMedCrossRefGoogle Scholar
  60. Wilhelmi M, Pethig K, Wilhelmi M et al (2002) Heart transplantation: echocardiographic assessment of morphology and function after more than 10 years of follow-up. Ann Thorac Surg 74:1075–1079PubMedCrossRefGoogle Scholar
  61. Wilson RF, Christensen BV, Olivari MT, Simon A, White CW, Laxson DD (1991) Evidence for structural sympathetic reinnervation after orthotopic cardiac transplantation in humans. Circulation 83(4):1210–1220PubMedGoogle Scholar
  62. Younger JF, Plein S, Crean A et al (2009) Visualization of coronary venous anatomy by cardiovascular magnetic resonance. J Cardiovasc Magn Reson 11:26PubMedCrossRefGoogle Scholar
  63. Ypenburg C, Roes SD, Bleeker GB et al (2007) Effect of total scar burden on contrast-enhanced magnetic resonance imaging on response to cardiac resynchronization therapy. Am J Cardiol 99:657–660PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg  2011

Authors and Affiliations

  1. 1.Department of RadiologyUniversity Hospitals, Catholic University of LeuvenLeuvenBelgium

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