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Postoperative Radiotherapy for Non-Small Cell Carcinoma

  • Ellen Kim
  • Mitchell Machtay
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

The role of post-operative radiotherapy (PORT) in treatment of non-small cell lung cancer (NSCLC) is unclear. Currently, the available evidence suggests that PORT is indicated for stage II and III (node-positive) NSCLC, but not for stage I NSCLC. However, it is still disputed in which cases patterns of failure necessitate further treatment following surgery, and if it is warranted, the question becomes whether to do radiotherapy instead of or with (before, during, or after) chemotherapy. Study of PORT is further complicated by the improvement of radiotherapy techniques in recent decades, and the shortage of well-defined prospective randomized trials since their implementation. Advances in technology have allowed more precise administration of higher doses of radiation with lower exposure of healthy tissues, resulting in greater local control and lower treatment-related toxicities. Weighing the benefits and risks to determine the overall usefulness of PORT is difficult and will require future studies.

Keywords

Adjuvant Chemotherapy Locoregional Control Bronchial Stump Port Group IIIA NSCLC 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg  2011

Authors and Affiliations

  1. 1.Department of Radiation OncologyCase Western Reserve UniversityClevelandUSA
  2. 2.Case Western Reserve University School of MedicineClevelandUSA

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