Dysphagia pp 107-131 | Cite as

Gastroesophageal Reflux Disease, Globus, and Dysphagia

Part of the Medical Radiology book series (MEDRAD)


Gastroesophageal reflux disease (GERD) is a highly prevalent disorder in Western society and closely linked with the production of two common symptoms—dysphagia and globus pharyngeus. The interrelationship of these symptoms with GERD and with each other is complex but critical to an understanding of patients' complaints, underlying pathological mechanisms and appropriate treatment planning. In this chapter we explore these relationships, related diagnostic methodology and options for treatment of reflux disorders, dysphagia and globus.


Proton Pump Inhibitor Vocal Fold Eosinophilic Esophagitis Botulinum Toxin Injection Reflux Episode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Allen J, Belafsky PC (2010) Endoscopic cricopharyngeal myotomy for Zenker diverticulum using the harmonic scalpel. Ear Nose Throat J 89:216–218PubMedGoogle Scholar
  2. Allen J, White CJ, Leonard RJ, Belafsky PC (2010) Effect of cricopharyngeal muscle surgery on the pharynx. Laryngoscope 120:1498–1503PubMedGoogle Scholar
  3. Allen J, Tinling SP, Johnston N, Belafsky P (2011) Effects of pepsin and alginate in an animal model of squamous cell carcinoma. Aliment Pharmacol Ther 33(Suppl 1):21–28Google Scholar
  4. Altman KW, Yu GP, Schaefer SD (2010) Consequence of dysphagia in the hospitalized patient. Impact on prognosis and hospital resources. Arch Otolaryngol Head Neck Surg 136:784–789PubMedGoogle Scholar
  5. Ames JA, Karnell LH, Gupta AK, Coleman TC, Karnell MP, Van Daele DJ, Funk GF (2011) Outcomes after the use of gastrostomy tubes in patients whose head and neck cancer was managed with radiation therapy. Head Neck 33(5):638–644. doi: 10.1002/hed.21506 Google Scholar
  6. Arevalo LF, Sharma N, Castell DO (2011) Symptomatic non-acid reflux—the new frontier in gastro-oesophageal reflux disease. Aliment Pharmacol Ther 33(Suppl 1):29–35Google Scholar
  7. Aviv JE, Mohr JP, Blizter A, Thomson JE, Close LG (1997) Restoration of laryngopharyngeal sensation by neural anastomosis. Arch Otolaryngol Head Neck Surg 123:154–160PubMedGoogle Scholar
  8. Aviv JE, Kaplan ST, Thomson JE, Spitzer J, Diamond B, Close LG (2000a) The safety of flexible endoscopic evaluation of swallowing with sensory testing (FEESST): an analysis of 500 consecutive evaluations. Dysphagia 15:39–44PubMedGoogle Scholar
  9. Aviv JE, Liu H, Parides M, Kaplan ST, Close LG (2000b) Laryngopharyngeal sensory deficits in patients with laryngopharyngeal reflux and dysphagia. Ann Otol Rhinol Laryngol 109:1000–1006PubMedGoogle Scholar
  10. Belafsky PC (2010) Manual control of the upper esophageal sphincter. Laryngoscope 120:S1–S16PubMedGoogle Scholar
  11. Belafsky PC, Rees CJ (2009) Functional oesophagoscopy: endoscopic evaluation of the oesophageal phase of deglutition. J Laryngol Otol 123:1031–1034PubMedGoogle Scholar
  12. Belafsky PC, Postma GN, Koufman JA (2002) Validity and reliability of the Reflux Symptom Index (RSI). J Voice 16:274–277PubMedGoogle Scholar
  13. Belafsky PC, Mouadeb DA, Rees CJ, Allen JE, Leonard RJ (2008) Validity and reliability of the Eating Assessment Tool (EAT-10). Ann Otol Rhinol Laryngol 117:919–924PubMedGoogle Scholar
  14. Borr C, Hielscher-Fastabend M, Lücking A (2007) Reliability and validity of cervical auscultation. Dysphagia 22:225–234PubMedGoogle Scholar
  15. Bours GJ, Speyer R, Lemmens J, Limburg M, de Wit R (2009) Bedside screening tests vs videofluoroscopy or fibreoptic endoscopic evaluation of swallowing to detect dysphagia in patients with neurological disorders: systematic review. J Adv Nurs 65:477–493PubMedGoogle Scholar
