Novel Targeted Agents and Radiopharmaceuticals in Lung Cancer

  • Martin J. Edelman
  • Nadia Ijaz
Part of the Medical Radiology book series (MEDRAD)


The use of chemotherapy in addition to radiation has unquestionably improved outcomes in both small cell and non-small cell lung cancer. However, as in advanced disease, a plateau in efficacy has been reached. Over the past several decades numerous receptors and pathways responsible for normal cellular growth, maintenance and development have been identified. Derangements of these pathways frequently result in cancer, perpetuate cancer or result in resistance to treatment with chemotherapy and/or radiation. New agents targeting these pathways are now becoming available. Many of these have the potential to potentiate existing agents and/or radiation. In addition, radiation can itself be targeted by coupling radioisotopes to a moiety that will bind with receptors that are aberrantly expressed in cancer.


Vascular Endothelial Growth Factor Epidermal Growth Factor Receptor Small Cell Lung Cancer Interstitial Lung Disease Epidermal Growth Factor Receptor Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg  2011

Authors and Affiliations

  1. 1.University of Maryland Greenebaum Cancer CenterBaltimoreUSA

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