Combined Radiotherapy and Chemotherapy: Theoretical Considerations and Biological Premises

  • Branislav Jeremic
  • Dusan Milanovic
  • Nenad Filipovic
Part of the Medical Radiology book series (MEDRAD)


Starting point for full realization of clinical achievements of combined radiation therapy and chemotherapy in lung cancer is nothing but full understanding of general theoretical consideration as well as basic radiobiological premises of combined radiation and chemotherapy. Both are nowadays considered as mandatory ingredients in any consideration of combined radiation therapy and chemotherapy in lung cancer, as well as cancers in other tumour sites. More than 30 years ago, four basic mechanisms through which radiation therapy and chemotherapy can interact were established including spatial cooperation, independent cell kill, protection of normal tissues and enhancement of tumor response, the latter frequently replaced by terms such as radiosensitization or radio enhancement. Clinical evidence supports importance of exploitable mechanisms, although protection of normal tissue has never been proven. Novel radiation therapy technologies, occasionally changing fractionation pattern and new drugs/compounds will set the stage and scene for further verification of basic principles of combined radiation therapy and chemotherapy in clinical research of lung cancer.


Induction Chemotherapy Radiation Therapy Oncology Group Consolidation Chemotherapy Combine Radiation Therapy Intrathoracic Tumour 


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Copyright information

© Springer-Verlag Berlin Heidelberg  2011

Authors and Affiliations

  • Branislav Jeremic
    • 1
  • Dusan Milanovic
    • 2
  • Nenad Filipovic
    • 3
  1. 1.Institute of Lung DiseasesSremska KamenicaSerbia
  2. 2.Department of Radiation OncologyUniversity of FreiburgFreiburgGermany
  3. 3.Bioengineering Research CentreKragujevacSerbia

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