  16. Broniatowski M, Moore NZ, Grundfest-Broniatowski S, Tucker HM, Lancaster E, Krival K, Hadley AJ, Tyler DJ (2010) Paced glottic closure for controlling aspiration pneumonia in patients with neurologic deficits of various causes. Ann Otol Rhinol Laryngol 119:141–149PubMedGoogle Scholar
  17. Caro JJ, Salas M, Ward A (2001) Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine, and placebo: evidence from randomized clinical trials. Clin Ther 23:998–1017PubMedGoogle Scholar
  18. Carrau RL, Pou A, Eibling DE, Murry T, Ferguson BJ (1999) Laryngeal framework surgery for the management of aspiration. Head Neck 21:139–145PubMedGoogle Scholar
  19. Catania RA, Kavic SM, Roth JS, Lee TH, Meyer T, Fantry GT, Castellanos PF, Park A (2007) Laparoscopic Nissen fundoplication effectively relieves symptoms in patients with laryngopharyngeal reflux. J Gastrointest Surg 11:1579–1588PubMedGoogle Scholar
  20. Chassany O, Holtmann G, Malagelada J, Gebauer U, Doerfler H, Devault K (2008) Systematic review: health-related quality of life (HRQOL) questionnaires in gastro-oesophageal reflux disease. Aliment Pharmacol Ther 27:1053–1070PubMedGoogle Scholar
  21. Chen AY, Frankowski R, Bishop-Leone J, Hebert T, Leyk S, Lewin J, Geopfert H (2001) The development and validation of a dysphagia-specific quality-of-life questionnaire for patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 127:870–876PubMedGoogle Scholar
  22. Ciccaglione AF, Marzio L (2003) Effect of acute and chronic administration of the GABA B agonist baclofen on 24 hr pH metry and symptoms in controls subjects and in patients with gastroesophageal reflux disease. Gut 52:464–470PubMedGoogle Scholar
  23. Dean BB, Gano AD Jr, Knight K, Ofman JJ, Fass R (2004) Effectiveness of proton pump inhibitors in nonerosive reflux disease. Clin Gastroenterol Hepatol 2:656–664PubMedGoogle Scholar
  24. Del Negro A, Araújo MR, Tincani AJ, Meirelles L, Martins AS, Andreollo NA (2008) Experimental carcinogenesis on the oropharyngeal mucosa of rats with hydrochloric acid, sodium nitrate and pepsin. Acta Cir Bras 23(4):337–342PubMedGoogle Scholar
  25. Dent J, Vakil N, Jones R, Bytzer P, Schoning U, Halling K, Junghard O, Lind T (2010) Accuracy of the diagnosis of GORD by questionnaire, physicians and a trial of proton pump inhibitor treatment: the Diamond Study. Gut 59:7114–7721Google Scholar
  26. Dettmar PW, Sykes J, Little SL, Bryan J (2006) Rapid onset of effect of sodium alginate on gastro-oesophageal reflux compared with ranitidine and omeprazole, and relationship between symptoms and reflux episodes. Int J Clin Pract 60:275–283PubMedGoogle Scholar
  27. El-Serag HB, Hepworth EJ, Lee P, Sonnenberg A (2001) Gastroesophageal reflux disease is a risk factor for laryngeal and pharyngeal cancer. Am J Gastroenterol 96(7):2013–2018PubMedGoogle Scholar
  28. Farley A, Wruble LD, Humphries TJ (2000) Rabeprazole versus ranitidine for the treatment of erosive gastroesophageal reflux disease: a double-blind, randomized clinical trial. Rabeprazole Study Group. Am J Gastroenterol 95:1894–1899PubMedGoogle Scholar
  29. Farri A, Accornero A, Burdese C (2007) Social importance of dysphagia: its impact on diagnosis and therapy. Acta Otorhinolaryngol Ital 27:83–86PubMedGoogle Scholar
  30. Fox M (2011) Identifying the causes of reflux events and symptoms—new approaches. Aliment Pharmacol Ther 33(Suppl 1):36–42Google Scholar
  31. Francis DO, Maynard C, Weymuller EA, Reiber G, Merati AL, Yueh B (2011) Reevaluation of gastroesophageal reflux disease as a risk factor for laryngeal cancer. Laryngoscope 121:102–105PubMedGoogle Scholar
  32. Frye JW, Vaezi MF (2008) Extraesophageal GERD. Gastroenterol Clin North Am 37:845–858PubMedGoogle Scholar
  33. Fujimoto Y, Hasegawa Y, Yamada H, Ando A, Nakashima T (2007) Swallowing function following extensive resection of oral or oropharyngeal cancer with laryngeal suspension and cricopharyngeal myotomy. Laryngoscope 117:1343–1348PubMedGoogle Scholar
