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Translational Research in Lung Cancer

  • Deepinder Singh
  • Kevin Bylund
  • Yuhchyau Chen
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

Translational research has become an important initiative emphasized by the National Institute of Health (NIH) in recent years, with goals of bringing benchtop research to the bedside through clinical trials, and translating clinical trials to the recommended care in clinical practice. Much progress has been made in the translational research of lung cancer. Molecular predictive tumor markers, such as mutation of epidermal growth factor receptor (EGFR), markers of DNA repair (excision repair cross-complementing group 1 gene product [ERCC1]; regulator subunit of ribonucleotide reductase [RRM1]; human MutS homologue 2 [hMSH2], human MutL homologue 1 [hMLH1]), and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) have been identified to predict response to molecular targeting agents for non-small cell lung cancer (NSCLC). Serum proteomic profiling was found to predict response to EGFR tyrosine kinase inhibitor (TKI) treatment of NSCLC. Serum markers such as chromogranin A (CgA), neuron-specific enolase (NSE), and pro-gastric-releasing peptide (ProGRP) may aid diagnosis, detection of disease progression or recurrence, and monitoring therapy for small cell lung cancer (SCLC). We present two clinical trial designs that are based on preclinical investigations that offer the rationale and hypotheses for taxane-based chemoradiation treatment to maximize chest tumor control and to target distant micrometastasis for stage III NSCLC. While stage III NSCLC in general is associated with >50% chest failure and a median survival of 14–17 months after chemoradiation treatments, the outcome of this translational approach has yielded a 97% in-field tumor control in study U1597, and 32 months overall survival in study U1500.

Keywords

Epidermal Growth Factor Receptor Small Cell Lung Cancer Epidermal Growth Factor Receptor Mutation Epidermal Growth Factor Receptor Gene Small Cell Lung Cancer Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg  2011

Authors and Affiliations

  1. 1.University of Rochester Medical CenterRochesterUSA

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