  34. Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, Bonis P, Hassall E, Straumann A, Rothenberg ME, (FIGERS) subcommittee (2007) Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 133:1342–1363PubMedGoogle Scholar
  35. Galli J, Cammarota G, Calò L, Agostino S, D’Ugo D, Cianci R, Almadori G (2002) The role of acid and alkaline reflux in laryngeal squamous cell carcinoma. Laryngoscope 112:1861–1865PubMedGoogle Scholar
  36. Gill G, Johnston N, Buda A, Pignatelli M, Pearson J, Dettmar P, Koufman J (2005) Laryngeal epithelial defenses against laryngopharyngeal reflux: investigation of E-cadherin, carbonic anhydrase isoenzyme III, and pepsin. Ann Otol Rhinol Laryngol 114:913–921PubMedGoogle Scholar
  37. Gisbert JP, Cooper A, Karagiannis D, Hatlebakk J, Agréus L, Jablonowski H, Zapardiel J (2009) Impact of gastroesophageal reflux disease on patients’ daily lives: a European observational study in the primary care setting. Health Qual Life Outcomes 7:60PubMedGoogle Scholar
  38. Gold BD (2004) Epidemiology and management of gastroesophageal reflux in children. Aliment Pharmacol Ther 19(Suppl 1):22–27PubMedGoogle Scholar
  39. He J, Ma X, Zhao Y, Wang R, Yan X, Yan H, Yin P, Kang X, Fang J, Hao Y, Dent J, Sung JJY, Wallander MA, Johansson S, Liu W, Li Z (2010) A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal disease in China. BMC Gastroenterol 10:94PubMedGoogle Scholar
  40. Hendricker RM, deSilva BW, Forrest LA (2010) Gore-Tex medialization laryngoplasty for treatment of dysphagia. Otolaryngol Head Neck Surg 142:536–539PubMedGoogle Scholar
  41. Herrmann IF (1992) Surgical solutions for aspiration problems. J Jpn Bronchoesophageal Soc 43:72–79Google Scholar
  42. Hurtado CW, Furuta GT, Kramer RE (2011) Etiology of esophageal food impaction in children. J Pediatr Gastroenterol Nutr 52:43–46PubMedGoogle Scholar
  43. Johnston N, Bulmer D, Gill G, Panetti M, Ross P, Pearson J, Pignatelli M, Axford S, Dettmar P, Koufman J (2003) Cell biology of laryngeal epithelial defenses in healthy and disease: further studies. Ann Otol Rhinol Laryngol 112:481–491PubMedGoogle Scholar
  44. Johnston N, Knight J, Dettmar P, Lively M, Koufman J (2004a) Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope 114:2129–2134PubMedGoogle Scholar
  45. Johnston N, Knight J, Dettmar PW, Lively MO, Koufman J (2004b) Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope 114(12):2129–2134PubMedGoogle Scholar
  46. Johnston N, Dettmar PW, Lively MO, Postma GN, Belafsky PC, Birchall M, Koufman JA (2006) Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease. Ann Otol Rhinol Laryngol 115(1):47–58PubMedGoogle Scholar
  47. Johnston N, Wells CW, Blumin JH, Toohill RJ, Merati AL (2007) Receptor-mediated uptake of pepsin by laryngeal epithelial cells. Ann Otol Rhinol Laryngol 116(12):934–938PubMedGoogle Scholar
  48. Jones R, Coyne K, Wiklund I (2007) The Gastro-oesophageal Reflux Disease Impact Scale: a patient management tool for primary care. Aliment Pharmacol Ther 25:1451–1459PubMedGoogle Scholar
  49. Kanakala V, Lamb CA, Haigh C, Stirling RW, Attwood SE (2010) The diagnosis of primary eosinophilic esophagitis in adults: missed or misinterpreted? Eur J Gastroenterol Hepatol 22:848–855PubMedGoogle Scholar
  50. Kinekawa F, Kubo F, Matsuda K, Kobayashi M, Furuta Y, Fujita Y, Okada H, Muraoka T, Yamanouchi H, Inoue H, Uchida Y, Masaki T (2008) Esophageal function worsens with long duration of diabetes. J Gastroenterol 43:338–344PubMedGoogle Scholar
  51. Knight J, Lively MO, Johnston N, Dettmar PW, Koufman JA (2005) Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux. Laryngoscope 115(8):1473–1478PubMedGoogle Scholar
  52. Koek GH, Sifrim D, Lerut T, Janssens J, Tack J (2003) Effect of the GABA(B) agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors. Gut 52:1397–1402PubMedGoogle Scholar
  53. Kos MP, David EF, Klinkenberg-Knol EC, Mahieu HF (2010) Long-term results of external upper esophageal sphincter myotomy for oropharyngeal dysphagia. Dysphagia 25:169–176PubMedGoogle Scholar
  54. Kotby MN, Hassan O, El-Makhzangy AMN, Farahat M, Shadi M, Milad P (2010) Gastroesophageal reflux/laryngopharyngeal reflux disease: a critical analysis of the literature. Eur Arch Otorhinolaryngol 267:171–179PubMedGoogle Scholar
  55. Koufman J (1991) The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): A clinical investigation of 225 patients using ambulatory 24-hr pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 101(Suppl 53):1–78PubMedGoogle Scholar
  56. Koufman JA (2002) Prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux. Laryngoscope 112:1606–1609PubMedGoogle Scholar
  57. Ku PK, Abdullah VF, Vlantis AC, Lee KY, van Hasselt AC, Tong MC (2009) ‘Steam-boat’ supraglottic laryngoplasty for treatment of chronic refractory aspiration: a modification of Biller’s technique. J Laryngol Otol 123:1360–1363PubMedGoogle Scholar
  58. Lacy B, Weiser K, Chertoff J, Fass R, Pandolfino JE, Richter JE, Rothstein RI, Spangler C, Vaezi MF (2010) The diagnosis of gastroesophageal reflux disease. Am J Med 123:583–592PubMedGoogle Scholar
  59. Lang IM, Medda BK, Shaker R (2001) Mechanisms of reflexes induced by esophageal distension. Am J Physiol Gastrointest Liver Physiol 281:G1246–G1263PubMedGoogle Scholar
  60. Langmore SE (2003) Evaluation of oropharyngeal dysphagia: which diagnostic tool is superior? Curr Opin Otolaryngol Head Neck Surg 11:485–489PubMedGoogle Scholar
  61. Langmore SE, Schatz K, Olson N (1991) Endoscopic and videofluoroscopic evaluations of swallowing and aspiration. Ann Otol Rhinol Laryngol 100:678–681PubMedGoogle Scholar
  62. Lawson G, Remacle M, Jamart J, Keghian J (2003) Endoscopic CO2 laser-assisted surgery for cricopharyngeal dysfunction. Eur Arch Otorhinolaryngol 260:475–480PubMedGoogle Scholar
  63. Leslie P, Drinnan MJ, Finn P, Ford GA, Wilson JA (2004) Reliability and validity of cervical auscultation: a controlled comparison using videofluoroscopy. Dysphagia 19:231–240PubMedGoogle Scholar
  64. Lewin J, Gillenwater A, Garrett J, Bishop-Leone J, Nguyen D, Callender D, Ayers G, Myers J (2003) Characterization of laryngopharyngeal reflux in patients with premalignant and early carcinomas of the larynx. Cancer 97:1010–1014PubMedGoogle Scholar
  65. Lien HC, Wang CC, Hsu JY, Sung FC, Cheng KF, Liang WM, Kuo HW, Lin PH, Chang CS (2010) Classical reflux symptoms, hiatal hernia and overweight independently predict pharyngeal acid exposure in patients with suspected reflux laryngitis. Aliment Pharmacol Ther. doi: 10.1111/j.1365-2036.2010.04502.x
  66. Lim KB, Lee HJ, Lim SS, Choi YI (2009) Neuromuscular electrical and thermal-tactile stimulation for dysphagia caused by stroke: a randomized controlled trial. J Rehabil Med 41:174–178PubMedGoogle Scholar
  67. Lin PH, Hsiao TY, Chang YC, Ting LL, Chen WS, Chen SC, Wang TG (2011) Effects of functional electrical stimulation on dysphagia caused by radiation therapy in patients with nasopharyngeal cancer. Support Care Cancer 19:91–99PubMedGoogle Scholar
  68. Lindstrom D, Wallace J, Loehrl T, Merati A, Toohill R (2002) Nissen fundoplication surgery for extraesophageal manifestation of gastroesophageal reflux (EER). Laryngoscope 112:1762–1765PubMedGoogle Scholar
  69. Little F, Koufman J, Kohut R, Marshall R (1985) Effect of gastric acid on the pathogenesis of subglottic stenosis. Ann Otol Rhinol Laryngol 94:516–519PubMedGoogle Scholar
  70. Louis E, Tack J, Vandenhoven G, Taeter C (2009) Evaluation of the GERD Impact Scale, an international, validated patient questionnaire, in daily practice. Results of the ALEGRIA study. Acta Gastroenterol Belg 72:3–8PubMedGoogle Scholar
  71. Lowell SY, Poletto CJ, Knorr-Chung BR, Reynolds RC, Simonyan K, Ludlow CL (2008) Sensory stimulation activates both motor and sensory components of the swallowing system. Neuroimage 42:285–295PubMedGoogle Scholar
  72. Ludlow CL (2010) Electrical neuromuscular stimulation in dysphagia: current status. Curr Opin Otolaryngol Head Neck Surg 18:159–164PubMedGoogle Scholar
  73. Luostarinen M (1993) Nissen fundoplication for reflux esophagitis Long-term clinical and endoscopic results of 109 of 127 consecutive patients. Ann Surg 217:329–337PubMedGoogle Scholar
  74. Mainie I, Tutuian R, Shay S, Vela M, Zhang X, Sifrim D, Castell DO (2006a) Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedence-pH monitoring. Gut 55:1398PubMedGoogle Scholar
  75. Mainie I, Tutuian R, Agrawal A, Adams D, Castell DO (2006b) Combined multichannel intraluminal impedence-pH monitoring to select patients with persistent gastro-oesophageal reflux for laparoscopic Nissen fundoplication. Br J Surg 93:1483PubMedGoogle Scholar
  76. Maronian N, Azadeh H, Waugh P, Hillel A (2001) Association of laryngopharyngeal reflux disease and subglottic stenosis. Ann Otol Rhinol Laryngol 110:606–612PubMedGoogle Scholar
  77. McCoul ED, Goldstein NA, Koliskor B, Weedon J, Jackson A, Goldsmith AJ (2011) A prospective study of the effect of gastroesophageal reflux disease treatment on children with otitis media. Arch Otolaryngol Head Neck Surg 137:35–41PubMedGoogle Scholar
  78. McGlashan JA, Johnstone LM, Sykes J, Strugala V, Dettmar PW (2009) The value of liquid alginate suspension (Gaviscon Advance) in the management of laryngopharyngeal reflux. Arch Otorhinolaryngol 266:243–251Google Scholar
  79. McHorney CA, Bricker DE, Kramer AE, Rosenbek JC, Robbins J, Chignell KA, Logemann JA, Clarke C (2000a) The SWAL-QOL outcomes tool for oropharyngeal dysphagia in adults: I. Conceptual foundation and item development. Dysphagia 15:115–121PubMedGoogle Scholar
  80. McHorney CA, Bricker DE, Robbins J, Kramer AE, Rosenbek JC, Chignell KA (2000b) The SWAL-QOL outcomes tool for oropharyngeal dysphagia in adults: II. Item reduction and preliminary scaling. Dysphagia 15:122–133PubMedGoogle Scholar
  81. McHorney CA, Robbins J, Lomax K, Rosenbek JC, Chignell KA, Kramer AE, Bricker DE (2002) The SWAL-QOL and SWAL-CARE outcomes tool for oropharyngeal dysphagia in adults: III. Documentation of reliability and validity. Dysphagia 17:97–114PubMedGoogle Scholar
  82. McHorney CA, Martin-Harris B, Robbins J, Rosenbek JC (2006) Clinical validity of the SWAL-QOL and SWAL-CARE outcomes tool with respect to bolus flow measure. Dysphagia 21:141–148PubMedGoogle Scholar
  83. Meneghelli UG, Boaventura S, Moraes-Filho JP, Leitão O, Ferrari AP, Almeida JR, Magalhães AF, Castro LP, Haddad MT, Tolentino M, Jorge JL, Silva E, Maguilnik I, Fischer R (2002) Efficacy and tolerability of pantoprazole versus ranitidine in the treatment of reflux esophagitis and the influence of Helicobacter pylori infection on healing rate. Dis Esophagus 15:50–56PubMedGoogle Scholar
  84. Meng NH, Wang TG, Lien IN (2000) Dysphagia in patients with brainstem stroke: incidence and outcome. Am J Phys Med Rehabil 79:170–175PubMedGoogle Scholar
  85. Merati A, Lim H, Ulualp S, Toohill R (2005) Meta-analysis of upper probe measurements in normal subjects and patients with laryngopharyngeal reflux. Ann Otol Rhinol Laryngol 114:177–182PubMedGoogle Scholar
  86. Meurmann Y (1957) Suspension of the larynx with fascial strips on the hyoid bone for removal of deglutition disorders after trauma [in German]. Arch Ohren Nasen Kehlkopfbeilkd 172:96–104Google Scholar
  87. Musser J, Kelchner L, Neils-Strunjas J, Montrose M (2011) A comparison of rating scales used in the diagnosis of extraesophageal reflux. J Voice 25(3):293–300Google Scholar
  88. Nguyen NP, Moltz CC, Frank C, Vos P, Smith HJ, Karlsson U, Dutta S, Midyett FA, Barloon J, Sallah S (2004) Dysphagia following chemoradiation for locally advanced head and neck cancer. Ann Oncol 15:383–388PubMedGoogle Scholar
  89. Nguyen NP, Frank C, Moltz CC, Vos P, Smith HJ, Bhamidipati PV, Karlsson U, Nguyen PD, Alfieri A, Nguyen LM, Lemanski C, Chan W, Rose S, Sallah S (2006) Aspiration rate following chemoradiation for head and neck cancer: an underreported occurrence. Radiother Oncol 80:302–306PubMedGoogle Scholar
  90. Nocon M, Labenz J, Jaspersen D, Leodolter A, Richter K, Vieth M, Lind T, Malfertheiner P, Willich SN (2008) Health-related quality of life in patients with gastro-oesophageal reflux disease under routine care: 5-year follow-up results of the ProGERD study. Aliment Pharmacol Ther 29:662–668Google Scholar
  91. Noordzij J, Khidr A, Evans B, Desper E, Mittal R, Reibel J, Levine P (2001) Evaluation of omeprazole in the treatment of reflux laryngitis: a prospective, placebo-controlled, randomized, double-blind study. Laryngoscope 111:2147–2151PubMedGoogle Scholar
  92. Numans ME, Lau J, de Wit NJ, Bonis PA (2004) Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease. Ann Intern Med 140:518–527PubMedGoogle Scholar
  93. Orlando RC (2011) Oesophageal tissue damage and protection. Aliment Pharmacol Ther 33(Suppl 1):8–12Google Scholar
  94. Ozgursoy OB, Salassa JR (2010) Manofluorographic and functional outcomes after endoscopic laser cricopharyngeal myotomy for cricopharyngeal bar. Otolaryngol Head Neck Surg 142:735–740PubMedGoogle Scholar
  95. Ozulgedik S, Yorulmaz I, Gokcan K (2006) Is laryngopharyngeal reflux an important risk factor in the development of laryngeal carcinoma? Eur Arch Otorhinolaryngol 263:339–343Google Scholar
  96. Park W, Hicks DM, Khandwala F, Richter JE, Abelson TI, Milstein C, Vaezi MF (2005) Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response. Laryngoscope 115:1230–1238PubMedGoogle Scholar
  97. Park S, Chun HJ, Keum B, Uhm CS, Baek SK, Jung KY, Lee SJ (2010) An electron microscopic study—correlation of gastroesophageal reflux disease and laryngopharyngeal reflux. Laryngoscope 120:1303–1308PubMedGoogle Scholar
  98. Pearson JP, Parikh S (2011) Nature and properties of gastro-oesophageal and extra-oesophageal refluxate. Aliment Pharmacol Ther 33(Suppl 1):2–7Google Scholar
  99. Peng S, Xiong LS, Xiao YL, Lin JK, Wang AJ, Zhang N, Hu PJ, Chen MH (2010) Prompt upper endoscopy is an appropriate initial management in uninvestigated Chinese patients with typical reflux symptoms. Am J Gastroenterol 105:1947–1952PubMedGoogle Scholar
  100. Peponi E, Glanzmann C, Willi B, Huber G, Studer G (2011) Dysphagia in head and neck cancer patients following intensity modulated radiotherapy (IMRT). Rad Oncol 6:1Google Scholar
  101. Pitman M, Weissbrod P (2009) Endoscopic CO2 laser cricopharyngeal myotomy. Laryngoscope 119:45–53PubMedGoogle Scholar
  102. Postma G (2000) Ambulatory pH monitoring methodology. Ann Otol Rhinol Laryngol 109:10–14Google Scholar
  103. Postma G, Johnson L, Koufman J (2002) Treatment of laryngopharyngeal reflux. Ear Nose Throat J 81(Suppl 2):24–26PubMedGoogle Scholar
  104. Postma G, Cohen J, Belafsky P, Halum S, Gupta S, Bach K, Koufman J (2005) Transnasal esophagoscopy: revisited (over 700 consecutive cases). Laryngoscope 115:321–323PubMedGoogle Scholar
  105. Prasad GH, Alexander JA, Schleck CD, Zinsmeister AR, Smyrk TC, Elias RM, Locke GR 3rd, Talley NJ (2009) Epidemiology of eosinophilic esophagitis over three decades in Olmstead County, Minnesota. Clin Gastroenterol Hepatol 7:1055–1061PubMedGoogle Scholar
  106. Qadeer MA, Swoger J, Milstein C, Hicks DM, Ponsky J, Richter JE, Abelson TI, Vaezi MF (2005) Correlation between symptoms and laryngeal signs in laryngopharyngeal reflux. Laryngoscope 115:1947–1952PubMedGoogle Scholar
  107. Qadeer MA, Phillips CO, Lopez AR, Steward DL, Noordzij JP, Wo JM, Suurna M, Havas T, Howden CW, Vaezi MF (2006) Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials. Am J Gastroenterol 101:2646–2654PubMedGoogle Scholar
  108. Ramsey DJC, Smithard DG, Kalra L (2003) Early assessments of dysphagia and aspiration risk in acute stroke patients. Stroke 34:1252–1257PubMedGoogle Scholar
  109. Rees C (2007) In-office transnasal esophagoscope-guided botulinum toxin injection of the lower esophageal sphincter. Curr Opin Otolaryngol Head Neck Surg 15:409–411PubMedGoogle Scholar
  110. Rees CJ, Belafsky PC (2008) Laryngopharyngeal reflux: current concepts in pathophysiology, diagnosis, and treatment. Int J Speech Lang Pathol 10:245–253PubMedGoogle Scholar
  111. Reimer C, Søndergaard B, Hilsted L, Bytzer P (2009) Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy. Gastroenterology 137:80–87PubMedGoogle Scholar
  112. Ricker J, McNear S, Cassidy T, Plott E, Arnold H, Kendall B, Franklin K (2011) Routine screening for eosinophilic esophagitis in patients presenting with dysphagia. Ther Adv Gastroenterol 4:27–35Google Scholar
  113. Robbins J, Langmore S, Hinds JA, Erlichman M (2002) Dysphagia research in the 21st century and beyond: proceedings from Dysphagia Experts Meeting, August 21, 2001. J Rehabil Res Dev 39:543–548PubMedGoogle Scholar
  114. Ronkainen J, Aro P, Storskrubb T, Lind T, Bolling-Sternevald E, Junghard O, Talley NJ, Agreus L (2006) Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population—the Kalixanda study. Aliment Pharmacol Ther 23:1725–1733PubMedGoogle Scholar
  115. Ryu JS, Kang JY, Park JY, Nam SY, Choi SH, Roh JL, Kim SY, Choi KH (2009) The effect of electrical stimulation therapy on dysphagia following treatment for head and neck cancer. Oral Oncol 45:665–668PubMedGoogle Scholar
  116. Samuels TL, Johnston N (2009) Pepsin as a causal agent of inflammation during nonacidic reflux. Otolaryngol Head Neck Surg 141(5):559–563PubMedGoogle Scholar
  117. Samuels TL, Handler E, Syring ML, Pajewski NM, Blumin JH, Kerschner JE, Johnston N (2008) Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. Ann Otol Rhinol Laryngol 117(9):688–695PubMedGoogle Scholar
  118. Schroeder PL, Richter JE (1994) Swallowing disorders in the elderly. Semin Gastrointest Dis 5:154–165PubMedGoogle Scholar
  119. Sealock RJ, Rendon G, El-Serag HB (2010) Systematic review: the epidemiology of eosinophilic esophagitis in adults. Aliment Pharm Ther 32:712–719Google Scholar
  120. Shaw MJ, Talley NJ, Beebe TJ, Rockwood T, Carlsson R, Adlis S, Fendrick M, Jones R, Dent J, Bytzer P (2001) Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease. Am J Gastroenterol 96:52–57PubMedGoogle Scholar
  121. Shaw M, Dent J, Beebe T, Junghard O, Wiklund I, Lind T, Johnsson F (2008) The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials. Health Qual Life Outcomes 6:31PubMedGoogle Scholar
  122. Shaw JM, Barnman PC, Callanan MD, Beckingham IJ, Metz DC (2010) Long-term outcome of laparoscopic Nissen and laparoscopic Toupet fundoplication for gastroesophageal reflux disease: a prospective, randomized trial. Surg Endosc 24:924–932PubMedGoogle Scholar
  123. Smith DF, Ott DJ, Gelfand DW, Chen MYM (1998) Lower esophageal mucosal ring: correlation of referred symptoms with radiologic findings using a marshmallow bolus. Am J Roentgenol 171:1361–1365Google Scholar
  124. Steward D, Wilson K, Kelly D, Patil M, Schwartzbauer H, Long D, Welge J (2004) Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo control trial. Otolaryngol Head Neck Surg 131:342–350PubMedGoogle Scholar
  125. Strugala V, Avis J, Jolliffe IG, Johnstone LM, Dettmar PW (2009) The role of an alginate suspension on pepsin and bile acids—key aggressors in the gastric refluxate Does this have implications for the treatment of gastro-oesophageal reflux disease? J Pharm Pharmacol 61:1021–1028PubMedGoogle Scholar
  126. Swoger J, Ponsky J, Hicks DM, Richter JE, Abelson TI, Milstein C, Qadeer MA, Vaezi MF (2006) Surgical fundoplication in laryngopharyngeal reflux unresponsive to aggressive acid suppression: a controlled study. Clin Gastroenterol Hepatol 4:433–441PubMedGoogle Scholar
  127. Szczesniak MM, William RBH, Brake HM, Maclean JC, Cole IE, Cook IJ (2010) Upregulation of the esophago-UES relaxation response: a possible pathophysiological mechanism in suspected reflux laryngitis. Neurogastroenterol Motil 22:381–389PubMedGoogle Scholar
  128. Tack J (2005) Role of pepsin and bile in gastro-oesophageal reflux disease. Ali Pharmacol Ther 22(Suppl 1):48–54Google Scholar
  129. Tang M, Dettmar P, Batchelor H (2005) Bioadhesive oesophageal bandages: protection against acid and pepsin injury. Int J Pharmaceutics 292:169–177Google Scholar
  130. Tasker A, Dettmar PW, Panetti M, Koufman JA, Birchall J, Pearson JP (2002) Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope 112:1930–1934PubMedGoogle Scholar
  131. Tauber S, Gross M, Issing WJ (2002) Association of laryngopharyngeal symptoms with gastroesophageal reflux disease. Laryngoscope 112:879–886PubMedGoogle Scholar
  132. Tutuian R (2011) Obesity and GERD: pathophysiology and effect of bariatric surgery. Curr Gastroenterol Rep. doi: 10.1007/s11894-011-0191-y
  133. Vaezi MF, Qadeer MA, Lopez R, Colabianchi N (2006) Laryngeal cancer and gastroesophageal reflux disease: a case-control study. Am J Med 119:768–776PubMedGoogle Scholar
  134. Vakil NB, Traxler B, Levine D (2004) Dysphagia in patients with erosive esophagitis: prevalence, severity, and response to proton pump inhibitor treatment. Clin Gastroenterol Hepatol 2(8):665–668PubMedGoogle Scholar
  135. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global consensus group (2006) The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 101:1900–1920PubMedGoogle Scholar
  136. Wada T, Sasaki M, Kataoka H, Ogasawara N, Kanematsu T, Tanida S, Nojiri S, Ando T, Okochi M, Joh T (2009) Gastroesophageal and laryngopharyngeal reflux symptoms correlate with histopathologic inflammation of the upper and lower esophagus. J Clin Gastroenterol 43:249–252PubMedGoogle Scholar
  137. Wang X, Pitchumoni CS, Chandrarana K, Shah N (2008) Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy. World J Gastroenterol 14:709–712PubMedGoogle Scholar
  138. Westcott C, Hopkins B, Bach K, Postma G, Belafsky P, Koufman J (2004) Fundoplication for laryngopharyngeal reflux disease. J Am Coll Surg 199:23–30PubMedGoogle Scholar
  139. Wight R, Paleri V, Arullendram P (2003) Current theories for the development of nonsmoking and nondrinking laryngeal carcinoma. Curr Opin Otolaryngol Head Neck Surg 11:73–77PubMedGoogle Scholar
  140. Wilson JA (2005) What is the evidence that gastro-oesophageal reflux is involved in the aetiology of laryngeal cancer? Curr Opin Otolaryngol Head Neck Surg 12:97–100Google Scholar
  141. Wirth D, Kern B, Guenin MO, Montal I, Peterli R, Ackermann C, von Flue M (2006) Outcome and quality of life after open surgery versus endoscopic stapler-assisted esophagodiverticulostomy for Zenker’s diverticulum. Dis Esophagus 19:294–298PubMedGoogle Scholar
  142. Woodson G (1997) Cricopharyngeal myotomy and arytenoid adduction in the management of combined laryngeal and pharyngeal paralysis. Otolaryngol Head Neck Surg 116:339–343PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of OtolaryngologyNorth Shore HospitalTakapunaNew Zealand
  2. 2.Center for Voice and SwallowingUniversity of California, DavisCAUSA

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